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A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging
摘要： Osteosarcoma is the most common primary malignant tumor of bone, particularly among children and adolescents. Advances in imaging, surgical techniques, and implants have dramatically reduced the need for amputation in the past three decades. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) shows impressive advantages of deeper tissue penetration and higher spatial resolution, which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma. To the best of our knowledge, this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.
关键词： NIR-II,orthotopic osteosarcoma,imaging
更新于2025-09-23 15:19:57
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Facile Synthesis of Noncytotoxic PEGylated Dendrimer Encapsulated Silver Sulfide Quantum Dots for NIR-II Biological Imaging
摘要： Near-Infrared-II (NIR-II, 1000-1700 nm) bioimaging features high penetration depth and high spatio-temporal resolution compared to traditional fluorescence imaging, but the key is to develop stable and biocompatible NIR-II fluorophores suitable for in vivo applications. Silver sulfide quantum dots (Ag2S QDs) have been demonstrated excellent for in vivo NIR-II imaging with unique optical properties and decent biocompatibility, but they often require complex post modifications for in vivo applications. Herein we demonstrate a facile one-pot strategy to synthesize the PEGylated dendrimer-encapsulated Ag2S QDs useful for in vivo NIR-II imaging. Silver ions were first loaded into the core of acylthiourea-functionalized dendrimer (PEG-PATU) through the coordination between silver ions and acylthiourea groups, followed by the addition of sodium sulfide to form Ag2S QDs in situ. The resulting PEG-PATU Ag2S QDs hold excellent NIR-II fluorescence signal, and thus could be executed for high efficiency labelling and tracking of A549 cancer cells mobility in vivo and real time visualization of vast circulatory network of a mouse.
关键词： in vivo imaging,PEGylated dendrimer,one-pot synthesis,Ag2S QDs,NIR-II bioimaging
更新于2025-09-23 15:19:57
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Damage-free patterning of thermally sensitive CIGS thin-film solar cells: Can nanosecond pulses outperform ultrashort laser pulses?
摘要： Nanosecond pulses are usually not considered as a suitable candidate for low-damage processing of heat-sensitive materials due to high thermal effects and significant melt formation. Many studies have shown, that CIGS is thermally sensitive material and ultrashort lasers have been chosen as the primary source for the processing of CIGS cells. However, we report on the P3 scribing of CIGS thin-film solar cells with the ns pulse duration at the wavelength of 2.5 μm – a wavelength close to the mid-infrared region and compare the results with the ps pulses covering traditional wavelengths of 355 nm, 532 nm, 1064 nm, and 1342 nm. In our case, 6 ns pulses at 2.5 μm wavelength outperformed the picosecond laser sources operating at VIS and NIR wavelength range. The minimal P3 scribe conductivity of 4.7 mS/m was achieved for ns laser patterning, corresponding to simulated CIGS module efficiency loss of just 0.01%. We proposed that high absorption in the transparent conductive oxide - TCO efficiently shielded the underlying CIGS with only a fraction of energy reaching the back-contact. Finally, results show that nanosecond pulses can be as competitive as picosecond ones for P3 processing of high-efficiency CIGS devices.
关键词： CIGS,Nanosecond laser,Scribing,Picosecond laser,VIS and NIR wavelength range,Thin-film
更新于2025-09-23 15:19:57
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Design of a Broadband NIR Phosphor for Security-Monitoring LEDs: Tunable Photoluminescence Properties and Enhanced Thermal Stability
摘要： Near-infrared (NIR) phosphors with capability for blue light to 850 nm broadband NIR emission conversion are highly desirable for security-monitoring LEDs. Targeted phosphor LaSc2.93-yGayB4O12(LSGB): 0.07Cr3+ (y = 0.6) is designed from the initial model of LaSc2.93B4O12(LSB): 0.07Cr3+ by chemical composition modification. The correlations among crystal-field environment, structural evolution, and luminescence properties of LSGB: 0.07Cr3+ (0 ≤ y ≤ 1.5) are elucidated by the Dq/B values, decay curves, and polyhedron distortion. The substitution of Sc3+ by Ga3+ in LSGB: Cr3+ (0 ≤ y ≤ 1.5) leads to decreasing structural polyhedron distortion and strengthened crystal field, consequently resulting in the blue-shift of broadband emission and enhanced thermal stability of LSGB: 0.07Cr3+ (y = 0.6) compared to that of LSB: 0.07Cr3+. The above results demonstrate that the superiority of blue-shift and enhanced thermal stability of LSGB: 0.07Cr3+ (y = 0.6) make it more suitable for the blue-pumped security-monitoring LEDs.
