研究目的
To propose a refined method for feasible scan timing for coronary CT angiography (CCTA) using a time-density curve of the ascending aorta (AAo).
研究成果
The arrival to peak protocol (AP-P) using the interval from contrast media arrival to peak time in the ascending aorta from test-bolus data optimizes scan timing for 320-row CCTA, achieving higher prevalence of optimal scan timing and improved homogeneity of coronary arterial enhancement compared to the conventional protocol. This method corrects for effects of cardiac output and reduces interpatient variability.
研究不足
The study did not assess the diagnostic ability of CCTA using the proposed technique. It was limited to patients scanned with single cardiac cycle or half-scan reconstruction from multicycle data, and did not include patients with multicycle reconstruction for scan lengths over 160 mm or higher heart rates. The injection durations for test bolus and full bolus were fixed at 4.0 s and 10.0 s, respectively, so further studies are needed for other injection durations.
1：Experimental Design and Method Selection:
A prospective study comparing two protocols for determining scan timing in CCTA using a 320-row CT scanner. The conventional protocol (COV-P) used a fixed
2：0 s delay after peak enhancement time in the ascending aorta based on Bae's theory. The arrival to peak protocol (AP-P) used variable delay times (0, 0, or 0 s) based on the interval from contrast media arrival to peak time in the ascending aorta. Sample Selection and Data Sources:
129 consecutive patients referred for assessment of known or suspected coronary artery disease, scanned with a 320-row CT. Exclusion criteria included helical scanning or wide-volume scans over 160 mm.
3：List of Experimental Equipment and Materials:
320-row CT scanner (Aquilion ONE ViSION Edition; Toshiba Medical Systems), power injector (Dual Shot GX 7; Nemoto-Kyorindo), contrast media (iopamidol-370; Iopamiron; Bayer HealthCare), 20-gauge cannula, saline.
4：Experimental Procedures and Operational Workflow:
All patients underwent test-bolus examination with prospectively ECG-triggered axial scanning of the ascending aorta. CCTA was performed with inspiratory breath-hold. Scan parameters included tube potential, tube current, rotation time, detector configuration, scan length, and reconstructed field of view as specified. CT numbers were measured in various anatomical regions to define optimal scan timing and evaluate coronary enhancement.
5：Data Analysis Methods:
Statistical analysis using chi-squared test for prevalence, one-way ANOVA with Tukey's test for AP-time comparisons, unpaired t-test for CT number and heterogeneity comparisons, performed with GraphPad Prism software.
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