研究目的
To compare the outcomes of laparoscopic cholecystectomy in patients with and without real-time indocyanine green (ICG) for intraoperative bile duct visualization, aiming to reduce the risk of bile duct injury.
研究成果
Laparoscopic cholecystectomy with real-time indocyanine green fluorescence cholangiography enables better visualization and identification of the biliary tree, potentially increasing safety, although no significant differences in outcomes were found in this study. Future larger studies are needed to confirm benefits.
研究不足
Selection bias due to retrospective design and inclusion of only procedures by a single experienced surgeon; small sample size; results may not generalize to less experienced surgeons or other institutions; departmental standards (e.g., three-port technique) could affect outcomes.
1：Experimental Design and Method Selection:
A retrospective analysis of prospectively collected data from patients undergoing laparoscopic cholecystectomy with and without ICG. The study compared outcomes such as duration of surgery, bile duct injury rate, conversion rate, complications, and length of stay.
2：Sample Selection and Data Sources:
Seventy patients (29 with ICG, 41 without ICG) managed by a single surgeon at a referral centre for minimally invasive surgery. Patients were selected based on undergoing laparoscopic cholecystectomy for benign gallbladder diseases, excluding those with simultaneous open surgery or other reasons.
3：List of Experimental Equipment and Materials:
Laparoscopic equipment for cholecystectomy, indocyanine green (ICG) for injection, and the PINPOINT endoscopic fluorescence imaging system (Novadaq, Canada) for fluorescence imaging.
4：Experimental Procedures and Operational Workflow:
For ICG group,
5：5 ml of ICG was administered intravenously one hour before surgery. Fluorescence imaging was performed using the PINPOINT system to visualize the biliary tree. Standard laparoscopic cholecystectomy was performed using a three-port technique. Data Analysis Methods:
Data were analyzed using SPSS version 25. Non-normally distributed continuous variables were described with medians and ranges, and statistical tests (chi-square or Mann-Whitney U test) were used with a significance level of p < 0.05.
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