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Assessment of 4-aminoantipyrine degradation and mineralization by photoelectro-Fenton with a BDD anode: Optimization, treatment in municipal secondary effluent, and toxicity
摘要： 4-Aminoantipyrine (4-AA), a persistent metabolite of dipyrone found in natural water, has been treated in 100 mL of aqueous 0.050 M Na2SO4 solutions at pH 3.0 by photoelectro-Fenton (PEF) with a 4 W UVA light. The assays were performed in a cell equipped with a BDD anode and an air-diffusion cathode for H2O2 generation. The formation of an unstable Fe(III)-4-AA complex with 1:2 molar ratio was evidenced. A 24 central composite design was used to assess the effect of four independent variables on PEF performance. The optimized conditions for 62.5 mg L-1 4-AA were: current density of 77.5 mA cm-2 and 47.75 mg L-1 Fe2+, yielding 99% 4-AA degradation at 7 min, and 45% 4-AA mineralization with 3.2% mineralization current efficiency at 130 min. Slightly slower degradation and similar mineralization were obtained under these conditions when 4-AA was spiked into a municipal secondary effluent, showing a low influence of natural organic matter on PEF. The initially high acute toxicity determined using Artemia salina was largely diminished upon PEF treatment.
关键词： 4-Aminoantipyrine,Response surface methodology,Photoelectro-Fenton,Municipal secondary effluent,Acute toxicity
更新于2025-09-23 15:23:52
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Protein Corona Formation of Human Serum Albumin with Carbon Quantum Dots from Roasted Salmon
摘要： As the food-borne nanoparticles enter the biological system, they will contact with various proteins to form protein coronas, which can affect their physicochemical properties and biological identity. In this study, the protein corona formation of carbon quantum dots (CQDs) from roast salmon with human serum albumin (HSA), as well as biological identity involving cell apoptosis, energy, glucose and lipid metabolism and acute toxicity in mice, were investigated. The HSA-CQD coronas formed between HSA and CQDs via static binding mechanism, and the binding site of CQDs on HSA located both in Sudlow’s site I and site II. The HSA-CQD coronas entered the cytoplasm and present in lysosomes or autolysosomes. Importantly, the HSA coronas mitigated the cytotoxicity of CQDs from 18.65% to 9.26%, and the energy metabolism was rectified from glycolytic to aerobic metabolism. The glucose and lipid metabolite profile of the HSA-CQD coronas differed from that of the CQDs, indicating that HSA-CQD coronas rectified disturbance in metabolism. Histopathological and blood biochemical analysis revealed no statistically significant difference between the testing and control mice after a single CQDs dose of 2000 mg/kg body weight. Overall, the results confirmed the formation of protein corona between HSA and food-borne fluorescent CQDs, and could be helpful for evaluating the safety of fluorescent CQDs from roast food items.
关键词： cytotoxicity,acute toxicity,protein coronas,human serum albumin,carbon quantum dots,metabolism,food-borne nanoparticles
更新于2025-09-23 15:21:01
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Comparison of acetaminophen degradation in UV-LED-based advance oxidation processes: Reaction kinetics, radicals contribution, degradation pathways and acute toxicity assessment
摘要： Ultraviolet light emitting diode (UV-LED)-based advanced oxidation processes (AOPs) including UV-LED/chloramine (UV-LED/NH2Cl), UV-LED/hydrogen peroxide (UV-LED/H2O2) and UV-LED/persulfate (UV-LED/PS), were adopted for acetaminophen (AAP) removal. Results showed that AAP could be effectively degraded by the hybrid processes compared to solely using with UV irradiation and oxidants. The AAP degradation in the three UV-LED-based AOPs were in the order of UV-LED/PS N UV-LED/H2O2 N UV-LED/NH2Cl and followed a pseudo-?rst-order kinetics. The degradation rate constant (kobs) increased with increasing oxidant dosage, whereas overdosing lowered the AAP degradation. The second-order rate constants of HO?, SO4??, and Cl? with AAP were calculated as 5.15 × 109, 7.66 × 109 and 1.08 × 1010 M?1 s?1, respectively. Under neutral conditions, the contributions of UV-LED, HO?, and Cl? to AAP degradation were 4.21%, 60.15% and 35.64% in the UV-LED/NH2Cl system, whereas the respective contributions of UV-LED, HO? and SO4?? to AAP degradation were 2.09%, 22.84% and 75.07% in UV-LED/PS system, respectively. Meanwhile, the corresponding contributions of the involved reactive species were found to be pH-dependence. The natural organic materials (NOM) inhibited the ? had different effects on AAP degradation in the ?, and NO3 AAP degradation, and the presence of Cl?, HCO3 three hybrid processes. The AAP degradation was signi?cantly inhibited in the three UV-LED-based AOPs in real water. In addition, the intermediate products were also identi?ed, and possible degradation pathways were proposed in the three UV-LED-based AOPs. The acute toxicity bioassay using bacterium Vibrio ?scheri suggested that the UV-LED/PS process was more effective than the UV-LED/H2O2 and UV-LED/NH2Cl processes in reducing the acute toxicity of the reacted AAP solution. Among the three UV-LED-based AOPs, the UV-LED/PS was found to be the most ef?cient process for AAP degradation.
关键词： Acute toxicity,Rate constants,UV-LED-based AOPs,Degradation pathways,Acetaminophen
更新于2025-09-23 15:21:01
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Enhanced solar- photocatalytic activity for the simultaneous degradation and detoxification of multiple chlorophenols by embedding plasmonic Pt into TiO2/H3PW12O40 nanopore
摘要： A novel Pt-TiO2/H3PW12O40 film was fabricated, which showed a considerable nonselective degradation and detoxification efficiency towards multiple chlorophenols (CPs), owing to the enhanced yield and separation efficiency of photogenerated electrons and holes. Based on the Mott-Schottky analysis, the carrier density of as-prepared Pt-TiO2/H3PW12O40 film reached 9.72 × 1022 cm?1, which was higher than that of Pt-TiO2, TiO2/H3PW12O40, and TiO2. The outstanding properties were attributed to the SPR effect and the formation of electrons traps from Pt0 (which was well protected by the nanopores that were formed by Ti-O-W and Ti-O-P); and H3PW12O40 that can efficiently transport electrons via its self-generated redox cycle. Meanwhile, the Pt-TiO2/H3PW12O40 film considerably lowers ecological risks of multiple CPs because O2?, as the primary radicals, can largely avoid the generation of products with a quinoid structure. The degradation pathways of multiple CPs were similar to those of single CP because the same hydroxyl substitution intermediate products were detected during the degradation, all of which followed the first-order reaction kinetics. Moreover, the excellent recycling performance of the Pt-TiO2/H3PW12O40 film guaranteed the reduction in economic cost and risks of secondary pollution. Therefore, the Pt-TiO2/H3PW12O40 film showed a considerable application potential in the removal of organic contaminants in aqueous environments.
关键词： Acute toxicity,Schottky junction,SPR effect,Multiple CPs,Degradation pathway
更新于2025-09-23 15:19:57