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FR - Utilidad del láser de colorante pulsado en el lupus eritematoso cutáneo
摘要： El lupus eritematoso cutáneo (LEC) es una enfermedad autoinmune heterogénea con manifestaciones clínicas muy variables, desde lesiones cutáneas aisladas hasta una afectación sistémica grave. Existen, por tanto, diferentes subtipos con características clínicas, histológicas y analíticas bien definidas, siendo constante en todos ellos la afectación cutánea1. Atendiendo a la guía de tratamiento del LEC elaborada por el European Dermatology Forum en 2017 llama la atención que el tratamiento con láser de lesiones activas del LEC estaría desaconsejado. En dicho manuscrito se especifica que este podría ser usado como un tratamiento complementario solo en caso de ser administrado por un dermatólogo acreditado y en lesiones muy seleccionadas (telangiectasias)2. Esta recomendación contrasta de forma notable con lo descrito en la literatura hasta el momento. Desde que en 1986 Henderson et al. aplicaran con éxito láser CO2 a una paciente con lupus eritematoso discoide desfigurante, han sido múltiples los autores que han publicado casos tratados de forma satisfactoria con estos dispositivos3. Este láser junto con el láser argón mejoraban las lesiones cutáneas de los pacientes a expensas de efectos secundarios indeseados4. En contraposición, el láser de colorante pulsado (LCP), el más utilizado para el tratamiento del LEC, ha demostrado unos excelentes resultados (mejorías entre el 60-88%) con mínimos efectos secundarios (dolor, alteraciones de la pigmentación). Este láser permite tratar no solo las telangiectasias que exhiben estos pacientes, sino también el componente eritemato-edematoso con mejoría clínica, histológica y de la sintomatología asociada. Ha sido empleado con éxito en pacientes con lupus eritematoso crónico (discoide, tumidus) y subagudo, ofreciendo buenos resultados tanto en lesiones recalcitrantes que no responden a tratamientos tópicos y sistémicos, como en lesiones agudas, minimizando el riesgo de cicatrices secundarias5. Otras fuentes de luz como el láser Nd:YAG y la luz pulsada intensa han demostrado de forma puntual ser útiles en esta enfermedad, no obstante la evidencia aun es escasa. La seguridad del tratamiento con LCP en pacientes con lupus ha sido un tema ampliamente debatido. Este láser, con longitud de onda de 595 nm, se encuentra fuera del espectro ultravioleta de radiación, el cual es responsable de la fotosensibilidad de los pacientes con lupus. Además, el riesgo de inducir nuevas lesiones por un efecto Koebner no ha sido constatado hasta el momento. El mecanismo por el cual el LCP resulta efectivo no está del todo claro. La hipótesis que formulan la mayoría de autores se basa en una destrucción selectiva de la microvasculatura de las lesiones del LEC, lo cual ocasionaría una reducción del ambiente inflamatorio y la consecuente mejoría clínica e histológica6. En ocasiones los pacientes con LEC reciben altas dosis de fármacos inmunosupresores (tópicos y sistémicos) con respuestas poco satisfactorias y efectos secundarios nada desde?ables. Resulta importante que los dermatólogos conozcamos esta alternativa terapéutica pese a no estar estandarizada en las guías clínicas o algoritmos, dado su potencial y bajo perfil de efectos secundarios. De igual modo serían necesarios futuros estudios sobre la utilidad del LCP en el LEC, con el objetivo de poder ofrecer este tratamiento con un grado de recomendación apropiado.
关键词： Cutaneous lupus erythematosus,Discoid lupus,Subacute lupus,Therapeutics,Tumidus lupus,Pulsed dye laser
更新于2025-09-23 15:23:52
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Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma
摘要： Clinical efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser in the treatment of children with hemangioma was analyzed, to provide a new therapeutic idea for their clinical treatment. A total of 120 children with hemangioma were selected into the study. Children treated with propranolol combined with pulsed dye laser were in group A, those treated with pingyangmycin combined with pulsed dye laser were in group B, and 60 healthy children were selected as control group (group C). Blood samples of children were taken before and after treatment for miR?4295 detection. The expression of miR?4295 was observed after treatment, and the total clinical remission rate and adverse reactions after treatment were compared between the two groups. The tumor volume of the two groups was significantly reduced after treatment, with statistically significant difference (P<0.05); miR?4295 expression was reduced in the two groups (P<0.05); adverse reactions in propranolol group were less than pingyangmycin group during treatment (P<0.05). Propranolol and pingyangmycin, respectively, combined with pulsed dye laser had ideal efficacy on hemangioma in children. Moreover, miR?4295 was highly expressed in children with hemangioma, and the expression level reduced after two methods of treatment. However, adverse reactions in propranolol group were less and its safety was higher.
