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Photocatalytic degradation of pharmaceutical micro-pollutants using ZnO
摘要： This research paper presents the results of an experimental investigation of the degradation of three different contaminants including progesterone (PGS), ibuprofen (IBU), and naproxen (NAP) using ZnO as the photocatalyst and ultraviolet (UV) light as a source for catalysts activation. Two operating parameters, namely, catalyst loading and initial concentration of contaminants, were tested in a batch photocatalytic reactor. To demonstrate the large-scale applications, experiments were also conducted in a submerged membrane photocatalytic reactor. It has proven that ZnO photocatalyst degraded the three contaminants very efficiently under almost all the studied experimental conditions, with efficiency rates of 92.3, 94.5, and 98.7 % for PSG, IBU, and NAP, respectively. The photodegradation kinetics study was performed to calculate the reaction rate constant, which is found to follow pseudo-first order kinetics. The membrane photocatalytic reactor was efficient to remove pollutants and it is observed that the degradation rate increases with increasing the membrane oscillation frequency approaching that of the stirred reactor.
关键词： Photocatalytic degradation,Progesterone,Ibuprofen,Photocatalytic batch reactor,Naproxen,Oscillatory membrane reactor,ZnO
更新于2025-09-23 15:22:29
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Improvement of photocurrent and progesterone degradation by employing WO3 films modified with platinum and silver nanoparticles
摘要： The effect of silver (Ag0) and platinum (Pt0) metallic nanoparticles (NPs) on WO3 film was investigated by studying the photocurrent response under polychromatic irradiation. The structural phase revealed by X-ray diffraction (XRD) analysis indicates a monoclinic crystal nanostructure. WO3, Ag0/WO3, and Pt0/WO3 electrodes were used to degrade 0.35 mg L-1 progesterone hormone in aqueous solution under polychromatic irradiation for 3h. These studies on degradation were investigated under conditions of heterogeneous photocatalysis (HP) and electrochemically assisted HP (EHP). For photodegradation of progesterone, higher performance was achieved when WO3 was functionalized and when the EHP configuration was adopted with bias at +0.7 V vs Ag/AgCl. This work reveals that the incorporation of metallic NPs onto a semiconductor increases its efficiency, preventing electron-hole recombination in the photocatalyst and photoelectrochemical limitations of WO3 due surface plasmon resonance (SPR) and the trapping state. Therefore, efficient advances in the degradation of organic contaminants during water treatment can be realized based on this study.
关键词： Progesterone photodegradation,Polychromatic irradiation,Metals nanoparticles,WO3 films,Photocurrent density
更新于2025-09-23 15:21:01
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Quantitative of progesterone using isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry
摘要： A quantification assay based on isotope dilution mass spectrometry to determine the concentration of progesterone in human serum was reported. Incorporated with 13C3-progesterone, serum samples were subjected to progesterone extraction and clean-up by C4 solid-phase-extraction columns and hexane-based liquid/liquid extraction, respectively. The cleaned-up serum samples were then subjected to MALDI-TOF mass spectrometry for the quantification of progesterone. In the study, the recovered progesterone concentration determined by the assay showed good robustness and constancy in comparison to conventional radioimmunologic assay. We concluded that the 13C3-progesterone-based quantification assay is a robust method for the measurement of serum progesterone.
关键词： Isotope dilution,MALDI-TOF/MS,Progesterone
更新于2025-09-23 15:19:57
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Progesterone anti-inflammatory properties in hereditary retinal degeneration
摘要： The interactions between steroid gonadal hormones and the retina (a part of the visual system and the central nervous system (CNS)) have received limited attention and beneficial effects of these hormones in retinal diseases is controversial. Retinitis pigmentosa (RP) is the most common cause of retinal hereditary blindness and to date no treatment is available. However, results regarding the effects of progesterone on the progression of RP are promising. With the idea of demonstrating if the progesterone retinal protection in RP is related to its possible anti-inflammatory properties, we have administered orally progesterone to rd10 mice, an animal model of RP. We observed that progesterone decreased photoreceptors cell death, reactive gliosis and the increase in microglial cells caused by RP. We also examined the expression of neuronal and inducible nitric oxide synthase (nNOS and iNOS), the enzyme responsible for NO production. The results demonstrated a decrease in nNOS expression only in control mice treated with progesterone. Inflammation has been related with an increase in lipid peroxidation. Noticeably progesterone administration was able to diminish retinal malondialdehyde (MDA, a lipid peroxidation product) concentrations in rd10 mice. Altogether, we can conclude that progesterone could be a good therapeutic option not only in RP but also for other retinal diseases that have been associated with inflammation and lipid peroxidation.
关键词： retinitis pigmentosa,glia,malondialdehyde,inflammation,progesterone
更新于2025-09-19 17:15:36
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Quantitative analysis of progesterone using isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for radioimmunoassay
摘要： Background: Progesterone is one of the female steroid hormones and plays an important role in the menstrual cycle and during pregnancy. It is especially important in preparing the uterus for the implantation of the blastocyst and maintaining pregnancy. The concentration in human serum is measured to determine the ovarian function retroactively and the cause of abortion in early pregnancy. Methods: A quantification assay based on isotope dilution mass spectrometry to determine the concentration of progesterone in human serum is reported. Incorporated with 13C3-progesterone, serum samples were subjected to progesterone extraction and clean-up by C4 solid-phase-extraction columns and hexane-based liquid/liquid extraction, respectively. The cleaned-up serum samples were then subjected to MALDI-TOF mass spectrometry for the quantification of progesterone. Results: Progesterone and the internal standard, 13C3-progesterone, were measured in the selected reaction monitoring mode for the transitions m/z 315.4 to 108.9 and m/z 318.4 to 111.9, respectively. We calculated the peak area ratio of progesterone to 13C3-progesterone in the mass spectrometry. The progesterone concentration in human serum was calculated by substituting the peak area ratio into an isotope dilution calibration curve, and then compared with the radioimmunoassay. Conclusions: In the study, the concentrations of serum progesterone were measured, and the recovered progesterone concentration determined by the assay showed good robustness and consistency in comparison to the conventional radioimmunologic assay. We concluded that the 13C3-progesterone-based quantification assay is a robust method for the measurement of serum progesterone.
关键词： isotope dilution,radioimmunologic assay,MALDI-TOF/MS,progesterone
更新于2025-09-11 14:15:04
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Measuring Estrogen Receptor Functionality using Progesterone Receptor PET Imaging: Rising to the (Estradiol) Challenge!
摘要： Prognosis and therapy choice for breast cancer greatly depend upon pathohistological evaluation of biopsies and surgical samples. More specifically, the Estrogen Receptor (ER) – Progesterone Receptor (PR) – human epidermal growth factor receptor 2 (HER2) triad provides crucial information on which clinicians guide their intervention. Indeed, positivity for one or several of those receptors indicates that the use of hormone- or immuno-therapy against their respective targets is likely to benefit the afflicted patient.
关键词： PET Imaging,Breast Cancer,Estradiol Challenge,Progesterone Receptor,Estrogen Receptor
更新于2025-09-10 09:29:36