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[IEEE 2018 International Joint Conference on Neural Networks (IJCNN) - Rio de Janeiro (2018.7.8-2018.7.13)] 2018 International Joint Conference on Neural Networks (IJCNN) - Study of Clinical Staging and Classification of Retinal Images for Retinopathy of Prematurity (ROP) Screening
摘要： Retinopathy of Prematurity (ROP) is a disease which requires immediate precautionary measures to prevent blindness in the infants, and this condition is prevalent in premature babies in all the underdeveloped, developing, and in the developed countries as well. This paper proposes a tool by which the stage and zones of Retinopathy of Prematurity in infants can be diagnosed easily. This tool takes the input from the Retcam and detects the stage, zone, and gives a rating of 1 to 9 for classifying the severity of the disease in the infants. This is achieved by extracting the optic disc, marking the ridge, and the distance of the optic nerve. This tool can be easily used by nurses and paramedics, unlike the existing technologies which require the guidance of a specialist to come to a conclusion.
关键词： Retina,Retcam,Zones,Retinopathy,Stage,Optic disc,Optic nerve
更新于2025-09-04 15:30:14
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Novel codon 15 RHO gene mutation associated with retinitis pigmentosa
摘要： To describe, in a multimodal way, a new RHO gene mutation with lysine-for-asparagine substitution in autosomal dominant retinitis pigmentosa. Methods: Case report. Retrospective data analysis. Results: The mutation is located within codon 15 of exon 1 of the RHO gene. A single base-pair transversion lead to a specific lysine-for-asparagine substitution (Asn15Lys). Hypoacusis, myopia, dyschromatopsis and diffuse retinitis pigmentosa were detected. Detailed multimodal images for the posterior segment are presented. Conclusion: We present a new mutation with a specific substitution that may cause eye disease and which has not been described previously. There is no description of this variant in the genetic databases.
关键词： rod-cone dystrophy,retinal pigments,opsins,pigmentary retinopathy,tapetoretinal degeneration
更新于2025-09-04 15:30:14
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Choroidal Thickness at the Outside of Fovea in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography
摘要： Purpose: To evaluate choroidal thickness at the outside of the fovea in patients with diabetic retinopathy using spectral-domain optical coherence tomography. Methods: We examined 87 eyes of 87 patients with diabetic retinopathy and 40 eyes of 40 normal patients. Patients with diabetic retinopathy were divided into 3 groups according to the grade of diabetic retinopathy and macular edema. The choroidal thickness was obtained at the fovea and outside of the fovea using enhanced depth imaging of Spectralis optical coherence tomography. One foveal and 8 peripheral images were selected and choroidal thickness was measured from the outer border of the retinal pigment epithelium to the inner scleral border. Results: Subfoveal choroidal thickness was thinner with increasing severity of diabetic retinopathy. However, there was no significant difference between groups without the nasal side of the fovea. A statistically significant difference was observed over the fovea at the superotemporal area. Conclusions: The choroidal thickness outside of the fovea was thinner with the severity of diabetic retinopathy and was more pronounced in the superotemporal area.
关键词： Optical coherence tomography,Diabetic retinopathy,Choroidal thickness,Enhanced depth imaging
更新于2025-09-04 15:30:14
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A Case of Acute Bilateral Solar Retinopathy Diagnosed with Spectral Domain Optical Coherence Tomography
摘要： To report a case of acute bilateral solar retinopathy diagnosed using spectral domain optical coherence tomography (SD-OCT). Case summary: A 74-year-old female patient consulted for amblyopia and metamorphopsia at a local hospital. On the patient’s first visit, there were no abnormal findings based on slit lamp microscope. Additional examinations were conducted since the patient complained of metamorphopsia with visual acuity and corrected vision. Fundus photography and SD-OCT examination showed symmetrical lesions near the bilateral macula. Several evaluations of the patient’s medical history confirmed that the patient was exposed directly to the sun for 30 minutes. One month after the first visit, visual acuity improved but metamorphopsia remained unchanged. Lesion status could not be confirmed by fundus photography. There was no abnormal finding on fluorescence angiography. SD-OCT examination still showed bilateral symmetric disruption of the outer retina but with no significant interval change. Conclusions: In the present case, the patient with bilateral intraocular lenses who complained of acute binocular amblyopia was diagnosed accurately through SD-OCT tests for bilateral symmetric disruption on the outer retina and repetitive evaluations of patient’s medical history.
关键词： Spectral domain optical coherence tomography (SD-OCT),Acute bilateral solar retinopathy,Patient’s medical history,Disruption
更新于2025-09-04 15:30:14
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Multifocal Pupillography Identifies Changes in Visual Sensitivity According to Severity of Diabetic Retinopathy in Type 2 Diabetes
摘要： PURPOSE. Retinal light sensitivity loss has been shown to occur prior to other signs of retinopathy and may predict the sight-threatening sequelae. A rapid, objective perimetric test could augment diabetes care. We investigated the clinical use of multifocal pupillographic objective perimetry (mfPOP) to identify patients with and without diabetic retinopathy. METHODS. Retinopathy severity was determined using the Early Treatment of Diabetic Retinopathy Study (ETDRS) standard for fundus photography. Pupillary responses were measured from both eyes of 25 adults with none to moderate diabetic retinopathy and 24 age-matched controls, using three mfPOP stimulus variants. Multifocal pupillographic objective perimetry stimulus variants tested 44 regions per eye arranged in a ?ve-ring dartboard layout presented within either the central 308 or 608 of ?xation. Receiver operator characteristic (ROC) curves were produced from contraction amplitudes and time to peak responses. RESULTS. Regression analysis revealed that mean amplitude deviations were larger with severity of early retinopathy. On average, the longest delays were measured in patients with no retinopathy. The brightest wide-?eld stimuli produced the highest area under the ROC curve for differentiating eyes with no retinopathy from nonproliferative diabetic retinopathy (NPDR) and from healthy eyes (100 6 0.0%, mean 6 SE). The asymmetry in local delay deviations between eyes tended to produce higher sensitivity and speci?city than amplitude deviations. CONCLUSIONS. Asymmetry in local response delays measured by mfPOP may provide useful information regarding the severity of diabetic retinopathy and may have clinical use as a rapid, noninvasive method for identifying functional loss even in the absence of NPDR.
关键词： type 2 diabetes,pupils,objective perimetry,diabetic retinopathy,multifocal
更新于2025-09-04 15:30:14
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A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy
摘要： Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA-miRNA-mRNA interactions in DR are poorly understood. In the present study, we aimed to compute a global triple network of competitive endogenous RNAs (ceRNAs) in order to pinpoint essential molecules. We found that there were 802 nodes (121 lncRNA nodes, 17 miRNA nodes, and 664 mRNA nodes) and 949 edges in the ceRNA network. Further functional analysis suggested that some molecules were specifically related to DR. Surprisingly, these molecules were involved in visual perception, eye development, and lens development in camera-type eye. In summary, our study highlighted specific lncRNAs and miRNAs related to the pathogenesis of DR, which might be used as potential diagnostic biomarkers and therapeutic targets for DR.
关键词： lncRNA,diabetic retinopathy,ceRNA,miRNA
更新于2025-09-04 15:30:14