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Ordered assemblies of Fe3O4 and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects
摘要： We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe3O4) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe3O4) exhibited the shortest transversal relaxation time, T2, and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.
关键词： Conjugated polymers,Photoacoustic imaging,Magnetic resonance imaging,Iron oxides,Hybrid nanoparticles
更新于2025-09-23 15:22:29
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Facile synthesis of SiO2@TiO2 hybrid NPs with improved photocatalytic performance
摘要： SiO2@TiO2 hybrid nanoparticles (NPs) were successfully prepared via a simple solvothermal approach using tetrabutyl titanate (Ti(OBu)4) as a titanium source. The morphology and crystal structure of the sample were characterised by scanning electron microscope, transmission electron microscope, and X-ray diffraction. The photocatalytic properties of SiO2@TiO2 hybrid NPs were also investigated in detail. The results showed that the layers of TiO2 NPs have been successfully coated onto the uniform silica sphere and transformed into anatase after calcination at 500°C. In addition, the photocatalytic activity of the as-obtained product was higher than that of the commercial P25-TiO2. The method for producing hybrid NPs has potential applications in building various types of hybrid NPs.
关键词： SiO2@TiO2 hybrid nanoparticles,photocatalytic performance,solvothermal approach,anatase titanium dioxide
更新于2025-09-23 15:21:21
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Therapeutic Fluorescent Hybrid Nanoparticles for Traceable Delivery of Glucocorticoids to Inflammatory Sites
摘要： Treatment of inflammatory disorders with glucocorticoids (GCs) is often accompanied by severe adverse effects. Application of GCs via nanoparticles (NPs), especially those using simple formulations, could possibly improve their delivery to sites of inflammation and therefore their efficacy, minimising the required dose and thus reducing side effects. Here, we present the evaluation of NPs composed of GC betamethasone phosphate (BMP) and the fluorescent dye DY-647 (BMP-IOH-NPs) for improved treatment of inflammation with simultaneous in vivo monitoring of NP delivery. Methods: BMP-IOH-NP uptake by MH-S macrophages was analysed by fluorescence and electron microscopy. Lipopolysaccharide (LPS)-stimulated cells were treated for 48 h with BMP-IOH-NPs (1×10-5-1×10-9 M), BMP or dexamethasone (Dexa). Drug efficacy was assessed by measurement of interleukin 6. Mice with Zymosan-A-induced paw inflammation were intraperitoneally treated with BMP-IOH-NPs (10 mg/kg) and mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI) were treated intranasally with BMP-IOH-NPs, BMP or Dexa (each 2.5 mg/kg). Efficacy was assessed in vivo by paw volume measurements with μCT and ex vivo by measurement of paw weight for Zymosan-A-treated mice, or in the AAI model by in vivo x-ray-based lung function assessment and by cell counts in the bronchoalveolar lavage (BAL) fluid and histology. Delivery of BMP-IOH-NPs to the lungs of AAI mice was monitored by in vivo optical imaging and by fluorescence microscopy. Results: Uptake of BMP-IOH-NPs by MH-S cells was observed during the first 10 min of incubation, with the NP load increasing over time. The anti-inflammatory effect of BMP-IOH-NPs in vitro was dose dependent and higher than that of Dexa or free BMP, confirming efficient release of the drug. In vivo, Zymosan-A-induced paw inflammation was significantly reduced in mice treated with BMP-IOH-NPs. AAI mice that received BMP-IOH-NPs or Dexa but not BMP revealed significantly decreased eosinophil numbers in BALs and reduced immune cell infiltration in lungs. Correspondingly, lung function parameters, which were strongly affected in non-treated AAI mice, were unaffected in AAI mice treated with BMP-IOH-NPs and resembled those of healthy animals. Accumulation of BMP-IOH-NPs within the lungs of AAI mice was detectable by optical imaging for at least 4 h in vivo, where they were preferentially taken up by peribronchial and alveolar M2 macrophages. Conclusion: Our results show that BMP-IOH-NPs can effectively be applied in therapy of inflammatory diseases with at least equal efficacy as the gold standard Dexa, while their delivery can be simultaneously tracked in vivo by fluorescence imaging. BMP-IOH-NPs thus have the potential to reach clinical applications.
