1：Experimental Design and Method Selection:

The study involved synthesizing Fe3O4@Au, Fe3O4@Au@SiO2, and Fe3O4@Au@β-CD nanoparticles through covalent bonding and electrostatic interactions, with comparisons to evaluate water solubility, biocompatibility, imaging, and drug delivery capabilities. Theoretical models include aggregation-induced emission and pH-sensitive drug release.

2：Sample Selection and Data Sources:

Samples included synthesized nanoparticles, gastric cancer cells (MGC-803), and normal gastric epithelial cells (GES-1) from the Cell Bank of Type Culture Collection of Chinese Academy of Sciences. Data were acquired through various spectroscopic and imaging techniques.

3：List of Experimental Equipment and Materials:

Equipment includes Bruker Tensor 27 spectrometer, Hitachi U3900 spectrometer, Horiba FluoroMax-4 spectrofluorometer, TEM (JEM-2010F), Zetasizer Nano ZS90, NETZSCH TG 209 F3 Tarsus, confocal fluorescence microscope (LSM-880, Zeiss), LakeShore 7410, Smartracer relaxometer, micro plate reader (Scientific Multiskan MK3, thermo). Materials include HAuCl4·4H2O, L-cysteine, Fe(acac)3, DMAP, DCC, diphenyl ether, oleylamine, CTAB, n-hexane, DMSO, alcohol, fetal bovine serum, PBS, MTT, paraformaldehyde, formazan, β-CD, TEOS, DOX.

4：Experimental Procedures and Operational Workflow:

Synthesis steps involved preparing L-cys-AuNCs, Fe3O4-CTAB NPs, Fe3O4@Au NPs, Fe3O4@Au@SiO2 NPs, and Fe3O4@Au@β-CD NPs. Characterization included FT-IR, UV-Vis, PL spectra, TEM, DLS, TGA, M-H curves, relaxivity measurements. Biological assays included MTT for cytotoxicity, confocal imaging for cell uptake, and drug loading/release studies with DOX.

5：Data Analysis Methods:

Data were analyzed using statistical methods for cell viability, linear regression for relaxivity, and fluorescence/absorption spectroscopy for quantification. Software tools were not specified.