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Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)
摘要： More than 50 papers on surface plasmon resonance biosensors, published between 2016 and mid-2018, are reviewed. Papers concerning the determination of large particles such as vesicles, exosomes, cancer cells, living cells, stem cells, and microRNA are excluded, as these are covered by a very recent review. The reviewed papers are categorized into five groups, depending on the degree of maturity of the reported solution; ranging from simple marker detection to clinical application of a previously developed biosensor. Instrumental solutions and details of biosensor construction are analyzed, including the chips, receptors, and linkers used, as well as calibration strategies. Biosensors with a sandwich structure containing different nanoparticles are considered separately, as are SPR (Surface Plasmon Resonance) applications for investigating the interactions of biomolecules. An analysis is also made of the markers determined using the biosensors. In conclusion, there is shown to be a growing number of SPR applications in the solution of real clinical problems.
关键词： antibodies,cancer markers,surface plasmon resonance,receptor immobilization,biosensors,nanoparticles
更新于2025-09-04 15:30:14
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[SpringerBriefs in Materials] Anisotropic Metal Chalcogenide Nanomaterials (Synthesis, Assembly, and Applications) || Applications
摘要： Interest in anisotropic 1D and 2D nanostructures has been steadily increasing due to their large surface area, quantum con?nement effect, and superior optoelectrical or thermoelectrical properties. Anisotropic geometry and size reduction comparable to the Debye length can alter the optical, electric, and magnetic properties of the bulk counterparts. Focusing on MCs prepared in solution the major interests for practical applications are thermoelectric power phases, generation or electronic device cooling, high performance electrodes for batteries, nanocrystal-based photovoltaic devices, and photodetectors. Recently, new potential uses of the solution-based MC nanocrystals are being investigated, which include localized surface plasmon resonance (LSPR) and oxygen reduction reaction (ORR). MC thin ?lms prepared by the vacuum process have shown the possibilities as new class of materials such as topological insulator, semiconductor with a high electron mobility, and superconductor. Although the organic surfactants indispensable in solution chemistry diminish such superior physical properties, solution-based approach has large room to achieve such physical properties. This chapter will introduce recent advances in the practical applications of the anisotropic MC nanocrystals, and introduce brie?y the potential applications.
关键词： thermoelectric,oxygen reduction reaction,photodetector,metal chalcogenides,localized surface plasmon resonance,photovoltaic,superconductor,topological insulator,anisotropic nanostructures
更新于2025-09-04 15:30:14
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Comparative hyperthermia effects of silica–gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells
摘要： Silica–gold nanoshell (SGNS), which is a silica core surrounded by a gold layer, was synthesized by seed-mediated coalescence of gold clusters in an electroless plating solution. SGNS variations with different surface coverage of gold clusters were prepared by adjusting the amounts of gold salts in the presence of formaldehyde-reducing agents. Fully covered SGNS (f-SGNS) with connected gold clusters exhibited stronger intensity and more redshift of plasmon bands located around 820 nm than those of partially covered SGNS (p-SGNS) with disconnected gold clusters. Upon irradiation with near-infrared light (30 W/cm2, 700–800 nm), f-SGNS caused a larger hyperthermia effect, generating a large temperature change (?T =42°C), as compared to the relatively small temperature change (?T =24°C) caused by p-SGNS. The therapeutic antibody, Erbitux? (ERB), was further conjugated to SGNS for specific tumor cell targeting. The f-ERB-SGNS showed excellent therapeutic efficacy based on the combined effect of both the therapeutic antibody and the full hyperthermia dose under near-infrared irradiation. Thus, SGNS with well-controlled surface morphology of gold shells may be applicable for near-infrared-induced hyperthermia therapy with tunable optical properties.
关键词： gold nanoshell,plasmon resonance,human epithelial cancer,Erbitux,hyperthermia
更新于2025-09-04 15:30:14