关键词： luminescence properties,crystal-field environment,security-monitoring LEDs,thermal stability,structural evolution,LaSc2.93-yGayB4O12(LSGB): 0.07Cr3+,Near-infrared (NIR) phosphors
更新于2025-09-23 15:19:57
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Photoconducting Devices with Response in the Visiblea??Near-Infrared Region Based on Neutral Ni Complexes of Aryl-1,2-dithiolene Ligands
摘要： Metal bis(1,2-dithiolene) complexes belonging to the class [Ni(Ar-edt)2]x? [Ar-edt2? = arylethylene-1,2-dithiolate; Ar = phenyl, (1x?), 2-naphthyl (2x?); x = 0 and 1] were fully characterized by NMR, UV?visible?near-infrared (UV?vis?NIR), diffuse reflectance, and FT-IR spectroscopy, as well as cyclic voltammetry and single-crystal X-ray diffraction analysis. These complexes have emerged as new photoconducting materials that allowed for the development of a prototype of photodetectors with response in the vis?NIR region. The photodetecting devices showed in some cases quantum efficiencies orders of magnitude higher than those of previously reported 1,2-dithiolene systems.
关键词： vis?NIR region,photoconducting materials,photodetectors,Metal bis(1,2-dithiolene) complexes,quantum efficiencies
更新于2025-09-23 15:19:57
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Near-Infrared-Detached Adhesion Enabled by Upconverting Nanoparticles
摘要： Achieving efficient and biocompatible detachment between adhered wet materials (i.e., tissues and hydrogels) is a major challenge. Recently, photodetachable topological adhesion has shown great promise as a strategy for conquering this hurdle. However, this photodetachment was triggered by UV light with poor biocompatibility and penetration capacity. This study describes near-infrared (NIR) light-detached topological adhesion based on polyacrylic acid coated upconverting nanoparticles (UCNP@PAA) and a photodetachable adhesive (termed Cell-Fe). Cell-Fe is a coordinated topological adhesive consisting of carboxymethylcellulose and Fe3+ that can be photodecomposed by UV light. To prepare a substrate for NIR-detached topological adhesion, UCNP@PAA and Cell-Fe were mixed and brushed on the surface of the model adherent. The UCNP@PAA can harvest NIR light and convert it into UV light, triggering the decomposition of the Cell-Fe and inducing the detachment. This NIR-detached topological adhesion is also feasible in deep tissue because of the ability of NIR light to penetrate tissue.
关键词： upconverting nanoparticles,NIR-detached adhesion,biocompatibility,deep tissue
更新于2025-09-23 15:19:57
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Ag2S-Glutathione Quantum Dots for NIR Image Guided Photothermal Therapy
摘要： Aqueous synthesis of glutathione (GSH) coated Ag2S quantum dots (QD) with strong emission in the medical imaging window (700-900 nm) were prepared from AgNO3. Variations in temperature, time, pH and sulfur source (Na2S and thioacetamide) were studied to tune the emission wavelength and intensity of QDs. The optimum synthesis condition to produce the smallest QDs (ca 7 nm) with the highest quantum yield (70 %) and excellent stability was determined as 50 ℃ and pH 10 where Na2S was used in 2 h reactions. Cytotoxicity was evaluated with MTT assay on HT29 and MCF7 cancer cell lines and indicated no significant toxicity of QDs up to 200 μg/mL. Photothermal Therapy (PTT) potential was first investigated by 795 nm, continuous-wave fiber coupled diode laser using aqueous solutions of QDs and then on HT29 and MCF7 cells. QD (150 μg/mL) treated MCF7 cells almost quantitatively died after 10 min irradiation at 795 nm (700 mW, 1.82 W/cm2) and the viability of HT29 cells dropped to 40%. Most cell death was late apoptotic/necrotic. This study indicates that such laser irradiation procedure and the QDs are safe yet, their combination provides a dramatic cell death upon short laser treatment. PTT coupled with strong intracellular optical signal promotes Ag2S-GSH QDs as potential theranostic nanoparticles.
