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[EAI/Springer Innovations in Communication and Computing] Mobile Solutions and Their Usefulness in Everyday Life || Smartphone Sensing Technologies for Tailored Parkinson’s Disease Diagnosis and Monitoring
摘要： Parkinsonian syndromes are a heterogeneous entity of movement disorders, with various described subtypes. This systematic review aimed to examine the available literature on smartphone applications for assessment of Parkinson’s disease motor and nonmotor symptoms and signs. Papers published from 2013 to 2017, listed in two electronic databases—IEEE Xplore and PubMed—were searched, to identify the works related with smartphone use for PD patients’ diagnosis and monitoring. Full-text articles were analyzed to evaluate the quality of the reported methods and results, considering the validity, reliability, and sensitivity of the techniques used in the measurements as well as the Grading of Recommendations Assessment, Development and Evaluation guideline. The data from 26 full-text articles suggest that many and relevant data can be collected automatically and accurately via mobile phone. Inertial measurement units as well as capacitive, force/pressure, acoustic sensors were used for the development of smartphone-based tools to improve assessment and monitor symptoms and signs of Parkinson’s disease. Smartphone-based information on upper limbs tremor, gait, posture, balance, activities, and speech may improve quality of healthcare services for Parkinson’s disease patients and their quality of life.
关键词： diagnosis,Parkinson’s disease,motor symptoms,nonmotor symptoms,smartphone applications,monitoring
更新于2025-09-04 15:30:14
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Decrease in interpretation time for both novice and experienced readers using a concurrent computer-aided detection system for digital breast tomosynthesis
摘要： Objectives To compare the diagnostic performance and interpretation time of digital breast tomosynthesis (DBT) for both novice and experienced readers with and without using a computer-aided detection (CAD) system for concurrent read. Methods CAD system was developed for concurrent read in DBT interpretation. In this observer performance study, we used an enriched sample of 100 DBT cases including 70 with and 30 without breast cancers. Image interpretation was performed by four radiologists with different experience levels (two experienced and two novice). Each reader completed two reading sessions (at a minimum 2-month interval), once with and once without CAD. Three different rating scales were used to record each reader’s interpretation. Reader performance with and without CAD was reported and compared for each radiologist. Reading time for each case was also recorded. Results Average area under the receiver operating characteristic curve values for BI-RADS scale on using CAD were 0.778 and 0.776 without using CAD, demonstrating no statistically significant differences. Results were consistent when the probability of malignancy and percentage probability of malignancy scales were used. Reading times per case were 72.07 s and 62.03 s (SD, 37.54 s vs 34.38 s) without and with CAD, respectively. The average difference in reading time on using CAD was a statistically significant decrease of 10.04 ± 1.85 s, providing 14% decrease in time. The time-reducing effect was consistently observed in both novice and experienced readers. Conclusion DBT combined with CAD reduced interpretation time without diagnostic performance loss to novice and experienced readers.
关键词： Computer-assisted diagnosis,Digital breast tomosynthesis,Breast cancer
更新于2025-09-04 15:30:14
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Design and validation of a wide-field mobile phone microscope for the diagnosis of schistosomiasis
摘要： Schistosomiasis is a Neglected Tropical Disease that affects over 200 million people worldwide, with children, and the impoverished living in rural African communities disproportionately affected. Schistosomiasis is also a diagnosis occasionally seen in returned travellers, and in particular, adventure travellers. Chronic infection with S. mansoni and S. haematobium leads to significant gastrointestinal or genitourinary pathology, respectively. The diagnosis of S. haematobium and S. mansoni typically involves detecting parasite eggs in urine or faeces, respectively. Conventional light microscopy is the most common diagnostic technique, however laboratory infrastructure, qualified laboratory technicians, and permanent energy sources are limited in many schistosomiasis-endemic regions, making microscopy unavailable to most affected communities. Here we present images of S. haematobium and S. mansoni eggs captured by a novel, smartphone-based microscope designed with a wide field of view, during an epidemiologic survey in the Azaguié region of southern C?te d’Ivoire.
