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Ultrasound-Assisted Synthesis and Characterization of Heparin-Coated Eu3+ Doped Hydroxyapatite Luminescent Nanoparticles
摘要： Herein, the heparin-coated Eu3+ doped hydroxyapatite luminescent nanoparticles were synthesized by an ultrasound-assisted coprecipitation method followed with steam sterilization at 121 °C. The effects of ultrasound treatment, steam sterilization, sodium heparin (SH) concentration and Eu doping content on the formation of heparin-coated Eu3+ doped hydroxyapatite nanoparticles (SH-Eu:nHAP) were investigated. The sterilized and suspended Eu-nHAP with improved luminescence and stability was simultaneously achieved in a process of about 2 h due to the combined effect of ultrasonic sonochemistry and stabilization function of SH. The obtained SH-Eu:nHAP suspension shows good stability in water and biological media. Moreover, the SH-Eu:nHAP shows no hemolysis and cytotoxicity, and can be ingested by cells and emit characteristic luminescence in cells. In summary, this study provides an improved method for the synthesis of SH-Eu:nHAP suspension that is helpful for promoting the application of rare earth doped nHAP as bioimaging agent.
关键词： Heparin,Hydroxyapatite nanoparticles,Europium,Luminescence,Bioimaging
更新于2025-09-19 17:15:36
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Laser Ablation - From Fundamentals to Applications || Matrix-Assisted Pulsed Laser Evaporation of Organic Thin Films: Applications in Biology and Chemical Sensors
摘要： Polymer and biomolecule processing for medical and electronics applications, i.e. the fabrication of sensors and biosensors, microarrays, or lab on chip devices is a cornerstone field which shows great promise. Laser based thin film deposition techniques such as pulsed laser deposition or matrix-assisted pulsed laser evaporation (MAPLE) are competing with conventional methods for integrating new materials with tailored properties for novel technological developments. Successful polymer and protein thin film deposition requires several key elements for depositing viable and functional thin films, i.e. the characteristics of the laser depositing system, the choice of targets and receiver substrates, etc. This chapter reviews the following topics: brief presentation of the MAPLE process including several examples of polymer materials deposited by MAPLE, thus illustrating the potential of the technique as a gentle laser-assisted deposition method. In particular, the “synthesis” of new materials, their analysis and correlation of the bulk and interface properties to its bio-environment shall be discussed as a method to tackle some bioengineering issues. We will also focus on recent breakthroughs of the MAPLE technique for the fabrication of functional devices, i.e. sensor devices based either on chemoresponsive polymers or on proteins.
关键词： saw,maple,hydroxyapatite nanoparticles,odorant-binding proteins,PEG-PCL-me,polyethylenimine,polyepichlorohydrin,ha,polyethylene glycol-co-polycaprolactone methyl ether,polyisobutylene,lactoferrin
更新于2025-09-19 17:13:59