1：Experimental Design and Method Selection:

The study designed nanocomposites using upconversion nanoparticles (UCNPs) to convert NIR light to UV/Vis light, triggering drug release from a photo-responsive copolymer (PEG-NMAB-PLA). Methods included synthesis of the copolymer, preparation of nanocomposites via thin-film hydration, and characterization using various techniques.

2：Sample Selection and Data Sources:

Samples included synthesized copolymers, UCNPs (NaYF4:0.3%Tm@CaF2), drugs (doxorubicin, Nile red), and cell lines (MCF-7). Data were obtained from in vitro and in vivo experiments.

3：3%Tm@CaF2), drugs (doxorubicin, Nile red), and cell lines (MCF-7). Data were obtained from in vitro and in vivo experiments. List of Experimental Equipment and Materials:

3. List of Experimental Equipment and Materials: Equipment included Malvern Zetasizer for size measurement, JEM-1400 TEM for morphology, fluorescence spectrophotometer for optical properties, UV-vis spectroscopy, HPLC for drug release analysis, confocal microscopy for cell imaging, and CCK-8 assay for cytotoxicity. Materials included chemicals from Aladdin Reagent, Biomatrik Inc., Sigma-Aldrich, and GIBCO.

4：Experimental Procedures and Operational Workflow:

Procedures involved synthesis of NMAB-ester and PNP copolymer, preparation of drug-loaded micelles and nanocomposites, characterization, optical property measurements, photo-dissociation reactions, drug release studies, cell uptake assays, cytotoxicity tests, and in vivo antitumor efficacy studies in mice.

5：Data Analysis Methods:

Data were analyzed using statistical methods (e.g., IC50 calculation, tumor inhibition ratio), with software tools for spectroscopy and microscopy not specified.