关键词： Global health,Point of care,Mobile phone,Microscope,Diagnosis,Schistosomiasis
更新于2025-09-04 15:30:14
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Selectively light-up hydrogen peroxide in hypoxic cancer cells with a novel fluorescent probe
摘要： A novel fluorescent turn-on probe (HCyHP) was developed in a simple two-step synthesis for monitoring of exogenous and endogenous H2O2 levels in biological samples and hypoxic cancer diagnosis.
关键词： hypoxic cancer cells,fluorescent probe,hydrogen peroxide,bioimaging,diagnosis
更新于2025-09-04 15:30:14
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Influence of Water Molecules on the Detection of Volatile Organic Compounds (VOC) Cancer Biomarkers by Nanocomposite Quantum Resistive Vapor Sensors vQRS
摘要： The anticipated diagnosis of various fatal diseases from the analysis of volatile organic compounds (VOC) biomarkers of the volatolome is the object of very dynamic research. Nanocomposite-based quantum resistive vapor sensors (vQRS) exhibit strong advantages in the detection of biomarkers, as they can operate at room temperature with low consumption and sub ppm (part per million) sensitivity. However, to meet this application they need to detect some ppm or less amounts of biomarkers in patients' breath, skin, or urine in complex blends of numerous VOC, most of the time hindered by a huge amount of water molecules. Therefore, it is crucial to analyze the effects of moisture on the chemo-resistive sensing behavior of carbon nanotubes based vQRS. We show that in the presence of water molecules, the sensors cannot detect the right amount of VOC molecules present in their environment. These perturbations of the detection mechanism are found to depend on the chemical interactions between water and other VOC molecules, but also on their competitive absorption on sensors receptive sites, located at the nanojunctions of the conductive architecture. This complex phenomenon studied with down to 12.5 ppm of acetone, ethanol, butanone, toluene, and cyclohexane mixed with 100 ppm of water was worth to investigate in the prospect of future developments of devices analysing real breath samples in which water can reach a concentration of 6%.
关键词： conductive polymer nanocomposites,anticipated diagnosis,effects of humidity,VOC,quantum resistive vapor sensors,functionalized carbon nanotubes,biomarkers detection
更新于2025-09-04 15:30:14
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A teleophthalmology system for the diagnosis of ocular urgency in remote areas of Brazil
摘要： Purposes: To validate a teleophthalmology mobile system aimed at improving and providing eye urgency screenings in remote and poor area settings in Brazil. The system enables one or more ophthalmologists to remotely examine a patient’s condition and submit a decision describing the gravity of the case. If necessary, the patient can be forwarded to a hospital for further consultation. Methods: A cellphone (Nexus One model, with a 5 megapixel camera) was used to collect data and pictures from 100 randomly selected patients at the Ophthalmology Emergency Room located at the General Hospital of the Federal University of S?o Paulo (UNIFESP). Data was then sent remotely to an online recording system to be reviewed by an ophthalmologist who provided feedback regarding the state of ocular urgency. Results were then compared to the gold standard diagnosis provided at the hospital. Results: The diagnosis of urgency was given by two ophthalmologists: one in the hospital (gold standard) and one remotely. When we compared both diagnoses we obtained results of 81.94% specificity, 92.85% sensitivity, and 85% accuracy, with a negative predictive value of 96.72%. This work also included a processing time analysis, resulting in an average time of 8.6 min per patient for remote consultations. Conclusions: This study is the first that has used only a cellphone for diagnosing the urgency of ocular cases. Based on our results, the system can provide a reliable distinction between urgent and non-urgent situations and can offer a viable alternative for the servicing of underprivileged areas. In screening techniques, the most important outcome is to identify urgent cases with a high level of sensitivity and predictive negative value. Thus, our results demonstrate that this tool is robust and we suggest that a major study aimed to verify its efficiency in resource-poor areas should be initiated.