关键词： pingyangmycin,miR?4295,children with hemangioma,pulsed dye laser
更新于2025-09-23 15:21:01
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Combined pulsed dye laser and systemic retinoids for the treatment of hypertrophic resistant warts among organ transplant patients
摘要： In this retrospective cohort study, we aimed to evaluate the efficacy and safety of a combined regimen of PDL and systemic retinoids in the treatment of recalcitrant warts among OTR.
关键词： Organ transplant patients,Pulsed dye laser,Systemic retinoids,Hypertrophic resistant warts
更新于2025-09-23 15:21:01
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Development of a composite polymer-dye medium for tunable laser emission
摘要： We demonstrate optically pumped laser medium with emission in the visible spectral range from binary solutions of Rhodamine 6G and Rhodamine B in epoxy resin as matrix without appending additional scattering centers. A frequency doubled Q-switched Nd: YAG laser was used for pumping. The generation’s behavior is similar to random laser (RL) with no external optical resonator. The in?uence of the nanostructured morphology of the medium on the laser properties was investigated by means of SEM, AFM, TEM, SAED, Spectro?uorimetry and Spectrometry. The laser emission is characterized by high intensity – energy per pulse – 300 μJ, threshold pump energy 1.7 mJ, relatively low beam divergence of 70 mrad (for RL) and spectrally narrowed major peak at 597 nm. The new gain medium was also investigated in a conventional tunable resonator. Generation with continuous tuning in the spectral range 590–610 nm was obtained. This new e?ective nanostructured medium, which shows with high optical and energy parameters, can be used in speckle-free laser imaging, time-resolved microscopy, high speed optical converters and others photonics applications.
关键词： Dye laser,Tunable laser,Broadband laser,Random laser,Epoxy resin
更新于2025-09-23 15:19:57
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The clinical and electron microscopic evaluation of the impact of pulsed dye laser techniques on solar lentigines (randomized clinical trial)
摘要： Background: Solar lentigines are skin lesions manifested by benign dark pigmentation causing a cosmetic problem in many patients. Several treatment modalities used for the management of solar lentigines. Side effects and rates of recurrence may be associated with them. Objective: Treating solar lentigines with two different techniques of pulsed dye laser and evaluation of the results both clinically and via the examination of ultrastructural changes by electron microscopy. Patients and methods: This study was conducted on twenty-two subjects with solar lentigines and having Fitzpatrick III-IV skin types, was managed by the use of pulsed dye laser after enrolling them into two groups. Group I (one stacked pulsed dye laser was used) and Group II (treated by stacked pulsed dye laser in two sessions, one month apart). At baseline and six months after treatment, two punch biopsies with a diameter of 2mm were taken from all patients. All taken biopsies were prepared for light and electron microscopic examinations. Results: Both pulsed dye laser techniques induced significant better clinical and histological outcomes. No one demonstrated any postoperative complications such as post-inflammatory hyperpigmentation and scarring. Conclusion: The two techniques of pulsed dye laser are efficient for solar lentigines treatment.
关键词： Pulsed Dye laser,ultrastuctural study,Solar lentigines,Electron Microscope
更新于2025-09-23 15:19:57
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Measurement of photoionization cross-section of Li (2p, 3d) excited states using thermionic diode detector
摘要： Studies on photoionization cross-section measurement of lithium 2p and 3d excited states selectively populated by single and two photons are reported. The photoionization is carried out in a heat-pipe cum thermionic diode detector using nitrogen laser pumped pulsed dye laser. Rhodamine perchlorate (Rh-640) dye is used to generate the desired tunable laser output in the range of 635 to 675 nm. Both, the thermionic diode detector and dye laser are developed in-house. A negative space charge region formed around diode cathode filament is illuminated by dye laser exciting pulse followed by ionizing UV radiation from nitrogen laser. The effect of ionizing laser pulse energy and precise tuning of dye laser on photoionization signal, across 670.780 nm (2S1/2 → 2P1/2,3/2) single-photon transition and 639.145 nm (2S1/2 → 2D3/2,5/2) two-photon transition are studied. The results obtained are compared with model calculations of photoionization signal saturation curve. The ionization cross-section for both the states (2P1/2, 2D5/2) are determined as 15.40 ± 2.8 Mb and 8.04 ± 1.6 Mb, respectively and atomic number density N ～ 5.6 × 10^8 (cm^?3).
