研究目的
Development of a fast, simple, sensitive, and economic method for detection of naproxen in drug formulations, biological and environmental samples for toxicological and pharmaceutical purposes.
研究成果
The fabricated AgNPs@GO-β-CD/G-DVD electrode is a reproducible, versatile, stable, and low-cost sensor for voltammetric determination of naproxen. It exhibits good analytical characteristics such as a large dynamic range, high sensitivity, and selectivity, and is successfully applicable to real samples including pharmaceuticals and human urine.
研究不足
The study did not evaluate low pH values due to insolubility of naproxen in acidic solutions. The electrode stability was tested for up to one month, but long-term stability beyond that is not reported. Potential interferences from other compounds were tested, but not all possible interferents in complex matrices may have been considered.
1：Experimental Design and Method Selection:
The study involved designing a disposable electrode using a gold digital versatile disc (G-DVD) modified with a composite of graphene oxide decorated with silver nanoparticles and β-cyclodextrin (AgNPs@GO-β-CD). Cyclic voltammetry and differential pulse voltammetry were used to evaluate the electrochemical response to naproxen.
2：Sample Selection and Data Sources:
Naproxen was purchased from Pars Darou Co., and real samples included pharmaceutical tablets and human urine.
3：List of Experimental Equipment and Materials:
Equipment included a μ-Autolab type III potentiostat, FT-IR spectrometer, TEM, SEM with EDS, ultrasonic bath. Materials included graphite, AgNO3, NaBH4, β-CD, phosphate buffer, Nafion solution, and EMTEC DVD-RW discs.
4：Experimental Procedures and Operational Workflow:
Synthesis of GO and AgNPs@GO, construction of G-DVD electrode by peeling gold film from DVD and modifying with AgNPs@GO-β-CD suspension, electrochemical measurements in a three-electrode cell with optimized pH and accumulation time.
5：Data Analysis Methods:
Data were analyzed using NOVA 1.9 software, with calibration curves, limits of detection, and statistical analysis of reproducibility and interference.
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