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Application of experimental design and multivariate analysis in the on-line reaction monitoring of a Suzuki cross-coupling reaction by Raman spectroscopy and multivariate analysis
摘要： A Suzuki-coupling reaction for the construction of CeC bond was monitored using Raman spectroscopy. The effects of temperature and concentration on the reaction yield were investigated following a central composite design. The percent yield for each data was measured off-line using GCeMS. On-line monitoring reactions using Raman spectroscopy coupled with partial least squares (PLS) were used for building a prediction model. Raman spectra collected from five experiments at different sampling times were used in building the model. The PLS model was then validated and results showed that the yield of reaction can be predicted well with high accuracy by the model, both within and outside the experimental limits. The results presented here have shown that such model is well suited for monitoring Suzuki-coupling reactions that are widely used in chemical and pharmaceutical industries.
关键词： Raman spectroscopy,Multivariate data analysis,Reaction monitoring,Suzuki cross-coupling
更新于2025-09-23 15:21:21
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Localized surface plasmon resonance scattering imaging and spectroscopy for real-time reaction monitoring
摘要： In the last decade, plasmonic nanoparticles-based scattering imaging and spectroscopy has introduced the analysis and sensing to the single nanoparticle and molecule level, such as the biomolecules adsorption process and the quantitative detection of small molecules and ions. Recently, this technology has also been focus on the real-time and in-situ reaction monitoring, which is a new emerging branch of the single-nanoparticle imaging, revealing the reaction dynamic information and the related controlling factors. In this mini-review, recent applications of plasmon resonance scattering imaging and spectroscopy in the real-time reaction monitoring in the past 5 years are highlighted and discussed.
关键词： single nanoparticle level,Localized surface plasmon resonance,plasmonic nanoparticles,scattering imaging,reaction monitoring
更新于2025-09-19 17:15:36
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[IEEE 2019 IEEE International Conference on Consumer Electronics - Asia (ICCE-Asia) - Bangkok, Thailand (2019.6.12-2019.6.14)] 2019 IEEE International Conference on Consumer Electronics - Asia (ICCE-Asia) - Development of Automated LED Light Compensation System for Lycopersicon Esculentum
摘要： The cells in an organism emit different amounts of proteins according to their clinical state (healthy/pathological, for instance). The resulting proteomic pro?le can be used for early detection, diagnosis, and therapy planning. In this paper, we study the classi?cation of a proteomic sample from the point of view of an inverse problem with a joint Bayesian solution, called inversion-classi?cation. We propose a hierarchical physical forward model and present encouraging results from both simulation and clinical data.
关键词： proteins,classi?cation algorithms,proteomics,Statistical signal processing,probability,liquid chromatography,mass spectrometry,selective reaction monitoring,inverse problems,mathematical modelling
更新于2025-09-19 17:13:59
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Extending Surface‐Enhanced Raman Spectroscopy to Liquids using Shell‐Isolated Plasmonic Superstructures
摘要： Plasmonic superstructures (PS) based on Au/SiO2 were prepared for Shell-Isolated Nanoparticle-Enhanced Raman Spectroscopy (SHINERS) in liquid phase applications. These superstructures are composed of functionalized SiO2 spheres with plasmonic Au nanoparticles (NPs) on their surface. Functionalization was performed with (3-aminopropyl)-trimethoxysilane, and poly(ethylene-imine) (PEI). Of these three, PEI-functionalized spheres showed the highest adsorption density of Au NPs in TEM, UV/Vis and dynamic light scattering (DLS) experiments. Upon decreasing the Au NP/SiO2 sphere size ratio, an increase in adsorption density was also observed. To optimize plasmonic activity, 61 nm Au NPs were adsorbed onto 900 nm SiO2-PEI spheres and these PS were coated with an ultrathin layer (1–2 nm) of SiO2 to obtain Shell-Isolated Plasmonic Superstructures (SHIPS), preventing direct contact between Au NPs and the liquid medium. Zeta potential measurements, TEM and SHINERS showed that SiO2 coating was successful. The detection limit for SHINERS using SHIPS and a 638 nm laser was around 10?12 m of Rhodamine (10?15 m for uncoated PS), all with acquisition settings suitable for catalysis applications.
关键词： Raman spectroscopy,plasmonic nanoparticles,reaction monitoring,heterogeneous catalysis,SERS
更新于2025-09-19 17:13:59