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Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects
摘要： Bismuth (Bi)-based nanomaterials (NMs) are widely used for computed tomography (CT) imaging guided photothermal therapy, however, the photodynamic property is hardly exhibited by these NMs due to the fast electron–hole recombination within their narrow bandgap. Herein, a sophisticated nanosystem is designed to endow bismuth sulfide (Bi2S3) nanorods (NRs) with potent photodynamic property. Zinc protoporphyrin IX (ZP) is linked to Bi2S3 NRs through a thermoresponsive polymer to form BPZP nanosystems. The stretching ZP could prebind to the active site of heme oxygenase-1 overexpressed in cancer cells, suppressing the cellular antioxidant defense capability. Upon NIR laser irradiation, the heat released from Bi2S3 NRs could retract the polymer and drive ZP to the proximity of Bi2S3 NRs, facilitating an efficient electron–hole separation in ZP and Bi2S3 NRs, and leading to reactive oxygen species generation. In vitro and in vivo studies demonstrate the promising photodynamic property of BPZP, together with their photothermal and CT imaging performance.
关键词： photodynamic therapy,heme oxygenase-1,bismuth sulfide,near-infrared,zinc protoporphyrin IX
更新于2025-09-23 15:23:52
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Green Synthesis of Bismuth Sulfide Nanostructures with Tunable Morphologies and Robust Photoelectrochemical Performance
摘要： Manipulating the morphology of chalcogenide semiconductor crystals to tailor their shape- and size-dependent properties is much desired but remains a grand challenge. Herein, we for the first time develop a green, facile and surfactant-free hydrothermal approach for the synthesis of bismuth sulfide (Bi2S3) with highly tunable morphologies in H2WO4 aqueous solution. The H2WO4 is prone to balance the concentration of Bi3+ to S2- in aqueous solution, thus modulating the nucleation and epitaxial growth of Bi2S3. Specifically, in the presence of lower H2WO4 concentration, low number of Bi2S3 nuclei facilitates the preferred growth of nanorod structures along [001] direction, while the Bi-deficient, S-rich conditions in higher H2WO4 concentration give rise to Bi2S3 nanotubes, presumably due to the stronger interlayer interaction and preferred growth in [hk0] direction. The resulting Bi2S3 nanostructures exhibit broad absorption overlapping UV-Visible-NIR regions and red-shifted absorption edges owing to the increased S/Bi molar ratio in Bi2S3 lattices. The Bi2S3 nanorods with higher aspect ratio demonstrate an enhanced photocurrent response by virtue of the improved charge carrier mobility along [001] direction. Different from previous synthetic methodologies, this work details a facile, effective, and environmentally-benign protocol for the synthesis of Bi2S3 nanomaterials in the aqueous medium without any organic reagents. Noteworthy, the excellent and tailorable photoelectrochemical (PEC) performance endows these Bi2S3 nanostructures with vast potential in solar cell and photodetector applications.
关键词： Photoelectrochemical performance,Morphology control,Nanostructures,Green synthesis,Bismuth sulfide
更新于2025-09-19 17:15:36
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Exfoliation behavior of van der Waals strings: case study of Bi <sub/>2</sub> S <sub/>3</sub>
摘要： The family of crystals constituting covalently bound strings, held together by van der Waals forces, can be exfoliated into smaller entities, similar to crystals made of van der Waals sheets. Depending on the anisotropy of such crystals, and the spacing between their strings in each direction, van der Waals sheets or ribbons can be obtained after the exfoliation process. In this work, we demonstrate that ultra-thin nanoribbons of bismuth sulfide (Bi2S3) can be synthesized via a high power sonication process. The thickness and width of these ribbons are governed by the van der Waals spacings around the strings within the parent crystal. The lengths of the nanoribbons are initially limited by the dimensions of the starting bulk particles. Interestingly, these nanoribbons change stoichiometry, composition and are elongated when the duration of agitation increases, due to Ostwald ripening. An application of the exfoliated van der Waals strings is presented for optical biosensing using photoluminescence of Bi2S3 nanoribbons, reaching detection limits of less than 10 nM L-1 in response to bovine serum albumin. The concept of exfoliating van der Waals strings could be extended to a large class of crystals for creating bodies ranging from sheets to strings, with optoelectronic properties different from that of their bulk counterparts.
关键词： bio-sensing,photo luminescence,van der Waals strings,bismuth sulfide,liquid phase exfoliation,Bi2S3,Ostwald ripening
更新于2025-09-10 09:29:36
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Synthesis of gadolinium-based Bi<sub>2</sub>S<sub>3</sub> nanoparticles as cancer theranostics for dual-modality computed tomography /magnetic resonance imaging-guided photothermal therapy
摘要： Development of a safe, efficient and inexpensive multifunctional nanoplatform using a facile approach for multimodal imaging and therapeutic functions becomes more and more practically relevant but challenging. In this work, we demonstrated a novel nanocomposites (Bi2S3-Gd) for computed tomography (CT)/magnetic resonance (MR) imaging-guided photothermal therapy for cancer in vitro. It was achieved by modification of hydrophobic Bi2S3 with a smart amphiphilic gadolinium-chelated ligand. The as-prepared nanocomposites composed of low cost Bi2S3 and gadolinium complexes, showed high stability, excellent biocompatibility and good photostability. It was observed that Bi2S3-Gd nanocomposites can efficiently convert the NIR light into heat, and then suppressed the growth of tumor cells under NIR laser irradiation. Apart from serving as an effective photothermal agent, the as-prepared nanomaterials could induce an efficient contrast enhancement for both CT and MRI imaging at low concentrations of Bi and Gd, rendering more accurate diagnosis. This work suggests the potential of Bi2S3-Gd nanomaterials as a novel multifunctional nanoplatform for CT/MRI imaging-guided photothermal therapy for cancer.
关键词： photothermal therapy,magnetic resonance imaging,Bismuth sulfide,amphiphilic ligand,computed tomography imaging
更新于2025-09-04 15:30:14