关键词： Dye laser,Photoionization cross-section,Thermionic diode,Heat-pipe,Lithium
更新于2025-09-19 17:15:36
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Retrospective study of photodynamic therapy for pulsed dye lasera??resistant porta??wine stains
摘要： Pulsed dye laser-resistant port-wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser-resistant cervicofacial port-wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532-nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port-wine stain lesions were evaluated according to the L*a*b* color coordinate system, then the values of color changes (DE) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median DE decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2-month follow up (P < 0.001). The median blanching rate of port-wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (>50% color blanching). Adverse events were minimal, transient and self-limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser-resistant port-wine stains.
关键词： pulsed dye laser,pulsed dye laser resistance,treatment efficacy,photodynamic therapy,port-wine stain
更新于2025-09-19 17:13:59
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Pulse Dye Laser Therapy Successful for Elastosis Perforans Serpiginosa
摘要： Background. We describe a case of elastosis perforans serpiginosa and its successful management with PDL laser. Case Presentation. A 15-year-old male presented with a history of itchy, raised, red and unsightly lesions on the back of his neck. He was diagnosed with Elastosis Perforans Serpiginosa on tissue biopsy and underwent pulse dye laser therapy over four years with excellent results. Conclusions. Our results show that pulse dye laser therapy is a safe and effective treatment for elastosis perforans serpiginosa.
关键词： elastosis perforans serpiginosa,dermatological medicine,pulse dye laser therapy
更新于2025-09-19 17:13:59
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Pulsed dye laser alone versus its combination with topical ivermectin 1% in treatment of Rosacea: a randomized comparative study
摘要： Background While the aetiology of rosacea is multifactorial, it is not surprising that treatment has been controversial. Pulsed dye laser (PDL) has been successfully used to treat vascular components of rosacea. Ivermectin 1% cream is an emerging treatment. Objective To provide a comprehensive clinical and dermatoscopic comparative study between the efficacy and safety of pulsed dye laser alone versus its combination with topical ivermectin 1% in the treatment of rosacea. Materials and methods Thirty Patients were randomly divided into two groups. Group A (n=15) treated with 585 nm PDL, and group B (n=15) treated with 585 nm PDL and topical ivermectin 1% cream. All patients received four laser treatments with a 4-week interval. The efficacy of treatment was assessed by photographs and dermoscopic photomicrographs at baseline and 3 months after the final treatment. The patient’s level of satisfaction was also recorded. Results At the 3-month follow-up, group B induced better clinical improvement than group A. However, this difference was not significant. No serious adverse events were observed in either treatment group. Conclusion This study supports the efficacy of PDL treatment for patients with rosacea. PDL could be more effective when combined with ivermectin 1% cream.
关键词： Rosacea,ivermectin,pulsed dye laser
更新于2025-09-19 17:13:59
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[IEEE 2019 Workshop on Recent Advances in Photonics (WRAP) - Guwahati, India (2019.12.13-2019.12.14)] 2019 Workshop on Recent Advances in Photonics (WRAP) - Development of micro dye laser based on micro wire molding technique
摘要： Three dimensional microfluidic dye laser inside PDMS has been fabricated by microwire molding technique. Visible laser emission from micro-laser was achieved in a micro-laser of 1mM R6G dye dissolved in a mixture of ethanol and benzyl alcohol as the active medium. The laser output intensity profile and variation of the output with the pump power was studied and a threshold of 4.5 mW pump power was observed.
关键词： microwire molding technique,Micro dye laser,Microchannel,PDMS
更新于2025-09-19 17:13:59