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- 摘要
- 关键词
- 实验方案
- 产品
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Interventional Oncology (Principles and Practice of Image-Guided Cancer Therapy) || Principles of high-intensity focused ultrasound
摘要： High-intensity focused ultrasound (HIFU), also known as focused ultrasound (US), is a non-invasive image-guided therapy which has been primarily employed in the clinical realm for non-invasive thermal ablation of benign and malignant neoplasms. Real-time imaging guidance, treatment monitoring, and therapy control are achieved with either US or magnetic resonance imaging (MRI) guidance. HIFU clinical experience has been described in the treatment of leiomyomata (uterine fibroids), prostate (benign prostatic hypertrophy and cancer), breast, hepatic, renal, pancreatic, brain, and bone tumors, although for most of these tumors, relatively small numbers of treated patients have been described and widespread adoption of HIFU thermoablation remains limited. Ongoing technical challenges include the feasibility of treating large tumors within a finite treatment time, treating tumors prone to motion, and accessing targets when the acoustic window is restricted by intervening anatomy (e.g., ribs, bowel).
关键词： image-guided therapy,thermal ablation,HIFU,High-intensity focused ultrasound,non-invasive therapy
更新于2025-09-23 15:21:01
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Interventional Oncology (Principles and Practice of Image-Guided Cancer Therapy) || Imaging in interventional oncology: Role of image guidance
摘要： Advances in medical imaging have created the opportunity for minimally invasive, image-guided oncologic care by allowing: (1) procedure planning; (2) device delivery; (3) intraprocedure monitoring; and (4) therapy assessment. Although most current image-guided therapy still utilizes standard diagnostic imaging equipment, interventional use of imaging equipment has in fact different priorities compared with diagnostic uses of such equipment. Therefore, interventional procedures prioritize imaging equipment that: (1) provides real-time imaging; (2) lowers radiation dose; and (3) provides greater physician access to the patient. In contrast to diagnostic imaging, lower image quality is an acceptable compromise for real-time imaging for interventional procedures. Patients have already undergone high-quality diagnostic imaging when they are referred to interventional therapies. Moreover, high-quality diagnostic imaging may require more time and more radiation dose than fast imaging of a restricted region of interest as performed for image guidance of interventions.
关键词： image-guided therapy,real-time imaging,physician access,medical imaging,radiation dose,interventional oncology
更新于2025-09-23 15:21:01
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Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
摘要： Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region.
关键词： metallacycle,image-guided therapy,supramolecular coordination complexes,second near-infrared region,theranostic
更新于2025-09-19 17:15:36
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Cancer Theranostics || Multimodality Image-Guided Treatment
摘要： Recent advances in molecular biology and imaging technology with precision engineering have allowed in vivo imaging of anatomic structures at submillimeter ranges and pathologic processes at subnanomolar concentrations. Multimodality imaging is exemplified by the current practice of single photon emission computed tomography (SPECT-CT) and positron emission tomography computed tomography (PET-CT) [1]. Subcentimeter lesions on computed tomotraphy (CT) can be characterized by functional abnormalities identified on SPECT to enhance sensitivity of detecting radio-isotopes or PET, which routinely assess lesion glucose metabolism using F-18 FDG (fluorine-18 fluoro-2-fluorodeoxyglucose). Conversely, subcentimeter hypermetabolic lesions on SPECT or PET can be identified on CT to allow exact localization to guide various types of therapy including surgery, radiotherapy, and experimental therapies. Guided therapies target abnormal tissues, which often refer to, but are not limited to, neoplasms. For instance, drainage of an abdominal bacterial abcess may require scintigraphic confirmation of infection to determine the need of intervention and anatomic guidance from CT or magnetic resonance imaging (MRI) to access the lesion.
关键词： Cancer treatment,Radiotherapy,Multimodality imaging,PET-CT,SPECT-CT,Surgery,Image-guided therapy,Molecular imaging
更新于2025-09-10 09:29:36