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- 摘要
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- 实验方案
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Deep learning enables cross-modality super-resolution in fluorescence microscopy
摘要： We present deep-learning-enabled super-resolution across different fluorescence microscopy modalities. This data-driven approach does not require numerical modeling of the imaging process or the estimation of a point-spread-function, and is based on training a generative adversarial network (GAN) to transform diffraction-limited input images into super-resolved ones. Using this framework, we improve the resolution of wide-field images acquired with low-numerical-aperture objectives, matching the resolution that is acquired using high-numerical-aperture objectives. We also demonstrate cross-modality super-resolution, transforming confocal microscopy images to match the resolution acquired with a stimulated emission depletion (STED) microscope. We further demonstrate that total internal reflection fluorescence (TIRF) microscopy images of subcellular structures within cells and tissues can be transformed to match the results obtained with a TIRF-based structured illumination microscope. The deep network rapidly outputs these super-resolved images, without any iterations or parameter search, and could serve to democratize super-resolution imaging.
关键词： GAN,cross-modality,super-resolution,fluorescence microscopy,deep learning
更新于2025-11-21 11:24:58
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[ACM Press SIGGRAPH Asia 2018 Virtual & Augmented Reality - Tokyo, Japan (2018.12.04-2018.12.07)] SIGGRAPH Asia 2018 Virtual & Augmented Reality on - SA '18 - Flow zone
摘要： Many people want to live a happy and fulfilling life, yet finding this positive sense of well-being is often quite a challenge. Flow is a wonderfully powerful experience that not only feels amazing in the moment but actually improves a person’s general sense of well-being as well. It seems like a great answer to this problem, but unfortunately the complex concoction of parameters necessary to enter flow prevent the experience from occurring regularly. Flow Zone aims to lower the barrier to entry with its sophisticated design tailored to maximize potential for flow. VR was used as the medium to create an immersive environment that simultaneously removes distractions and focuses the player’s attention on the task at hand. The enhanced immersiveness of cross-modality combined with game design elements centered around creative expression through music creates a streamlined pathway to the flow state.
关键词： Immersion,Cross-Modality,Music,Positive Technology,Flow,Virtual Reality,Well-Being
更新于2025-09-09 09:28:46