研究目的
To assess the subfoveal choroidal thickness (SFCT) in patients with MacTel type 2 and compare it with healthy controls using swept source optical coherence tomography (SS-OCT).
研究成果
The choroid in MacTel type 2 patients was significantly thickened compared to age- and sex-matched controls. SFCT may vary as structural changes worsen over time, with thicker choroid in non-proliferative stages and potential thinning in proliferative stages. This supports the association of MacTel type 2 with pachychoroid disorders, but the exact pathophysiology remains uncertain. Future long-term studies with larger cohorts are needed to validate and understand choroidal changes.
研究不足
The study was limited by retrospective recruitment; axial length and refractive error were not assessed or compared between cases and controls. The distribution of disease stages was skewed towards non-proliferative cases, and the number of proliferative cases was small. Automatic registration may not provide exact foveal location in diseased eyes, though foveal depression was checked manually.
1：Experimental Design and Method Selection:
A retrospective case-control study was conducted at a tertiary eye care center. The study adhered to the tenets of Helsinki and institutional guidelines. Cases were patients with MacTel type 2 diagnosed based on characteristic fundus features and OCT findings, staged using the Gass and Blodi classification. Controls were healthy adults with no posterior segment pathology, age- and sex-matched.
2：Sample Selection and Data Sources:
Cases included 65 eyes of 33 patients with MacTel type 2 detected from April 2016 to March
3：Controls included 61 eyes of 33 healthy adults selected from the hospital database. Exclusion criteria included media opacity, uveitis, other retinal pathologies, history of retinal treatment, and systemic vascular disorders. List of Experimental Equipment and Materials:
20 SS-OCT (Triton, Topcon Inc.), color fundus photography, fundus fluorescein angiography (FFA), and Snellen corrected distance visual acuity (CDVA) assessment tools.
4：Experimental Procedures and Operational Workflow:
All patients underwent detailed clinical history, ocular examination, CDVA, color fundus photography, SS-OCT imaging (12 × 12-mm long radial line scans centered on the fovea), and FFA in selected cases. Choroidal thickness was measured manually in the subfoveal region using SS-OCT scans where the choroido-scleral junction was best visible. Retinal thickness was also measured manually.
5：Data Analysis Methods:
Statistical analysis was performed using SPSS 23.0 software. Continuous variables were compared using t-tests and Mann-Whitney tests, categorical variables with chi-square tests, and correlations with Pearson and Spearman tests. A p-value ≤ 0.05 was considered significant.
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