研究目的
To investigate the anterior ocular anatomic origin of high-order aberration (HOA) components during accommodation in young healthy adults.
研究成果
HOA components change sequentially during accommodation, with spherical aberration decreasing first and correlating with ciliary muscle contraction, while coma changes later and relates to lens curvature alterations. This provides insights into the physiological origins of wavefront aberrations and their role in optical quality during accommodation.
研究不足
Image clarity of ciliary muscle may be affected by OCT light attenuation; manual adjustments in software introduce variability; eye rotational shifts and pupil shifts during accommodation were not fully corrected, potentially distorting measurements.
1：Experimental Design and Method Selection:
A customized system combining ultra-long scan depth OCT, ciliary muscle OCT, and Shack-Hartmann wavefront sensor with a Badal system was built to simultaneously capture images of ocular wavefront aberrations and anterior ocular biometry under step-controlled accommodative stimuli (0 D, 2 D, 4 D). Custom software was used for image correction and analysis based on Snell's principle.
2：Sample Selection and Data Sources:
30 young healthy adults (12 males, 18 females, mean age 31.1 years) with normal ophthalmic examination and no systemic diseases were enrolled. Subjects with SE greater than -6.00 D or over 40 years old were excluded.
3：1 years) with normal ophthalmic examination and no systemic diseases were enrolled. Subjects with SE greater than -00 D or over 40 years old were excluded. List of Experimental Equipment and Materials:
3. List of Experimental Equipment and Materials: Customized slit-lamp platform with CMOS-OCT, CM-OCT, Shack-Hartmann wavefront sensor, Badal system, visual target (Snellen E on glazed paper), LED bulb, electronic shutter, microlens array, CCD camera, and custom software.
4：Experimental Procedures and Operational Workflow:
Subjects fixated on a target while accommodative stimuli were applied. The system simultaneously captured images under natural pupils. Measurements were repeated after a 5-minute break. Images were processed using custom software to correct distortions and measure parameters.
5：Data Analysis Methods:
Statistical analysis using one-way ANOVA and Pearson correlation to compare parameters across accommodative states and relationships between biometry and aberrations. Zernike polynomials were used for wavefront analysis.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容-
Optical Coherence Tomography
CMOS-OCT
Custom
Imaging the anterior segment from cornea to back of crystalline lens with ultra-long scan depth.
-
Optical Coherence Tomography
CM-OCT
Custom
Imaging the ciliary muscle.
-
Shack-Hartmann Wavefront Sensor
Custom
Measuring wavefront aberrations of the eye.
-
Electronic Shutter
JML Optical
Inserting synchronized signal into the real-time image-acquiring video.
-
CCD Camera
Uniq Vision
Capturing distorted wavefront aberration images.
-
Movable Lens
Thorlabs
Providing stepwise accommodative stimuli in the Badal system.
-
Microlens Array
10x10
Edmund Optics
Balancing distorted wavefront aberration of the eye.
-
Software
Custom
Correcting optical distortions, measuring biometric parameters, and analyzing wavefront aberrations.
-
登录查看剩余6件设备及参数对照表
查看全部
