研究目的
To develop and characterize piezo-biocomposites as load-bearing orthopedic implants by combining hydroxyapatite and barium titanate using conventional sintering.
研究成果
Conventionally sintered HA-BT piezo-biocomposites exhibit enhanced compressive strength, good bioactivity, and biocompatibility, making them viable candidates for load-bearing orthopedic implants. The cost-effective sintering method allows for complex shapes, but further studies are needed to optimize properties and validate in vivo performance.
研究不足
The conventional sintering process results in higher porosity and lower relative density compared to advanced methods like spark plasma sintering, which may affect mechanical properties. The reactive sintering leads to decomposition of phases, potentially impacting biocompatibility and performance. The study is preliminary and requires further in vivo testing to confirm efficacy.
1:Experimental Design and Method Selection:
The study uses conventional sintering to consolidate hydroxyapatite (HA) and barium titanate (BT) composites, chosen for its cost-effectiveness and industrial viability. The sintering process is reactive, leading to decomposition of BT into various compounds.
2:Sample Selection and Data Sources:
Samples are prepared with 0, 20, and 40 wt% BT in HA, using educational grade HA from Fisher Scientific, BT (
3:5%, particle size ≤ 2 μm) and polyvinyl alcohol (PVA) from Sigma-Aldrich. List of Experimental Equipment and Materials:
Equipment includes a conventional sintering furnace (Zircar Zirconia, Inc., Florida, NY), universal testing machine (model 5569, Instron, Norwood, MA, USA), Vickers microhardness tester, X-ray diffractometer (Ultima III; Rigaku, The Woodlands, TX), FTIR spectrometer (UMA-600 Microscope, Varian Excalibur Series, Digilab, Holliston, MA, USA), scanning electron microscope (S-4800, Hitachi, Japan), and materials include HA, BT, PVA, simulated body fluid (SBF) components, and cell culture reagents.
4:Experimental Procedures and Operational Workflow:
Powders are mixed manually, pressed into pellets, sintered at 1200°C for 1 hour, then characterized for physical, mechanical properties, phase composition, morphology, bioactivity in SBF, and in vitro cytocompatibility using MC3T3-E1 cells.
5:Data Analysis Methods:
Data are analyzed using standard equations for density, porosity, compressive strength, hardness, fracture toughness, XRD patterns with JADE software, FTIR spectra, SEM images with ImageJ software, and cell viability assays with MTT.
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