研究目的
To test the hypothesis that the openness of the major temporal arcade (MTA) changes in the presence of plus disease, by quantification via parabolic modeling and arcade angle measurement, to assist in the detection and treatment of progressive retinopathy of prematurity.
研究成果
The study demonstrates that the openness of the major temporal arcade decreases in the presence of plus disease, as quantified by parabolic modeling and arcade angle measures. The diagnostic performance (Az values around 0.70-0.73) is encouraging, and combining these measures with other features like vessel tortuosity could improve computer-aided diagnosis of plus disease and retinopathy of prematurity.
研究不足
The study used a semiautomated method requiring user input for parameter selection. The database had an imbalance in the number of plus and no-plus cases (19 vs. 91), and the sample size was limited. The parabolic modeling may not fully capture asymmetry in the arcades, and the radius for TAA measurement lacks physiological justification. Future work could include more cases, automate parameter setting, and use higher-order curve fitting.
1：Experimental Design and Method Selection:
Semiautomated digital image processing techniques using a graphical user interface (GUI) for parabolic modeling of the MTA and measurement of the temporal arcade angle (TAA) based on a previous method. Statistical analysis with P values and ROC curves to assess diagnostic performance.
2：Sample Selection and Data Sources:
Retinal fundus images from the TROPIC database, consisting of 110 images from 41 preterm infants (16 females, 25 males), with 19 cases diagnosed with plus disease and 91 with no plus disease. Images captured using the RetCam 130 camera.
3：List of Experimental Equipment and Materials:
RetCam 130 camera (wide-field 130°; Clarity Medical Systems), computer with Matlab software (MathWorks), and ROCKIT software for ROC analysis.
4：Experimental Procedures and Operational Workflow:
Images were processed using Gabor filters for vessel detection, followed by parabolic modeling via the generalized Hough transform (GHT). Users marked the optic nerve head (ONH) and other points via the GUI. TAA was measured using circles of radii 60 and 120 pixels. Statistical analysis performed using t-tests and ROC analysis.
5：Data Analysis Methods:
Statistical significance assessed with P values from t-tests, diagnostic performance evaluated using area under the ROC curve (Az) with ROCKIT software, and correlation analysis using Pearson correlation coefficients.
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