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The diagnosis of nasopharyngeal carcinoma by optical coherence tomography (OCT)
摘要： We have attempted to explore the intrinsic differences in the optical properties of the nasopharyngeal carcinoma (NPC) and normal tissue by optical coherence tomography (OCT). OCT imaging of normal tissue provided three layers of epithelium, lamina propria, and the brighter interface of basement membrane; while carcinomas disrupted the layered construction embedded in signal-poor images. The morphologies were consistent with histological findings. Sensitivity and specificity were 90% and 100%, respectively. This pilot study demonstrates that NPC could be diagnosed by visualization, which implies that OCT might be potentially used to differentiate normal from NPC tissue in the early stage as an invasive biopsy.
关键词： morphology,NPC,OCT,early diagnosis
更新于2025-09-09 09:28:46
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Diagnostic Performance of Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Glaucoma in an Elderly Population: The ALIENOR Study
摘要： PURPOSE. To assess diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) to discriminate glaucoma and control subjects in an elderly population. METHODS. The antioxidants, essential lipids, nutrition and ocular maladies study (ALIENOR: ‘‘Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires’’) is a population-based study. From 2009 to 2010, a total of 624 subjects, aged 74 years or older underwent a complete eye examination, including optic disc color photography and SD-OCT examination of the macula and the optic nerve head. Glaucoma diagnosis was made using retinophotography of the optic nerve head and International Society for Epidemiologic and Geographical Ophthalmology criteria. Average and sectorial peripapillary retinal nerve ?ber layer thicknesses (RNFLT) were compared between glaucoma and control subjects using area under the receiver operating characteristic curves (AUC), positive and negative likelihood ratios (LRt/LR(cid:2)), and diagnostic odds ratios (DOR). RESULTS. A total of 532 subjects had complete data, 492 were classi?ed as controls and 40 were classi?ed as glaucoma. Mean age was 82.1 6 4.2 years and average RNFLT was signi?cantly different between both groups (controls: 88.7 6 12.2 lm, glaucoma: 65.4 6 14.4 lm, P < 0.001). Highest AUC values were observed for average (0.895), temporal-inferior (0.874), and temporal-superior (0.868) RNFLT. Temporal-superior RNFLT had the highest DOR (25.31; LRt, 4.65; LR(cid:2), 0.18), followed by average RNFLT (DOR: 24.80; LRt, 6.36; LR(cid:2), 0.26). When using the normative database provided by the machine, DOR increased to 31.03 (LRt, 1.75; LR(cid:2), 0.06) if at least one parameter was considered abnormal (at P < 0.05). CONCLUSIONS. Parameters of SD-OCT RNFL may provide valuable information in a screening strategy to improve glaucoma detection in a general population of elderly people.
关键词： spectral-domain OCT,OCT,optical coherence tomography,glaucoma screening,likelihood ratios,aging
更新于2025-09-04 15:30:14
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Changes by Optical Coherence Tomography after Ocular Miniaturization of the Cornea Using Artificial Tears in a Spanish Population
摘要： Purpose: The aim of this study was to evaluate the efficacy of three different artificial tears (0.4% hyaluronic acid, a combination of polyethylene glycol 400 4 mg/ml-Propylene glycol 3 mg/ml, and the combination of 5 mg/ml of sodium carboxymethyl cellulose and glycerin) to increase the corneal OCT pachymetry in a group of patients. Material and methods: 53 patients admitted to the Ophthalmology Unit in Hospital San Juan de Dios, Tenerife, Canary Islands, Spain were analyzed by corneal OCT and the obtained data were compared before and after application of artificial tears. The pachymetry was compared with the instillation of sodium fluorescein and hydrochloride oxybuprocaine prior to the use of the tear and after application of tears. Results: We observed that pachymetry increased after application of the three different artificial tears mentioned above. No significant differences were observed when the efficacy of the three different artificial tears preparations was compared after statistical analysis. Conclusions: In this study, the efficacy of the artificial tears to raise pachymetry was demonstrated and also this increase was mainly dependent on the corneal epithelium layer in the patients included in this study.
