- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Insight into the mechanisms of type III minocycline-induced pigmentation removal: A case of repeated immediate pigment clearing with the Q-switched 755-nm alexandrite laser over a 13-year period
摘要： A 68-year-old man with rheumatoid arthritis presented for laser treatment of facial pigmentation. He had taken oral minocycline 100 mg 3 times weekly for 8 years (cumulative dose, 124.8 g) because of severe arthritic discomfort. Physical examination showed patchy slate blue/grey hyperpigmentation of the face, gums, teeth, and nail beds, consistent with type III minocycline-induced pigmentation (MP). Two different laser modalities were tested before treatment: Q-switched 755 nm (Qs755nm) alexandrite and Q-switched 1064 nm (Qs1064nm) neodymium:YAG. Qs755nm at 2.0 Hz/4-mm spot/3.4 J/cm2 showed the most improvement, with immediate pigment clearing, and was used for full facial treatment (3450 pulses). Pigment resolution was maintained at 13 months despite continued minocycline use, and the patient was highly satisfied. The patient continued taking minocycline and re-presented 3 times over the next 13 years with facial hyperpigmentation. Each time, immediate pigment clearing was achieved with the Qs755nm alexandrite laser. Histopathology showed intracellular and extracellular type III MP in the dermis, with notably no detectable change in the posttreatment biopsy. However, the extracellular pigment in the posttreatment sample was no longer highlighted by Fontana-Masson (FM) stain, but intracellular pigment continued to stain with FM. The change in melanin staining is consistent with the clinically observed reduction in pigment intensity.
关键词： immediate pigment lightening,minocycline-induced pigmentation,Q-switched alexandrite laser
更新于2025-09-19 17:13:59
-
[IEEE 2019 IEEE Globecom Workshops (GC Wkshps) - Waikoloa, HI, USA (2019.12.9-2019.12.13)] 2019 IEEE Globecom Workshops (GC Wkshps) - Improving QKD for Entangled States with Low Squeezing via Non-Gaussian Operations
摘要： This study investigates standard and regional algal pigment index 1 (API1) estimates in the Atlantic off the southwestern Iberian Peninsula. Standard API1 data are those delivered by the Medium Resolution Imaging Spectrometer (MERIS) orbiting sensor. Equivalent quantities are computed by applying a regional inversion scheme using as input both MERIS and in situ remote sensing re?ectances (Rrs). Reference data for the development of the regional algorithm and for the analysis of tested products include ?eld measurements of total concentration of chlorophyll a (TChla) and coincident Rrs values collected at different distances from the coast. Validation results, based on matchup analysis, identi?es a systematic overestimation of standard API1 versus the reference TChla values. The additional comparison of product maps in selected regions of interest con?rms this tendency and demonstrates the feasibility and relevance of using regional algorithms for investigating spaceborne products. Analogous applications are hence devised for the early-stage evaluation of the forthcoming Sentinel-3/OLCI data products.
关键词： remote sensing re?ectance,Medium Resolution Imaging Spectrometer (MERIS) algal pigment index 1 (API1),ocean color,multilayer perceptron (MLP) neural nets
更新于2025-09-19 17:13:59
-
Investigation of polymera??based composites by laser desorption ionization Study of their photoa??oxidative aging
摘要： RATIONALE The polybutadiene (PB) is one of the most widely used polymers. Its aging occurs by reaction with oxygen under illumination and may modify its mechanical and/or aesthetic properties. To modify its properties, organic and/or inorganic compounds are generally added to the PB. The aging of such composite materials is poorly known. METHODS The PB and its mixtures with TiO2 and/or the Orange 13 pigment are subjected to an accelerated photo-oxidative aging step for one week. The analysis of PB and its composites with regard to their composition and the aging time, is carried out by 266 nm and/or 355 nm laser/desorption ionization Fourier transform ion cyclotron resonance mass spectrometry (LDI FT ICR–MS). RESULTS Both PB and its degradation products are detected by (+) LDI FT–ICR MS. The oxidation mechanism of the PB is not significantly affected by the used organic or inorganic fillers, which results from the cleavage of the polymer chain and the formation of carbonyl compounds. The crosslinking of the PB is significantly reduced by the two investigated fillers. The (–) LDI FT–ICR MS ensure the specific detection of the Orange 13 pigment. CONCLUSIONS LDI FT ICR - MS has demonstrated its ability to provide relevant information on the degradation of polymer-based composites. The main advantages of this approach are its ability to probe the surface, which is specifically affected by photo-oxidation aging processes, and to access the insoluble degradation compounds.