关键词： nanoparticle-based therapy,in vivo imaging,inflammatory disease,monitoring glucocorticoid delivery,hybrid nanoparticles
更新于2025-09-19 17:15:36
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Photo-physical studies of ultrasmall upconversion nanoparticles embedded organometallic complexes: Probing a dual mode optical sensor for hydrogen peroxide
摘要： Here, we report an upconversion nanoparticles (UCNPs) embedded organomettalic complex for detection of hydrogen peroxide (H2O2). The structural as well as the optical properties of the hybrid nanoparticles (HNPs) have been studies to confirm the interaction as well as energy transfer mechanism. The structural characterization confirm the weak interacting force between the UCNPs and the organic complex in HNPs. The optical studies reveal that, HNPs show characteristic optical behaviour of both the phases i.e. it gives an intense downconverted red emission under UV excitation, due to the presence of organic part (Eu3t ion) as well as an efficient blue upconverted emission from inorganic part (Tm3t ion) under NIR excitation. The energy transfer between the inorganic (Tm3t ion) and the organic (Eu3t ion) material has been observed, which confirms the effective attachment of both the phases in HNPs. The upconversion and downconversion emission properties, have been have successfully utilized for dual mode H2O2 detection.
关键词： Hydrogen peroxide sensor,Lanthanides,Hybrid nanoparticles,Energy transfer
更新于2025-09-19 17:13:59
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Synthesis of Inorganic/Organic Hybrid Materials via Vapor Deposition onto Liquid Surfaces
摘要： Hybrid materials have a multitude of uses in electronics, catalysis, and drug delivery. Here, we combine sputter deposition and initiated chemical vapor deposition onto low-vapor-pressure liquids to fabricate inorganic/organic hybrid materials. We demonstrate that polymer nanoparticles can be decorated with metal nanoparticles and nanoparticle dispersions can be encapsulated within polymer shells or within gel beads. The generality of our synthetic route allows for a variety of hybrid materials to be fabricated by tuning the viscosity of the liquid, solubility of the monomer, and surface tension of the polymer and liquid.
关键词： encapsulation,polymer,hybrid,nanoparticles,hydrogels,synthesis
更新于2025-09-09 09:28:46
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Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy
摘要： Heretofore, conjugated polymers (CPs) attract considerable attention in photothermal therapy (PTT). Although various CPs with different structures have been reported, the suboptimal circulation persistence and biodistribution limit their efficacy in tumor treatment. Human serum albumin (HSA), an endogenous plasm protein, has been widely functioned as a carrier for therapeutic agents. Herein, we construct nanocomplexs C16 pBDP@HSA NPs from hydrophobic 4, 4-difluoro-4-bora-3a, 4adiaza-s-indacene (BODIPY)-containing CPs and HSA, which exhibit robust stability in physiological conditions and excellent photothermal activity upon irradiation. The high photothermal conversion efficiency of 37.5 %, higher than that of other reported PTT agents such as gold nanorods, phosphorus quantum dots and 2D materials, results in the potent photocytotoxicity towards cancer cells. Simultaneously, C16 pBDP@HSA NPs’ capabilities of near infrared fluorescence and photoacoustic imaging can provide guidance to the PTT. The outstanding inhibition of tumor growth results from great photothermal activity, the benefited accumulation in tumor and optimal timing of treatment. To the best of our knowledge, this is the first study which combines the BODIPY-based CPs and HSA in one nanostructure and finds application in cancer treatment. Moreover, this article also offers a new strategy for other insoluble macromolecules to explore more biomedical applications.
关键词： photothermal therapy,albumin,hybrid nanoparticles,conjugated polymers,BODIPY
更新于2025-09-09 09:28:46