关键词： Artificial,Changes,Tears,OCT
更新于2025-09-04 15:30:14
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Current OCT Approaches Do Not Reliably Identify TCFAs
摘要： It is now clearly established that Thin-Capped Fibroatheromas (TCFAs) lead to most Acute Coronary Syndromes (ACSs). The ability to selectively intervene on TCFAs predisposed to rupture and ACSs would dramatically alter the practice of cardiology. While the ability of OCT to identify thin walled plaques at micron scale resolutions has represented a major advance, it is a misconception that it can reliably identify TCFAs. One major reason is that the ‘diffuse border’ criteria currently used to determine ‘lipid plaque’ is almost undoubtedly from high scattering in the intima and not because of core composition (necrotic core). A second reason is that, rather than looking at lipid collections, studies need to be focused on identifying necrotic cores with OCT. Necrotic cores are characteristic of TCFAs and not lipid collections. Numerous other OCT approaches are available which can potentially accurately assess TCFAs, but these have not been aggressively pursed which we believe likely stems in part from the misconceptions over the efficacy of ‘diffuse borders’.
关键词： Myocardial infarction,Optical coherence tomography: OCT,Macrophages,Plaque rupture,Acute coronary syndrome: ACS,Thin capped fibroatheroma: TCFA,Lipid,Massachusetts General Hospital Lightlab
更新于2025-09-04 15:30:14
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In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography
摘要： This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (lCT). Only intravascular ultrasound imaging (IVUS) vs. optical coherent tomography (OCT) were looked at, as they fulfilled the criteria for integration in the needle design. An in-vitro study was conducted on six human cadaveric tali that were dissected and submerged in saline. To simulate the natural appearance of cartilage defects, three types of defects were created via a standardised protocol: osteochondral defects (OCD), chondral defects (CD) and cartilage surface fibrillation (CSF), all sized between 0.1 and 3 mm in diameter. The detection rate by two observers for all diameters of OCD were 80, 92 and 100% with IVUS, OCT and lCT, for CD these were 60, 83 and 97%, and for CSF 0, 29 and 24%. Both IVUS and OCT can detect the presence of OCD and CD accurately if they are larger than 2 mm in diameter, and OCT can detect fibrillated cartilage defects larger than 3 mm in diameter. A significant difference between OCT–lCT and IVUS–lCT was found for the diameter error (p = 0.004) and insertion depth error (p = 0.002), indicating that OCT gives values closer to reference lCT. The OCT imaging technique is more sensitive to various types and sizes of defects and has a smaller diameter, and is therefore preferred for the intended application.
关键词： (Osteo)chondral defects,Catheter imaging,Needle intervention,OCT,IVUS,Orthopedics
更新于2025-09-04 15:30:14
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Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy
摘要： Reproducible skills are essential for successful induction of a rat model of anterior ischemic optic neuropathy (rAION). We established an in vivo validation index by measuring the natural course of optic nerve head (ONH) width and retinal nerve fiber layer (RNFL) thickness in the rAION model using optical coherence tomography (OCT). The rAION model was induced by photodynamic operations. We measured the ONH width and RNFL thickness in the acute stage (<3 days), subacute stage (day 7 and day 14) and later stage (day 28) post-infarct by OCT. RNFL were measured by hematoxylin and eosin stain (HE) to confirm the OCT findings. The RGCs survival rate was determined by retrograde Fluoro-gold labeling, and the visual function was assessed with flash visual-evoked potentials (FVEPs) 4 weeks post-infarct. The ONH showed significant swelling in the acute stage, which also correlated with RNFL swelling. The swelling was reduced to normal within one-week post-infarct. The rAION group (0.51± 0.12 mm2) showed a significant RNFL thinning when compared with sham groups (0.92±0.15 mm2, p<0.05) on day-28 post-infarct. And HE-stained retina cross sections also showed RNFL thinning, which further confirmed our OCT Findings. The RGC density and P1-N2 amplitude were significantly reduced in rAION. Swelling, reduction of swelling, and atrophy of RNFL in acute, sub-acute, and later stage, respectively, are important events for confirming the successful induction of rAION. They suggest that the longitudinal OCT data provides a reliable index for validating the reproducibility and correct order of rAION.
关键词： optic nerve head (ONH),retinal ganglion cells (RGCs),optical coherence tomography (OCT),anterior ischemic optic neuropathy in rats (rAION),retina nerve fiber layer (RNFL)
更新于2025-09-04 15:30:14
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Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy
摘要： Optical coherence tomography reveals retinal ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thinning in chronic optic nerve injury. With acute optic nerve injury, as in acute nonarteritic anterior ischemic optic neuropathy (NAION), swelling obscures early demonstration of RNFL thinning, which might be used to evaluate therapies. We hypothesized that measurement of GCL plus inner plexiform layer (IPL) thickness and trajectory of thinning would show it is an earlier and more accurate biomarker of early permanent neuronal injury.
