1：Experimental Design and Method Selection:

The study designed a biomimetic MOF nanoparticle (aMMTm) combining PDT with antiangiogenesis therapy. It involved synthesizing porphyrinic Zr-MOF (PCN-224) nanoparticles, loading them with apatinib, coating with MnO2, and decorating with 4T1 tumor cell membrane. Methods included solvothermal synthesis, drug loading, coating processes, and in vitro and in vivo evaluations.

2：Sample Selection and Data Sources:

Samples included 4T1 mouse breast cancer cells, HUVEC human endothelial cells, Pan02 mouse pancreatic cancer cells, RAW 264.7 macrophages, and BALB/c mice with implanted 4T1 tumors. Data were sourced from cell culture, animal models, and various analytical techniques.

3：7 macrophages, and BALB/c mice with implanted 4T1 tumors. Data were sourced from cell culture, animal models, and various analytical techniques. List of Experimental Equipment and Materials:

3. List of Experimental Equipment and Materials: Equipment included transmission electron microscope (JEM200CX), Zetasizer Nano-ZS Particle Sizer and Zeta Potential Analyzer, LSM 710 confocal laser scanning microscope, Accuri C6 flow cytometer, Maestro in vivo fluorescent imaging system, BioSpec70/20USR 7.0 T MRI scanner, and others. Materials included zirconyl chloride octahydrate, H2TCPP, benzoic acid, DMF, KMnO4, PAH, apatinib, cell culture media, and various kits for assays.

4：0 T MRI scanner, and others. Materials included zirconyl chloride octahydrate, H2TCPP, benzoic acid, DMF, KMnO4, PAH, apatinib, cell culture media, and various kits for assays. Experimental Procedures and Operational Workflow:

4. Experimental Procedures and Operational Workflow: Procedures involved synthesis of MOF nanoparticles, drug loading, MnO2 coating, membrane decoration, characterization (TEM, DLS, EDS, SDS-PAGE), in vitro assays (cytotoxicity, cellular binding, GSH depletion, drug release), in vivo studies (pharmacokinetics, biodistribution, MRI, therapeutic efficacy), and histological analyses.

5：Data Analysis Methods:

Data were analyzed using statistical methods (Student's t-test, ANOVA) with SPSS17.0 software, flow cytometry, confocal microscopy, fluorescence imaging, MRI, and various staining techniques (H&E, TUNEL, immunohistochemistry).