关键词： Diffusion of innovation,Telemedicine,Remote consultation,Ophthalmology,Eye diseases/diagnosis,Triage
更新于2025-09-04 15:30:14
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Fluorescence-Guided Cancer Diagnosis and Surgery by a Zero Cross-Talk Ratiometric Near-Infrared γ-Glutamytranspeptidase Fluorescent Probe
摘要： The ability to early detect cancer in an accurate and rapid fashion is of critical importance for cancer diagnosis and accurate resection in surgery. γ-Glutamyltranspeptidase (GGT) is overexpressed in several human cancers while keeps low expression in normal microenvironment, and thus recognized as an important cancer biomarker. To date, rational design of a zero cross-talk ratiometric near-infrared (NIR) GGT fluorescent probe for efficiently cancer diagnosis in various biological samples is still a big challenge. In this work, a zero cross-talk ratiometric NIR GGT fluorescent probe named Cy-GSH is developed. Cy-GSH shows highly sensitive to GGT, which is desired for cancer early diagnosis. Upon additional GGT, a large emission shift from 805 nm to 640 nm is observed, which is suitable for visualizing deeply located cancer in vivo. In addition, successful monitoring GGT activity in bloods, cells, tissues and in vivo, makes Cy-GSH possess great potentials for the clinical cancer early diagnosis. Furthermore, accurate visualizing tumors and metastases in mouse models illuminates that the probe may be a convenient tool for fluorescence-guided cancer surgery. To our knowledge, this is the first report to describe the strategy of a zero cross-talk ratiometric NIR GGT fluorescent probe for cancer early diagnosis and fluorescence-guided surgery.
关键词： fluorescent probe,γ-Glutamyltranspeptidase,GGT,cancer diagnosis,fluorescence-guided surgery
更新于2025-09-04 15:30:14
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[IEEE 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) - Taichung, Taiwan (2018.10.29-2018.10.31)] 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) - Nonlinear CMOS Image Sensor with SOC Integrated Local Contrast Stretch for Bio-Microfluidic Imaging
摘要： a nonlinear single-slope ADC with SOC integrated local contrast stretch using a configurable multi-frequency counter for bio-microfluidic imaging is presented in this paper. Compared with the conventional off-chip global contrast stretching algorithm, this method does not degrade image quality at the interested light intensity range (cell) at the cost of unconsidered range (sheath fluid) and can be integrated into CMOS image sensor directly. Meanwhile, this method provides higher precision of cell image for the later super-resolution reconstruction. The simulation results indicate that more details of cell image can be obtained in this method.
关键词： contrast stretch,CMOS image sensor,point-of-care (POC) diagnosis,bio-microfluidic imaging
更新于2025-09-04 15:30:14
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An ellipsoid convex enhancement filter for detection of asymptomatic intracranial aneurysm candidates in CAD frameworks
摘要： Various kinds of enhancement filters have been developed in computer-aided diagnostic (CAD) frameworks for asymptomatic intracranial aneurysms in magnetic resonance angiography (MRA). However, many bending or branching portions on vessels are also enhanced by the conventional filters as false positives in 3.0 T MRA, which can visualize smaller vessels compared with 1.5 T MRA. To overcome this problem, this study focused on developing an ellipsoid convex enhancement (ECE) filter, which can selectively enhance aneurysms while reducing false positive contrasts on bending or branching portions on vessels, for detection of asymptomatic intracranial aneurysm candidates in CAD frameworks. The ECE filter was mathematically designed to enhance various convex regions in the intensity space such as convex aneurysms, in which the ratio of the shortest and longest diameters for aneurysms corresponds to the ratio of reciprocals of the square roots of the first and third eigenvalues of a Hessian matrix. The proposed ECE filter was evaluated by measuring an average contrast for false positive models and free-response receiver operating characteristic curves between two simple CAD frameworks using the ECE and conventional filters based on a leave-one-out-by-patient test. MRA images for thirty patients (male: 10, female: 20; age: 48–86 yr, mean: 69.2) with 31 unruptured aneurysms (longest diameter: 2.0–5.5 mm, mean: 3.7 mm) were selected for this study. The average contrast for false positive models was reduced by 51.4% using the ECE filter, compared with the conventional filter for the convex regions with ratios of the shortest and longest diameters less than 0.4. The number of false positives per case was decreased from 41.1 to 22.8 on average at a sensitivity of 87% by using the ECE filter. The ECE filter would be useful for boosting the performance of the CAD framework of asymptomatic intracranial aneurysms by providing higher contrast aneurysms and lower contrast false positives such as bending or branching portions on vessels.
关键词： unruptured intracranial aneurysm,ellipsoid convex enhancement (ECE) filter,magnetic resonance angiography (MRA),computer-aided diagnosis (CAD)
更新于2025-09-04 15:30:14