关键词： glutathione coating,NIR imaging,Ag2S quantum dots,theranostic nanoparticles,photothermal therapy
更新于2025-09-23 15:19:57
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Inkless Multi-Color Writing and Copying of Laser-Programmable Photonic Crystals
摘要： Rewritable papers, as an environmentally friendly alternative for information delivery, hold great promise to reduce the abundant uses of ordinary papers that cause severe environmental problems. In recent decades, photonic crystals (PCs) have shown great potential in developing rewritable papers. However, existing PC papers still confront many challenges, including poor storage stability, short-cycle lifetime, monotonous colors, and absence of copying capability. Herein, we report the fabrication of a rewritable PC paper based on programmable configurations of a synthesized shape memory polymer (SMP). The resulting SMP-based PC paper does not need additional inks and can be facilely written by near infrared (NIR) light with assistance from a pre-printed black paper as a photothermal layer. Heating from the black paper induces various stable configurations of the PCs, thus creating multiple colors in the irradiated areas. Moreover, the PC paper possesses excellent colorful copying capability that can transform information from a paper with pre-printed black letters or complex images via scanning with NIR light. These images can be stably stored for more than 6 months at ambient conditions, which can be even erased and rewritten over 50 times without significant loss in color quality. This environment-friendly SMP-based PC paper with extraordinary properties holds great promise in the fields of next-generation office papers, smart price tags, and anti-counterfeiting labels.
关键词： NIR light,copying capability,multi-color writing,rewritable papers,photonic crystals,shape memory polymer
更新于2025-09-23 15:19:57
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A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms
摘要： Background: Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest. Results: In this study, we developed a multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT and NO release for synergistic therapy against MDR Gram-negative bacteria and their biofilms. When located at the infected sites, TG-NO-B was able to selectively bind to the surfaces of Gram-negative bacterial cells and their biofilm matrix through covalent coupling between the BA groups of TG-NO-B and the bacterial LPS units, which could greatly improve the antibacterial efficiency, and reduce side damages to ambient normal tissues. Upon single NIR laser irradiation, TG-NO-B could generate hyperthermia and simultaneously release NO, which would synergistically disrupt bacterial cell membrane, further cause leakage and damage of intracellular components, and finally induce bacteria death. On one hand, the combination of NO and PTT could largely improve the antibacterial efficiency. On the other hand, the bacterial cell membrane damage could improve the permeability and sensitivity to heat, decrease the photothermal temperature and avoid damages caused by high temperature. Moreover, TG-NO-B could be effectively utilized for synergistic therapy against the in vivo infections of MDR Gram-negative bacteria and their biofilms and accelerate wound healing as well as exhibit excellent biocompatibility both in vitro and in vivo. Conclusions: Our study demonstrates that TG-NO-B can be considered as a promising alternative for treating infections caused by MDR Gram-negative bacteria and their biofilms.
关键词： Biofilms,Single-NIR-laser-triggered,Graphene,NO release,Multidrug-resistant Gram-negative bacteria,Synergistic,Photothermal
更新于2025-09-23 15:19:57
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Spectroscopic Characterization of Emulsions Generated with a New Laser-Assisted Device
摘要： This paper presents a spectroscopic study of emulsions generated with a laser-assisted device. Fourier transform infrared (FTIR), Raman and UV–Vis–NIR reflectance spectra of emulsions, recorded before and after exposure to laser radiation were used to characterize the effect of laser irradiation. The paper also presents a comparison between the calculated IR spectra and the experimental FTIR spectra of an emulsion’s components. FTIR measurements allowed the identification of absorption bands specific to each of the emulsions’ components. Moreover, it enabled the observation of destabilization of the emulsion in real-time. Raman spectroscopy allowed the observation of the modifications at a molecular level, by identifying the vibrations of the representative functional groups and the polymerization of sodium tetradecyl sulfate (STS) molecules by analyzing the evolution of the carbonyl band. UV–Vis–NIR reflectance spectra of emulsions before and after exposure to laser radiation showed that the physical characteristics of the emulsions changed during irradiation—the dimensions of the droplets decreased, leading to an emulsion with a better time stability. These results proved that the employed spectroscopy techniques were powerful tools in emulsion analysis.
关键词： UV–Vis–NIR reflectance spectroscopy,FTIR spectroscopy,emulsion,Raman spectroscopy
更新于2025-09-23 15:19:57