研究目的
To develop a self-reporting photocatalyst for online fluorescence monitoring of high throughput RAFT polymerization, addressing the lack of techniques for simultaneous monitoring of multiple polymerizations in an online manner.
研究成果
ZnTPP serves as an effective self-reporting photocatalyst for online monitoring of PET-RAFT polymerization, enabling high-throughput analysis with fluorescence plate readers. This method is robust, oxygen-tolerant, and applicable to various monomers and molecular weights, facilitating rapid polymer library production.
研究不足
The technique may have deviations at very high monomer conversions (>90%), and the fluorescence correlation slope varies with different monomers and equipment, potentially requiring calibration for each setup.
1：Experimental Design and Method Selection:
The study utilized ZnTPP as a photocatalyst for PET-RAFT polymerization, with fluorescence spectroscopy for online monitoring. Polymerizations were conducted under yellow LED light in low-volume microtiter plates.
2：Sample Selection and Data Sources:
Samples included N,N-dimethylacrylamide (DMA) and other monomers, with RAFT agents like BTPA. Data were acquired using fluorescence spectroscopy, FTNIR spectroscopy, NMR spectroscopy, and GPC analysis.
3：List of Experimental Equipment and Materials:
Equipment included fluorescence cuvettes, microplate readers, LED light sources, and spectrometers. Materials included ZnTPP, monomers, RAFT agents, and solvents like DMSO.
4：Experimental Procedures and Operational Workflow:
Polymerizations were performed in sealed quartz cuvettes or 384-well plates under controlled light irradiation. Fluorescence emission spectra were acquired at specific wavelengths, and monomer conversion was monitored over time.
5：Data Analysis Methods:
Data were analyzed using linear regression to correlate fluorescence emission ratios with monomer conversion, with statistical analysis for uncertainty and correlation coefficients.
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