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Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2
摘要： Purpose To evaluate the retinal and choroidal vascular changes through optical coherence tomography angiography (OCTA) in patients with macular telangiectasia type 2 (MacTel 2). Methods Our study included 20 patients (40 eyes) with MacTel 2, and age-matched and sex-matched 18 subjects (36 eyes) in the control group. Fundus color photographs, fundus autofluorescence, fundus fluorescein angiography, spectral-domain optical coherence tomography and OCTA were performed. Foveal vascular density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness, choroidal thickness (CT) and retinal ganglion cell–inner plexiform layer (GCIPL) were compared between MacTel 2 patients and normal age-matched controls. Results The retinal whole vascular density and PFVD of the deep plexus were significantly lower in patients with MacTel 2 than that of the control group (56.93% vs. 58.54%, p = 0.003; and 60.38% vs. 61.66%, p = 0.045). The foveal avascular zone (FAZ) of the deep plexus was significantly enlarged in patients with MacTel 2 than that of the control group (0.44 vs. 0.36, p = 0.009). There was a positive and statistically significant correlation between the FAZ of the superficial and deep plexus and CT in patients with MacTel 2. There was a positive and statistically significant correlation between retinal whole, parafoveal temporal quadrant vascular density of the superficial and deep plexus and GCIPL thickness in patients with MacTel 2. Conclusions Our study demonstrated that important retinal vascular density and FAZ changes in MacTel 2 occur in the deep capillary plexus of the retina.
关键词： Macular telangiectasia type 2,Vascular density,Choroidal thickness,Retinal ganglion cell–inner plexiform layer,Optical coherence tomography angiography
更新于2025-09-23 15:23:52
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Swept source optical coherence tomography analysis of choroidal thickness in macular telangiectasia type 2: a case-control study
摘要： Purpose There has been a recent interest in the association of macular telangiectasia (MacTel) type 2 with central serous choroidopathy and other pachychoroid disorders. This study was performed to assess the subfoveal choroidal thickness (SFCT) in patients with MacTel type 2 and compare it with healthy controls using swept source optical coherence tomography (SS-OCT). Methods It was a retrospective case-control study performed at a tertiary eye care center. The cases constituted patients with MacTel type 2 detected over the last 2 years (April 2016 to March 2018). The controls were healthy adults with no posterior segment pathology. The patients were evaluated with color fundus photography, SS-OCT (Triton, Topcon Inc., Oakland, New Jersey, USA) and fundus fluorescein angiography. The cases were staged based on Gass and Blodi classification. SFCT was compared between the two groups. Results Sixty-five eyes of 33 patients with MacTel were included. The controls consisted of 61 eyes of 33 healthy age-matched (p = 0.81) and sex-matched (p = 0.31) adults. The mean SFCT in cases (353.0 ± 91.2 μm) was higher than controls (289.2 ± 69.0 μm), and this difference was statistically significant (p = 0.0001). The mean SFCT was different in various stages: 346.6 ± 86.3 μm (stage 2), 334.6 ± 90.2 μm (stage 3), 374.6 ± 94.0 μm (stage 4), and 294.8 ± 68.8 μm (stage 5), though this was not statistically significant (p = 0.28). Conclusions The choroid in MacTel type 2 patients was significantly thickened as compared to controls. SFCT may vary as the structural changes worsen over time.
关键词： Macular telangiectasia type 2,Swept source optical coherence tomography,Subfoveal choroidal thickness,Enhanced depth imaging
更新于2025-09-23 15:22:29