研究目的
To survey and summarize approaches for improving targetability, response rate, and photostability in optical bioimaging for in vivo applications.
研究成果
The review highlights progress in enhancing targetability, response rate, and photostability for bioimaging, making fluorescent probes suitable for real-time visualization in vitro and in vivo. Future directions include developing more functional AIE materials, NIR-II fluorophores, and improving clinical translatability.
研究不足
The paper discusses limitations such as challenges in developing AIE-active materials, need for novel NIR fluorophores, and understanding internalization and excretion pathways of nanoprobes. It also notes issues like dye leakage in nano-encapsulation and difficulties in integrating target ligands for certain fluorophores.