关键词： Orange 13 pigment,titanium dioxide,photo-aging,Polybutadiene
更新于2025-09-19 17:13:59
-
Ultra-Thick Organic Pigment Layer Up to 10 ??m Activated by Crystallization in Organic Photovoltaic Cells
摘要： Organic optoelectronic devices tend to have limited thickness. Organic light emitting diodes (OLED) and organic photovoltaic cells (OPV) made of organic pigments are typically with thickness of a few or a few tens of nanometers. Thickness of organic photovoltaic cells made with polymers exceeds them typically up to the order of a few 100 nm but still necessarily co-optimized with respect to light absorption and charge transport. Here, we demonstrate that crystallization made a 10-μm-thick pigment layer active in a photovoltaic cell, using a prototypical pair of pigments, phthalocyanine, and fullerene. It is proved that crystalline pigment layer with a thickness much greater than what is needed for optical optimization can be utilized for organic optoelectronic devices and that organic optoelectronic devices have potentiality to relief their design from co-optimization of optics and charge transport.
关键词： bulk hetero-junction,organic electronics,crystallization,organic photovoltaics,pigment,solar cell
更新于2025-09-19 17:13:59
-
Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation
摘要： Purpose: To investigate the change in fluorescence lifetime of retinal pigment epithelium (RPE) after laser irradiation by using an organ culture model. Methods: Porcine RPE-choroid-sclera explants were irradiated with selective retina treatment laser (wavelength: 527 nm, beam diameter: 200 lm, energy: 80–150 lJ). At 24 and 72 hours after irradiation, the mean fluorescence lifetime (sm) was measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) (excitation wavelength: 473 nm, emission: short spectral channel: 498-560 nm, long spectral channel: 560–720 nm). For every laser spot, central damaged zone (zone 1: 120 3 120 lm), area including wound rim (280 3 280 lm except zone 1), and environmental zone (440 3 440 lm except zone 1 and 2) were analyzed. Peripheral zone at a distance from laser spots longer than 2000 lm was examined for comparison. Cell viability was evaluated with calcein-acetoxymethyl ester and morphology with fluorescence microscopy for filamentous-actin. Results: The RPE defect after selective retina treatment was mostly closed within 72 hours. FLIO clearly demarcated the irradiated region, with prolonged sm at the center of the defect decreasing with eccentricity. In short spectral channel, but not in long spectral channel, sm in the environmental zone after 72 hours was still significantly longer than in the peripheral zone. Conclusions: FLIO may clearly demarcate the RPE defect, demonstrate its closure, and, moreover, indicate the induced metabolic changes of surrounding cells during wound healing. Translational Relevance: This ex vivo study showed that FLIO may be used to evaluate the extent and quality of restoration of the damaged RPE and to detect its metabolic change in human fundus noninvasively.
关键词： selective retina therapy,retinal pigment epithelium,fluorescence lifetime,energy metabolism,wound healing
更新于2025-09-16 10:30:52
-
Display Technology 2019: Never a Dull Moment
摘要： This study investigates standard and regional algal pigment index 1 (API1) estimates in the Atlantic off the southwestern Iberian Peninsula. Standard API1 data are those delivered by the Medium Resolution Imaging Spectrometer (MERIS) orbiting sensor. Equivalent quantities are computed by applying a regional inversion scheme using as input both MERIS and in situ remote sensing re?ectances (Rrs). Reference data for the development of the regional algorithm and for the analysis of tested products include ?eld measurements of total concentration of chlorophyll a (TChla) and coincident Rrs values collected at different distances from the coast. Validation results, based on matchup analysis, identifies a systematic overestimation of standard API1 versus the reference TChla values. The additional comparison of product maps in selected regions of interest confirms this tendency and demonstrates the feasibility and relevance of using regional algorithms for investigating spaceborne products. Analogous applications are hence devised for the early-stage evaluation of the forthcoming Sentinel-3/OLCI data products.
