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Zero contrast optical coherence tomography–guided percutaneous coronary intervention for in-stent restenosis of the saphenous vein graft using a non-contrast flush medium
摘要： Percutaneous coronary intervention (PCI) is often denied for individuals with coronary artery disease who are prone to develop contrast-induced acute kidney injury. We report a 73-year-old, stage 3 chronic kidney disease patient (CKD), who underwent coronary artery bypass surgery and saphenous vein graft (SVG) stenting in the past, presented with in-stent restenosis (ISR) of SVG stent. Zero contrast optical coherence tomography (OCT) guidedePCI was successfully performed using low molecular weight dextran-40 (LMWD-40) as the ?ush medium. Our report suggests the safety and feasibility of LMWD-40 ebased OCT-guided zero contrast PCI in ISR of SVG in a CKD patient, although further prospective studies are needed to evaluate this technique.
关键词： Zero contrast,Chronic kidney disease,Dextran-40,Contrast induced-Acute kidney injury,Percutaneous coronary intervention,Optical coherence tomography
更新于2025-09-23 15:23:52
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Sensitive, selective and rapid ammonia-sensing by gold nanoparticle-sensitized V2O5/CuWO4 heterojunctions for exhaled breath analysis
摘要： Marigold flower-like V2O5/CuWO4 heterojunctions were synthesized and its volatile organic compound (VOC)-sensing properties were tested and significantly enhanced after sensitizing by Au nanoparticles. Detailed characterizations were carried out by SEM, XRD and XPS to determine the morphology, crystal structure, elemental and chemical composition of the sensing materials, respectively. The fabricated gold-sensitized sensor was found to be rapidly responsive (a few seconds), highly sensitive to ammonia with good selectivity as compared to various types of VOCs. The limit of detection and linear range of sensor at 150°C were 212 ppb and 5-158 ppm, respectively, which is suitable for detection of exhaled breath ammonia of patients at their last stage of chronic kidney disease. Furthermore, it was found to be of high intra-day repeatability, which is properly explained by discussing the mechanism of NH3 sensing. Very long-term stability of the sensor was investigated over 56 days, once a week.
关键词： Ammonia-sensing,chronic kidney disease,exhaled breath analysis,Au-sensitized V2O5/CuWO4 heterojunctions
更新于2025-09-19 17:13:59
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Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography
摘要： Adriamycin (doxorubicin), a common cancer chemotherapeutic drug, can be used to induce a model of chronic progressive glomerular disease in rodents. In our studies, we evaluated renal changes in a rat model after Adriamycin injection using two-photon microscopy (TPM), optical coherence tomography (OCT) and Doppler OCT (DOCT). Taking advantage of deep penetration and fast scanning speed for three-dimensional (3D) label-free imaging, OCT/DOCT system was able to reveal glomerular and tubular pathology noninvasively and in real time. By imaging renal pathology following the infusion of °uorophore-labeled dextrans of di?erent molecular weights, TPM can provide direct views of glomerular and tubular °ow dynamics with the onset and progression of renal disease. Speciˉcally, glomerular permeability and ˉltration, proximal and distal tubular °ow dynamics can be revealed. 6–8 weeks after injection of Adriamycin, TPM and OCT/DOCT imaging revealed glomerular sclerosis, compromised °ow across the glomerular wall, tubular atrophy, tubular dilation, and variable intra-tubular °ow dynamics. Our results indicate that TPM and OCT/DOCT provide real-time imaging of renal pathology in vivo that has not been previously available using conventional microscopic procedures.
关键词： Two-photon Microscopy (TPM),Chronic kidney disease (CKD),Tubular Atrophy,glomerulosclerosis,Optical Coherence Tomography (OCT)
更新于2025-09-11 14:15:04
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Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging
摘要： Objective To explore the value of texture analysis based on diffusion-weighted imaging (DWI), blood oxygen level–dependent MRI (BOLD), and susceptibility-weighted imaging (SWI) in evaluating renal dysfunction. Methods Seventy-two patients (mean age 53.72 ± 13.46 years) underwent MRI consisting of DWI, BOLD, and SWI. According to their estimated glomerular filtration rate (eGFR), the patients were classified into either severe renal function impairment (sRI, eGFR < 30 mL/min/1.73 m2), non-severe renal function impairment (non-sRI, eGFR ≥ 30 mL/min/1.73 m2, and < 80 mL/min/1.73 m2), or control (CG, eGFR ≥ 80 mL/min/1.73 m2) groups. Thirteen texture features were extracted and then were analyzed to select the most valuable for discerning the three groups with each imaging method. A ROC curve was performed to compare the capacities of the features to differentiate non-sRI from sRI or CG. Results Six features proved to be the most valuable for assessing renal dysfunction: 0.25QuantileDWI, 0.5QuantileDWI, HomogeneityDWI, EntropyBOLD, SkewnessSWI, and CorrelationSWI. Three features derived from DWI (0.25QuantileDWI, 0.5QuantileDWI, and HomogeneityDWI) were smaller in sRI than in non-sRI; EntropyBOLD and CorrelationSWI were smaller in non-sRI than in CG (p < 0.05). 0.25QuantileDWI, 0.5QuantileDWI, and HomogeneityDWI showed similar capacities for differentiating sRI from non-sRI. Similarly, EntropyBOLD and CorrelationSWI showed equal capacities for differentiating non-sRI from CG. Conclusion Texture analysis based on DWI, BOLD, and SWI can assist in assessing renal dysfunction, and texture features based on BOLD and SWI may be suitable for assessing renal dysfunction during early stages.
关键词： Chronic kidney disease,Image processing, computer-assisted,Diffusion magnetic resonance imaging,Chronic renal insufficiency
更新于2025-09-04 15:30:14
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Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
摘要： Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have been captured every week up to eight weeks. Tubular diameter and hypertrophic tubule population of the kidneys at multiple time points after ADR injection have been evaluated through a fully automated computer-vision system. Results revealed that mean tubular diameter and hypertrophic tubule population increase with time in post-ADR injection period. The results suggest that OCT images of the kidney contain abundant information about kidney histopathology. Fully automated computer-aided diagnosis based on OCT has the potential for clinical evaluation of CKD conditions.
关键词： chronic kidney disease,optical coherence tomography,medical image processing,proximal convolutional tubule
更新于2025-09-04 15:30:14