- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold
摘要： Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm?2, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.
关键词： Antiangiogenesis therapy,Gold nanobipyramids,Plasmon resonance,Core@shell nanostructures,Photothermal therapy
更新于2025-11-21 11:24:58
-
Gold Nanobipyramid Enveloped in Alloyed Nanoshell for Stable Plasmonic Sensors
摘要： Compared to monometallic nanoparticles, alloyed and bimetallic nanostructures are of great interest for their high stability and improved physicochemical properties. In this work, an effective method has been developed to obtain core-shell nanorods, in which the core is uniform gold nanobipyramids (AuBPs) enveloped in AuxAg1-x alloyed nanoshell. The penta-twinned AuBP@AuxAg1-x nanorods with x ranging from 0 to 1 integrate the advantages of AuBPs core and AuAg alloy shell effectively. Specifically, they combine the superiority of Au and Ag, exhibiting excellent both thermal and chemical stability, high refractive index sensitivity, and stable surface-enhanced Raman scattering (SERS) effect in harsh environment. Furthermore, the surface plasmon resonance of AuBP@AuxAg1-xNRs could be finely tailored in a large wavelength region with a narrow full width at half maximum (FWHM) by simply varying the alloy shell thickness and the AuBPs core size. These improved properties offer the obtained core-shell nanostructures novel and viable perspectives in severe environments. The simple and feasible synthetic strategy is also versatile to fabricate other noble metallic nanostructures enveloped in alloyed nanoshell.
关键词： sensitivity,alloy nanoshell,gold nanobipyramids,stability,optical property
更新于2025-09-19 17:13:59
-
Controlled fabrication of gold nanobipyramids/polypyrrole for shell-isolated nanoparticle-enhanced Raman spectroscopy to detect γ-aminobutyric acid
摘要： Shell-isolated nanoparticle-enhanced Raman Spectroscopy (SHINERS) has been a non-destructive, highly sensitive, specific and powerful sensing method. Detection of γ-aminobutyric acid (GABA) and glutamate, main neurotransmitters in the human brain, is important to diagnosis the neurological disorder. The purpose of this study is preparing a simple, rapid and inexpensive fabrication of Au nanobipyramids/polymer core/shell as a SHINERS-based biosensor to detect different neurotransmitters such as GABA and glutamate with high sensitivity and specificity. Au nanobipyramids/polymer core/shell was fabricated by using two steps process. In the first Au nanobipyramids with longitude and latitude axial of about 100 nm and 10 nm, respectively, was prepared based on the chemical reduction of Au ions by using sodium borohydride as a reducing agent. Then a thin layer of polypyrrole was used for decorating the Au nanobipyramids by using direct polymerization in the presence of Au nanobipyramids. The sensor composed Au nanobipyramids with a thin layer of polypyrrole that could measure GABA within a wide range of concentrations in the presence of human serum. And this sensor was used for direct monitoring of GABA and glutamate. The proposed biosensor can be applied to monitor the level of neurotransmitters accurately for the diagnosis of various neurological disorders with optical signal enhancement.
关键词： Glutamate,Polypyrrole,Gold nanobipyramids,γ-Aminobutyric acid,Shell-isolated nanoparticle-enhanced Raman spectroscopy
更新于2025-09-12 10:27:22
-
Enzyme-free multicolor biosensor based on Cu2+-modified carbon nitride nanosheets and gold nanobipyramids for sensitive detection of neuron specific enolase
摘要： In this work, we have synthesized Cu2+-modified carbon nitride nanosheets (Cu2+-C3N4) as peroxidase mimic catalytic substance, which is more active than the horseradish peroxidase enzyme in extreme environments. Gold nanobipyramid (Au NBP) is a good chromogenic substrate for multicolor display because the longitudinal plasmon bands of AuNRs can be easily tuned by adjusting their aspect ratios and used as an excellent indicator for colorimetric detection of immunoassays. The generation of TMB2+ from sandwich complex (peroxidase-like catalysis) efficiently etches Au NPBs to produce multicolor variations from brown to olive, green, blue, purple, purple, red, pink, and colorless in presence of varied concentrations of neuron specific enolase (NSE). The experimental results show that the colorimetric detection ranging from 312.5 to 20,000 pM with a detection limit of 92.8 pM, which is higher than other multicolor based sensors. The Cu2+-C3N4 nanosheets and Au NBPs based colorimetric visual (naked eye) semi-quantitative method as a potential platform towards the detection of important biomolecules in clinical and therapeutic applications. The proposed method is simple, low-cost and enzyme-free to detect NSE for the first time.
关键词： Gold nanobipyramids,Cu2+-C3N4 nanosheets,Mimic enzyme activity,Neuron specific enolase,Biosensor
更新于2025-09-04 15:30:14