- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Aloe-Emodin/Carbon Nanoparticles Hybrid Gels with Light-Induced and Long-Term Antibacterial Activity
摘要： Development of effective antimicrobial wound dressings has drawn wide attention in the wound care market. Here, we synthesized a natural antibiotic (aloe-emodin, AE) and carbon nanoparticles co-embedded polymer hybrid hydrogel as a novel wound dressing in the fight against skin infections potently. We systematically evaluated the properties of the obtained hydrogels, including physic-chemical characteristics, photothermal conversion efficiency, reactive oxygen species (ROS) generation, AE-released profile, antibacterial activity and wound-healing capability. The hybrid gels can initially deduct the number of bacteria rapidly in a short time through the near-infrared-light (NIR)-triggered photothermal/ROS route, and continuously kill the remaining live cells by released-AE from gels after turning off NIR source with the long-term antibacterial effect. These two antibacterial manners that complement each other lead to the excellent antibacterial performances towards various bacterial strains including multidrug-resistant bacteria. Moreover, in vivo Staphylcoccus aureus-infected animal experiments indicate that the hybrid gels upon NIR irradiation have a striking ability towards wound infection. These studies demonstrate that the AE and carbon nanoparticles co-embedded hybrid polymer hydrogels with NIR exposure may have applications in the wound combined care for bacterial infections.
关键词： NIR irradiation,aloe-emodin,wound dressing,ROS,carbon nanoparticles,antibacterial hydrogel
更新于2025-09-23 15:21:21
-
Polymeric Microneedles Integrated with Metformin-Loaded and PDA/LA-Coated Hollow Mesoporous SiO2 for NIR-triggered Transdermal Delivery on Diabetic Rats
摘要： Herein, a NIR-responsive polymeric microneedles (MNs) system incorporated with metformin-loaded and polydopamine/lauric acid (PDA/LA)-coated hollow mesoporous SiO2 have been developed for transdermal delivery of antidiabetic drug (metformin). Firstly, an anti-diabetic drug was firstly loaded within hollow mesoporous SiO2 nanoparticles (HMSN) by a diffusion method. Then, PDA as photothermal conversion agent and lauric acid (LA) as phase change material (PCM) were coated onto the HMSN to form NIR-responsive drug nanocarriers. Finally, these metformin-Loaded and PDA/LA-coated HMSN were encapsulated into poly(vinylpyrrolidone) (PVP) MNs. After insertion into skin tissue, LA could be melt with the photothermal conversion of PDA under NIR-light, and thus enabling to release encapsulated metformin from MNs. The in vivo release behavior of metformin from MNs into skin was further studied to investigate its hypoglycemic effect on diabetic rats. Compared with the subcutaneous injection of metformin, the bioavailability of MNs-NIR groups was 95.8±2.7%. The antidiabetic drug can be precisely released by adjustment of exposure time and power densities of NIR-light.
关键词： NIR irradiation,microneedles,transdermal delivery,diabetes,hypoglycemic
更新于2025-09-10 09:29:36