研究目的
Investigating the development of a non-invasive wearable device to measure vital signs, specifically systolic blood pressure, using Fiber Bragg Grating (FBG) sensors.
研究成果
The study confirmed the validity of using FBG sensors for non-invasive systolic blood pressure measurement by demonstrating a significant correlation between reference and estimated values, with standard errors within the target accuracy of ±5 mmHg. This supports the potential for developing a low-constraint, wearable vital sign sensor. Future work should focus on reducing body motion effects, exploring multivariate analysis from pulse wave features, and miniaturizing the system for practical applications.
研究不足
The study was conducted on a small sample of healthy young males, limiting generalizability to other populations like hypertensive patients, elderly, or children. Measurements were done in a quiet state without body movement, so the impact of motion on wearable applications is not addressed. Sensor fixation position errors could introduce measurement inaccuracies, and the use of a cuff-based reference method may not capture beat-to-beat blood pressure variations. The reliance on PTT alone for blood pressure estimation may lack reliability compared to multivariate approaches.
1:Experimental Design and Method Selection:
The study uses FBG sensors to measure pulse waves at two body points (wrist and elbow) and calculates systolic blood pressure based on Pulse Transit Time (PTT). The rationale is to leverage the high sensitivity and non-invasive nature of FBG sensors for continuous vital sign monitoring. Theoretical models include the relationship between PTT and systolic blood pressure, derived from principles like Moens-Korteweg equation.
2:Sample Selection and Data Sources:
Four healthy male subjects in their 20s (Subjects A, B, C, D) were selected. Their height, weight, and age averages and standard deviations are provided in Table 1. Data were acquired from pulse waves measured at the wrist and elbow.
3:Data were acquired from pulse waves measured at the wrist and elbow.
List of Experimental Equipment and Materials:
3. List of Experimental Equipment and Materials: Equipment includes a heterodyne FBG sensor system (PF25-S01 by Nagano Keiki Co.), electronic sphygmomanometer (HEM-1020 by OMRON Corp.), medical tape for sensor fixation, and a PC with LabVIEW software (by National Instruments Corp.) for data analysis. Materials involve FBG sensors with specific reflection wavelength ranges (e.g., 1530 ± 0.5 nm, 1550 ± 0.5 nm, 1560 ± 0.5 nm).
4:5 nm, 1550 ± 5 nm, 1560 ± 5 nm).
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Sensors were fixed perpendicular to the artery direction on the skin surface at the wrist and elbow using medical tape. Pulse waves were acquired simultaneously with blood pressure measurements using the electronic sphygmomanometer. Measurements were conducted in a supine position to ensure heart-level alignment. Data were sampled at 1 kHz after averaging 20 points from a 20 kHz sampling rate to reduce noise. A bandpass filter (0.5 < f < 5 Hz) was applied to the pulse waves for feature extraction and noise reduction. Peak detection was performed using quadratic polynomial approximation, and PTT was calculated as the average time difference between corresponding peaks from wrist and elbow waveforms over the measurement period.
5:5 < f < 5 Hz) was applied to the pulse waves for feature extraction and noise reduction. Peak detection was performed using quadratic polynomial approximation, and PTT was calculated as the average time difference between corresponding peaks from wrist and elbow waveforms over the measurement period.
Data Analysis Methods:
5. Data Analysis Methods: Data analysis involved calculating PTT from filtered pulse waves, constructing calibration curves for systolic blood pressure using leave-one-out cross-validation, and comparing estimated values with reference values from the electronic sphygmomanometer. Statistical analysis included correlation coefficients and standard errors, with a target accuracy of ±5 mmHg. LabVIEW software was used for these analyses.
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