研究目的
To evaluate the feasibility of five-dimensional Long Bone (5D LB), a new technique that automatically archives, reconstructs images, and measures lengths of fetal long bones, to assess whether the direction of volume sweep influences fetal long bone measurements in three-dimensional (3D) ultrasound and 5D LB, and to compare measurements of fetal long bone lengths obtained with 5D LB and those obtained with conventional two-dimensional (2D) and manual 3D techniques.
研究成果
5D LB is reproducible and comparable with conventional 2D and 3D ultrasound techniques for fetal long bone measurement, showing no significant differences in measurements and high agreement. However, it requires enhancements to address measurement failures and errors for broader clinical application.
研究不足
The study had a sample size of 39 pregnancies, which may limit generalizability. Measurement errors and failures occurred with 5D LB, particularly for tibia and fibula, due to factors like fetal movement, maternal obesity, and acoustic shadowing. The technique is not fully automated and requires further algorithm improvements to reduce dependency on operator expertise.
1：Experimental Design and Method Selection:
A prospective study design was used to compare 2D ultrasound, manual 3D ultrasound, and 5D LB techniques for measuring fetal long bone lengths. Statistical methods included paired t-test, interclass correlation coefficient, Bland-Altman plot, and Passing-Bablok regression for analysis of variability and agreement.
2：Sample Selection and Data Sources:
39 singleton pregnancies at 26+0 to 32+0 weeks of gestation were included. Exclusions were multiple pregnancies, fetuses with congenital anomalies, and mothers with medical diseases. Data were collected from the Department of Obstetrics at Yonsei University Health System.
3：List of Experimental Equipment and Materials:
Accuvix V20 Prestige ultrasound machine (Medison Co.), 2-6 MHz transabdominal transducer for 2D ultrasound, 4-8 MHz volume transducer for 3D ultrasound, and 5D LB software for automated measurements.
4：Experimental Procedures and Operational Workflow:
Two operators (one expert and one non-expert) performed 2D and 3D ultrasound examinations. For 3D ultrasound, volume data were acquired at different sweeping angles (long-90 and long-45) and manually reconstructed. For 5D LB, volume data were processed automatically by the system to reconstruct images and measure lengths. Measurements were taken for femur, tibia, and fibula of the right lower limb.
5：Data Analysis Methods:
Data were analyzed using PASW ver. 18.0 (SPSS Inc.) and MedCalc ver. 12.7 (MedCalc Software) for statistical tests including normality test, paired t-test, ICC, Bland-Altman plot, and Passing-Bablok regression.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
