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Determination of BCM-7 based on an ultrasensitive aptasensor fabricated of gold nanoparticles and ZnS quantum dots
摘要： In this study, an ultrasensitive electrochemical aptasensor for the determination of the β-casomorphin 7 (BCM-7) as a promising biomarker of autism disorder is introduced. According to the proposed strategy, a glassy carbon electrode (GCE) was modi?ed by thiourea capped-ZnS QDs (ZnS-QDs) and gold nanoparticles (AuNPs) to further immobilization the amino-aptamer (NH2-Apt) on its surface. The NH2-Apt as a receptor of the BCM-7 was attached to the embedded surface via a formation of the Au–N bonds between the AuNPs and amino groups of the Apt. The evaluation of aptasensor by various electrochemical techniques exhibited successful sensing of the BCM-7 under two broad linear concentration ranges from 1 fM to 0.6 μM with a limit of detection (LOD) down to 350 aM. Also, the performance of the aptasensor in BCM-7 detection in real human urine samples was satisfactorily investigated. These ?ndings may facilitate distinguish of this challenging disorder and help human health.
关键词： Thiourea capped-ZnS QDs,β-casomorphin 7,Glassy carbon electrode,Gold nanoparticles,Aptasensor,Autism
更新于2025-09-23 15:21:01
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Hypoactivation of the Right Prefrontal Cortex Underlying Motor-Related Inhibitory Deficits in Children with Autism Spectrum Disorder: A Functional Near-Infrared Spectroscopy Study
摘要： Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are believed to share the symptom of neurocognitive dysfunction in executive functions. Regarding the components of executive functions, however, dysfunction of motor-response inhibitory control in children with ASD remains unclear. Thus, using functional near-infrared spectroscopy (fNIRS), we investigated whether putative inhibitory brain dysfunctions are applicable to children with ASD by adopting a go/no-go task, which has robustly evoked activation in typically developing (TD) children but not in ADHD children. Twenty-four ASD and 24 TD children underwent a go/no-go task, and their cortical hemodynamics were assessed using fNIRS. Relative to TD participants, ASD participants showed reduced activation in the right inferior frontal gyrus and middle frontal gyrus (IFG/MFG) during go/no-go tasks. The current finding suggests that hypoactivation in the right IFG/MFG during a go/no-go task would serve as a potential biomarker for identifying children with ASD.
关键词： autism spectrum disorder,attention-deficit hyperactivity disorder,optical topography,prefrontal cortex,executive dysfunction
更新于2025-09-10 09:29:36