关键词： ocean color,remote sensing re?ectance,Medium Resolution Imaging Spectrometer (MERIS) algal pigment index 1 (API1),multilayer perceptron (MLP) neural nets
更新于2025-09-16 10:30:52
-
Evaluation of Retinal Pigment Epithelium and Choroidal Neovascularization in Rats Using Laser-Scanning Optical-Resolution Photoacoustic Microscopy
摘要： Purpose: To demonstrate the value of the laser-scanning optical-resolution (LSOR)-photoacoustic (PA) microscopy (PAM) system and the conventional multimodal imaging techniques in the evaluation of laser-induced retinal injury and choroidal neovascularization (CNV) in rats. Methods: Different degrees of retinal injury were induced using laser photocoagulation. We compared the LSOR-PAM system with conventional imaging techniques in evaluating retinal injury with or without CNV. Six additional rats, treated with an anti-VEGF antibody or immunoglobulin G immediately after photocoagulation, were imaged 7 and 14 days after injection, and CNV lesion areas were compared. Results: In the retinal injury model, fundus autofluorescence showed well-defined hyperreflection, while the lesion displayed abundant PA signals demonstrating nonuniform melanin distribution in retinal pigment epithelium (RPE). RPE was detected with higher contrast in the PAM B-scan image than optical coherence tomography (OCT). Additionally, the CNV lesion was present with multiple PA signal intensi- ties which distinctly characterized the location and area of CNV as found in fundus fluorescein angiography. Further- more, the decreased PA signals extending from the CNV le- sion were similar to those of the vascular bud in ex vivo im- aging, which was invisible in other in vivo images. When treated with anti-VEGF agents, statistically significant differ- ences can be demonstrated by PAM similar to other mo- dalities. Conclusions: LSOR-PAM can detect the melanin distribution of RPE in laser-induced retinal injury and CNV in rats. PAM imaging provides a potential new tool to evalu- ate the vitality and functionality of RPE in vivo as well as to monitor the development and treatment of CNV.
关键词： Age-related macular degeneration,Retinal pigment epithelium,Multimodal imaging,Photoacoustic microscopy,Choroidal neovascularization
更新于2025-09-12 10:27:22
-
New process of tempering color printed glass by using laser irradiation
摘要： Colored glass products with various printing technologies are becoming more important in industry. The aim is to achieve individual solution in a very short delivery time. Conventional thermal treatment of burning glasses in oven for tempered color printing has predominant issues with high time consumption, energy consumption and manufacturing cost. It requires alternative process development. This paper proposes laser process to overcome issues in conventional treatment with the latest results of tempering colored glass. Samples have been analyzed with the scanning electron microscope (SEM). Two different laser systems have been applied and the glass has been printed with black paste.
关键词： scanning electron microscope (SEM),glass,printing technologies,laser material processing,pigment paste,surface treatment
更新于2025-09-12 10:27:22
-
Treatment of gingival pigmentation with a 755-nm alexandrite picosecond laser
摘要： Hyperpigmentation of the gums can be associated to several etiological factors. Although it is physiological in most cases it can cause esthetic concerns in some patients. The objective of our study was to evaluate the clinical efficacy and patient satisfaction with the treatment of gingival hyperpigmentation with picosecond alexandrite laser of 755 nm. We selected two patients with gingival hyperpigmentation on the anterior face of the upper and lower gums of years of evolution. Malignancy, drug ingestion, exposure to tobacco and underlying genetic and endocrine alterations were ruled out. Clinical photographs were taken before treatment and 2 weeks after the procedure. In both cases, anterior gingival areas were depigmented with satisfaction. The patients did not complain of severe pain or discomfort. Two weeks after the procedure the gingiva showed almost complete depigmentation. In conclusion, the 755-nm alexandrite picosecond laser seems to be safe and effective for the esthetic treatment of gingival hyperpigmentation.
关键词： Pigment laser,Alexandrite laser,Picosecond laser,Laser
更新于2025-09-12 10:27:22
-
Use of 3-Dimensional Imaging in Submental Fat Reduction Following Hyperthermic Laser Lipolysis
摘要： In a randomized controlled study, patients with a wide variety of hypopigmented scars, and striae alba had mean final pigment correction rates of approximately 100% by colorimetric analysis after 9 treatments of 308-nm excimer laser biweekly. However, maintenance treatment every 1 to 4 months is suggested because the pigment gradually declined toward baseline values during a 6-month follow-up. Although the authors performed 308-nm excimer light only once weekly for 6 times in our patient, she had a good response and rapid repigmentation within 3 months, and no recurrence of hypopigmentation was found at a 10-month follow-up. A possible hypothesis is that she had no genetic predisposition for vitiligo, and she had a darker Fitzpatrick skin type. Patients with Fitzpatrick skin Type III and above generally respond better to an excimer laser than those with lower skin types. To the best of our knowledge, this is the first case of corticosteroid-induced perilymphatic linear hypopigmentation treated with 308-nm excimer light.
关键词： hypopigmented scars,Fitzpatrick skin type,pigment correction,308-nm excimer laser,striae alba
更新于2025-09-12 10:27:22