研究目的
To introduce a new LED equipment for brain photobiomodulation and present preliminary results from regional cerebral oxygen saturation and thermal imaging to quantify the biological effects of this potential therapeutic method.
研究成果
The LED photobiomodulation helmet shows promising preliminary results with increased regional cerebral oxygen saturation and temperature during and after stimulation. However, further research is necessary to validate these findings, optimize therapeutic parameters, and assess safety and efficacy for clinical applications in neurological disorders.
研究不足
Preliminary nature of the study with only one volunteer; significant temperature increase noted, which requires further investigation; lack of detailed statistical analysis; need for more measurements to confirm findings and optimize stimulation parameters.
1：Experimental Design and Method Selection:
The study involved using a prototype LED helmet for transcranial photobiomodulation, with measurements taken before, during, and after stimulation to assess changes in regional cerebral oxygen saturation (rSO2) and temperature. Near-infrared spectroscopy and thermal imaging were employed as non-invasive methods.
2：Sample Selection and Data Sources:
A healthy volunteer was used for the pilot measurement, with sensors applied to the frontal area of the brain.
3：List of Experimental Equipment and Materials:
LED helmet (prototype from Suyzeko with 256 LEDs at 810 nm wavelength), INVOS 5100C Oximeter for rSO2 measurements, thermal imaging equipment (not specified), elastic band to minimize light influence.
4：Experimental Procedures and Operational Workflow:
After a 20-minute resting period, LED stimulation was applied for 15 minutes with all LEDs active (60 mW per LED, 24 mW/cm2, ~15 W total). Measurements of rSO2 and temperature were conducted before (20 min), during (15 min), and after (20 min) stimulation.
5：Data Analysis Methods:
Results were presented graphically (Figures 3 and 4), showing increases in rSO2 and temperature; statistical methods were not detailed.
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