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Bi-functional heater-thermometer Nd3+-doped nanoparticles with multiple temperature sensing parameters
摘要： Achieving a combination of real-time diagnosis and therapy in a single platform with sensitive thermometry and efficient heat production is a crucial step towards controllable photo-thermal therapy. Here, Nd3+-doped Y2O3 nanoparticles prepared by combined Pechini-foaming technique operating in first and second biological windows were demonstrated as thermal sensors within wide temperature range of 123–873 K and heaters with temperature increase by 100 K. Thermal sensing was performed based on various approaches: luminescence intensity ratio (electronic levels; Stark sublevels), spectral line position and line bandwidth were used as temperature dependent parameters. Applicability of regarded sensing parameters along with relative thermal sensitivity and temperature resolution were discussed and compared. Influence of Nd3+ doping concentration on thermometer and heater efficiency was also investigated.
关键词： Nanosensor,Biological window,Hyperthermia,Luminescence,Thermometry,Nd3+
更新于2025-09-23 15:23:52
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Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)
摘要： The paper presents an overview and concept of the European Union Horizon 2020 project “AMPLITUDE - Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy”. The project aims at the development of a novel label-free, multi-modal imaging tool for urothelial cancer diagnosis and therapy monitoring based on ultrafast fiber laser operating in the 3rd biological window with frequency doubling and additional 785 nm CW laser for Raman spectroscopy. The tool corresponds to clinical needs for better diagnosis of the pathohistological staging of tumours and in-vivo endoscopic assessment of depth of lesion invasiveness.
关键词： 3rd biological window,multiphoton imaging,bladder cancer,confocal microscopy,short-pulsed laser
更新于2025-09-19 17:13:59
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Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer
摘要： Luminescence nanothermometry has attracted much attention as a non-contact thermal sensing technique. However, it is not widely explored for in vivo applications owing to the low transparency of tissues for the light to be used. In this study, we performed biological temperature sensing in deep tissues using β-NaYF4 nanoparticles co-doped with Yb3+, Ho3+, and Er3+ (NaYF4: Yb3+, Ho3+, Er3+ NPs), which displayed two emission peaks at 1150 nm (Ho3+) and 1550 nm (Er3+) in the >1000 nm near-infrared wavelength region, where the scattering and absorption of light by biological tissues are at the minimum. The change in the luminescence intensity ratio of the emission peaks of Ho3+ and Er3+ (IHo/IEr) in the NaYF4: Yb3+, Ho3+, Er3+ nanothermometer differs corresponding to the thickness of the tissue. Therefore, the relationship between IHo/IEr ratio and temperature needs to be calibrated by the depth of the nanothermometer. The temperature-dependent change in the IHo/IEr was evident at the peritoneal cavity level, which is deeper than the subcutaneous tissue level. The designed experimental system for temperature imaging will open the window to novel luminescent nanothermometers for in vivo deep tissue temperature sensing.
关键词： near-infrared,Luminescence nanothermometry,biological window,NaYF4 nanoparticles,deep tissue temperature sensing
更新于2025-09-10 09:29:36