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Facile green synthesis of organosilica nanoparticles by a generic “salt route”
摘要： Colloidal silica has wide applications and the global demand of specialty silica is continually increasing. Therefore, it is significant to develop a synthetic method that is simple, versatile, energy-saving, ecologically benign, and easily scalable. Biomimetic synthesis of colloidal silica represents a promising strategy; however, it often requires the synthesis or extraction of specialized macromolecules. In this paper, we present a novel aqueous, one-pot, and green route for synthesis of organosilica nanoparticles. The reaction systems contain only water, an organosilane precursor, a salt, and a commonly used surfactant or amphiphilic polymer. The reaction was performed at ambient conditions without adding any additional solvent, energy, and harsh chemicals. The key findings include the novel identification of 5 salts (i.e. nitrite, fluoride, dibasic phosphate, acetate, and sulfite) that can catalyze organosilica condensation and the resulting formation of nano-colloids. Moreover, the presence of amphiphilic molecules is essential for salt catalysis at low salt concentrations and at nearly neutral pH. Solid-state NMR and in-situ ATR-FTIR studies confirmed that organosilica condensation is highly efficient under the mild reaction condition. In conclusion, the present study demonstrates that "soft" interaction between salts and surfactants (or polymers) can be utilized to construct an effective platform for synthesis of "hard" organosilica particles. The proposed method is generic and applicable to a wide range of commonly used surfactants (viz. non-ionic, anionic, cationic) and amphiphilic polymers, as well as to organosilanes with various hydrophobic functional groups (e.g. mercaptopropyl, vinyl, and methyl).
关键词： Salts,Microreactors,Surfactants,Organosilica nanoparticles,Biomimetic synthesis,Colloids
更新于2025-09-23 15:22:29
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Double protected lanthanide fluorescence core@shell colloidal hybrid for the selective and sensitive detection of ClO-
摘要： Without any surfactant or organic solvent, a water-borne method incorporated a biphasic sol-gel process and a Pickering emulsion process was firstly applied to encapsulate lanthanide complexes. Compared with the free one, the achieved double protected lanthanide fluorescence colloidal hybrid particles with core@shells structure has a specific ClO- detection with high selectivity and sensitivity in contrast with other inorganic ions including Cu2+, Fe3+ and other strong acids. With strong oxidation characteristics, ClO- can gradually penetrate through silica shell, and quench the red fluorescence of lanthanide ions in the organosilica core. This core@shell colloidal nanoprobe exhibits an excellent sensing capacity for hypochlorite in real sample. This green environment friendly method could be easily extended to form functional hybrid particles with other types of reactive oils and nanoparticles for devising other specified fluorescent sensors.
关键词： Core@shell,Hypochlorite,Organosilica,Fluorescence,Pickering emulsion
更新于2025-09-11 14:15:04
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Chemodrug-Gated Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Multimodal Imaging-Guided Low-Temperature Photothermal Therapy/Chemotherapy of Cancer
摘要： Non-invasive physical treatment with relatively low intensity stimulation and the development of highly efficient anticancer medical strategy are still desirable for cancer therapy. Herein, a versatile biodegradable hollow mesoporous organosilica nanocapsule (HMONs) nananoplatform that is capped by the gemcitabine (Gem) molecule through a pH-sensitive acetal covalent bond is designed. The fabricated nanocapsule exhibits desirable small molecule release at the tumor tissues/cell sites, shows a reduced potential for drug accumulation risk. After loading indocyanine green (ICG), the heat-shock protein 90 (Hsp 90) inhibitor, 17AAG and modification with polyethylene glycol (NH2-PEG), the resulting ICG-17AAG@HMONs-Gem-PEG exhibited a precisely controlled release of ICG and 17AAG and low-temperature photothermal therapy (PTT) (~41 °C) with excellent tumor destruction efficacy. In addition, ICG loaded conferring the nanoplatform with near-infrared fluorescence imaging (FL) and photoaccoustic (PA) imaging capability. In short, this work not only presents a smart drug self-controlled nanoplatform with pH-responsive payloads released and theranostic performance, but also provides an outstanding low-temperature PTT strategy, which is highly valid in inhibition of cancer cells with minimal damage to the organism. Therefore, this research provides a paradigm that has a chemodrug-gated HMONs-based theranostic nanoplatform with intrinsic biodegradability, multimodal imaging capacity, high low-temperature PTT/chemotherapy efficacy and reduced systemic toxicity.
关键词： biodegradability,nanotheranostics,Hollow mesoporous organosilica,chemodrug gatekeeper,low-temperature photothermal therapy
更新于2025-09-11 14:15:04
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Sensitive, Real-Time and In-Vivo Oxygen Monitoring for Photodynamic Therapy by Multifunctional Mesoporous Nanosensors
摘要： Real-time monitoring of oxygen consumption is beneficial to predict treatment response and optimize therapeutic protocols for photodynamic therapy (PDT). In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2). This nanoprobe shows significantly improved biocompatibility and high cellular uptake. In-vitro eperiments demonstrate that the HMON-[(Ru(dpp)3)]Cl2 can sensitively detect oxygen changes between 1 %-20 %. On this basis, photosensitizer chlorin e6 (Ce6) and [(Ru(dpp)3)]Cl2 are simultaneously loaded in the HOMNs (denoted as HMON-Ce6-[(Ru(dpp)3)]Cl2) for real-time oxygen monitoring during photodynamic therapy. The HMON-Ce6-[(Ru(dpp)3)]Cl2 can reflects oxygen consumption in solution and cells in photodynamic therapy. Furthermore, the ability of HMON-Ce6-[(Ru(dpp)3)]Cl2 nanosensor to monitor oxygen changes is demonstrated in tumor-bearing nude mice.
关键词： oxygen detection,mesoporous organosilica,photodynamic therapy,in-vivo,real-time
更新于2025-09-04 15:30:14