- 标题
- 摘要
- 关键词
- 实验方案
- 产品
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Implementation of polarization-encoded quantum Toffoli gate
摘要： Optics plays an important role in data processing. In this context, optical nonlinear material is very useful for superfast switching operations. Again polarization-based encoding and decoding technique plays a convenient way for data processing. In this paper, a new method to implement a quantum Toffoli gate with the active use of optical nonlinear material and polarization-based encoding technique is reported.
关键词： Optical nonlinear material,Quantum logic gate,Polarization encoding,Optical computing,Kerr effect
更新于2025-09-09 09:28:46
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Logic Sensing of MicroRNA in Living Cells Using DNA-Programmed Nanoparticle Network with High Signal Gain
摘要： Molecular circuits capable of implementing Boolean logic in cellular environments have emerged as an important tool for in situ sensing, elucidating, and modulating cell functions. The performance of existing molecular computation devices in living cells is limited because of the low level of biomolecular inputs and moderate signal gain. Herein, we devised a new class of DNA-programmed nanoparticle network with integrated molecular computation and signal amplification functions for logic sensing of dual microRNA (miRNA) molecules in living cells. The nanoparticle network, which is composed of DNA-bridged gold nanoparticles and quantum dots (QDs), could simultaneously interface with two miRNA molecules, amplify the molecular inputs, perform a calculation through AND logic gate, and generate QD photoluminescence (PL) as an output signal. Significant improvement in imaging sensitivity is achieved by integrating the signal amplifier into the molecular computation device. It allows discrimination of specific cancer cell type via intelligent sensing of miRNA patterns in living cells.
关键词： assembly,microRNA,DNA,cancer imaging,gold nanoparticle,logic gate,quantum dot
更新于2025-09-09 09:28:46
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A reversible fluorescent probe for directly monitoring protein-small molecules interaction utilizing vibration-induced emission
摘要： The interactions between proteins and small molecules play an important role in the regulation of various cellular processes and modern drug discovery. Herein, we have developed a novel strategy for real-time monitoring the protein-ligand interaction based on vibration-induced emission (VIE) mechanism. These results demonstrated that the probe DPAC-DB could directly visualize the binding process in biotin-avidin system, which was undisturbed to other environmental stimuli, such as pH, interference species and temperature. Furthermore, the unique VIE effect caused by dramatic and reversible intramolecular vibrations enabled our strategy possible to build up the bio-logic gate. This method to efficiently control the emission of VIE-based probe through the reversible noncovalent protein-small molecules interactions opens new avenues for the development of potent protein pharmaceuticals and small molecule drugs.
关键词： Reversible,Vibration-induced emission (VIE),Biotin-avidin system,Bio-logic gate
更新于2025-09-04 15:30:14