摘要： We describe herein the comprehensive theoretical and experimental studies on the transistor mobility of organic semiconductors by correlating two-dimensional (2D) intermolecular interaction with thin film morphology and the electronic coupling structure. We developed a novel bis-lactam based small molecule, 1,5-dioctyl-3,7-di(thiophen-2-yl)-1,5-naphthyridine-2,6-dione (C8-NTDT) with 2D-type C-H···O=C intermolecular interaction along the in-plane directions of crystal packing structure, which is characteristically different from the 1D-type intermolecular interaction shown in the typical bis-lactam molecule of C8-DPPT. Experimentally and theoretically, C8-NTDT exhibited more favorable thin film morphology and electronic coupling structure for charge transport due to their unique 2D intermolecular interactions compared with C8-DPPT. In fact, C8-NTDT exhibited hole mobility of up to 1.29 cm2 V-1 s-1 and on/off ratio of 107 in vacuum processed device. Moreover, the high solubility with 2D electronic coupling structure of C8-NTDT enables versatile solution processing for device fabrication without performance degradation compared to the vacuum processed device. As an example, we could demonstrate hole mobility of up to 1.10 cm2 V-1 s-1 for the spin-coated devices, which is one of the best performance among the solution processed organic field effect transistors based on bis-lactam containing small molecules.