关键词： OCT,retinal ganglion cell layer,non-arteritic anterior ischemic optic neuropathy
更新于2025-09-04 15:30:14
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Retinal and Choroidal Imaging With 870-nm Spectral-Domain OCT Compared With 1050-nm Spectral-Domain OCT, With and Without Enhanced Depth Imaging
摘要： The purpose of this study was to compare images of the retina and choroid obtained with Spectralis 1050-nm spectral-domain optical coherence tomography (SD-OCT) with and without enhanced depth imaging (EDI) to the commercially available 870-nm SD-OCT with and without EDI. Methods: Full-length 308 line scans were obtained with both 870- and 1050-nm Spectralis OCT instruments, with and without EDI. Two trained retina physicians masked to wavelength and EDI status assessed the ability to visualize the vitreoretinal interface and full-thickness choroid, and subfoveal choroidal thickness (SFCT) was measured. Results: Included in the study were 21 eyes. The vitreoretinal interface was visualized best with 870-nm OCT without EDI and was diminished with 1050-nm OCT. Graders preferred 1050 nm with EDI over 870 nm with EDI in qualitative comparisons of the choroid; 1050 nm without EDI was slightly preferred over 870 nm with EDI but was not statistically significant. SFCT measurements correlated well among the imaging modalities except for 870 nm without EDI. Conclusions: SD-OCT with EDI at 870 nm provides good visualization of both the vitreoretinal interface and choroid, whereas 1050-nm SD-OCT with or without EDI provides more choroidal detail at the expense of visualization of the vitreoretinal interface.
关键词： longer wavelength,optical coherence tomography (OCT),choroid,retina
更新于2025-09-04 15:30:14
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Hornhautdystrophien in der optischen Koh?renztomographie; Corneal dystrophies in optical coherence tomography;
摘要： Hintergrund. Die korneale optische Koh?renztomographie (Anterior-Segment-OCT, AS-OCT) wird in der aktuellen IC3D-Klassifikation von Hornhautdystrophien als Methode zur Verbesserung der klinischen Diagnosefindung und Behandlung beschrieben. Fragestellung. In dieser Fallserie sollen AS-OCT-Bilder von Hornhautdystrophien auf hornhautmorphologische Ver?nderungen analysiert werden. Material und Methoden. Es handelt sich um eine retrospektive, bildmorphologische Fallserie mit 38 Augen. Die AS-OCT-Bilder wurden mit dem hochaufl?senden Zeiss Cirrus 5000-OCT (Oberkochen, Deutschland) aufgenommen. Folgende Hornhautdystrophien wurden analysiert: epitheliale Basalmembrandystrophie, Meesmann-Hornhautdystrophie, Reis-Bücklers-Hornhautdystrophie, granul?re Hornhautdystrophie Typ 1, granul?re Hornhautdystrophie Typ 2 und die makul?re Hornhautdystrophie. Ergebnisse. Die AS-OCT-Bilder zeigen deutlich die typischen Ver?nderungen der einzelnen Hornhautdystrophien durch Hyper- und Hyporeflektivit?ten in den einzelnen Hornhautschichten. Die Befunde in den AS-OCT-Bildern korrelieren gut mit den in der Literatur bereits vorhandenen, histologischen Beschreibungen und liefern zus?tzliche Informationen zur Spaltlampenuntersuchung, v. a. hinsichtlich der exakten Lokalisation der Ver?nderungen. Diskussion. Die AS-OCT-Bildgebung scheint ein hilfreiches Instrument zur Bestimmung morphologischer Ver?nderungen bei Patienten mit Hornhautdystrophien zu sein und k?nnte sowohl die Diagnosestellung als auch die chirurgische Therapieentscheidung erleichtern.
关键词： Hornhauttrübung,Optische Koh?renztomographie,OCT,Hornhautdystrophie,Dystrophie
更新于2025-09-04 15:30:14
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Optical coherence tomography imaging of the basal ganglia: feasibility and brief review
摘要： Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonfly, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intra-cerebral OCT feasibility on brain mapping during neurosurgical procedures.
关键词： Basal ganglia,Optical coherence tomography (OCT),Rat brain,Histology,Thalamus,Brain imaging
更新于2025-09-04 15:30:14