研究目的
To show the presence of an active neovascular membrane in age-related macular degeneration even if optical coherence tomography (OCT) does not detect intra- or sub-retinal edema.
研究成果
OCT can show a reduction in retinal edema but is not always able to detect the presence of active neovascular networks. Intravitreal anti-VEGF injections may improve vessel permeability without necessarily eliminating the neovascular network, leading to potential underestimation of disease activity if only OCT is used. Future use of angio-OCT could enhance monitoring and treatment decisions.
研究不足
The study is a retrospective case report with a small sample size of only 3 patients, which may limit generalizability. It relies on specific imaging techniques (OCT and FA), and the findings might not apply to all cases or other diagnostic methods. The use of angio-OCT is suggested for future studies to improve detection.
1：Experimental Design and Method Selection:
Retrospective case report design. Optical coherence tomography (OCT) and fluorangiography (FA) were used to assess neovascular membrane activity and edema.
2：Sample Selection and Data Sources:
Three patients diagnosed with wet age-related macular degeneration (ARMD) who received intravitreal anti-VEGF injections (ranibizumab). Data were collected during follow-up after injections.
3：List of Experimental Equipment and Materials:
Heidelberg Spectralis (Heidelberg retina angiography + OCT) for spectral-domain OCT imaging, with a scan field of 30° horizontally and 15° vertically, and 19–25 OCT horizontal sections. Fluorangiography equipment for FA examinations.
4：Experimental Procedures and Operational Workflow:
Patients received at least one intravitreal injection per month for at least 3 months, followed by OCT evaluation 1 month after the last injection. If no edema was detected by OCT but visual acuity decreased, FA was performed to check for active neovascular networks.
5：Data Analysis Methods:
Qualitative analysis of OCT and FA images to detect the presence or absence of edema and neovascular networks.
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