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Case Report: SPECT/CT as the New Diagnostic Tool for Specific Wrist Pathology
摘要： Introduction: Single photon emission computed tomography has been introduced as a promising new diagnostic tool in orthopaedic pathology since the early 90'. Computed tomography, the combined with SPECT, gives insight in the specific sight of wrist pathology. Literature already supports introduction of SPECT/CT in wrist pathology, but clinical application is lagging. Case Report: A 40yr old patient reported first in 2004 with persisting pain after a right distal radius fracture. Several diagnostics and operative interventions were performed, all unsuccessful. Because of the persisting pain a SPECT-CT was performed which showed a cyst in the hamate bone, which was successfully enucleated. The patient was finally pain free at recent follow-up. With a QDash-score of 43 and a PRW (H) E-DLV-score of 58/150. Discussion: In this case report, SPECT/CT proved a very sensitive diagnostic tool for specific pathology of the wrist. It offered precise localisation and thereby the clinically suspected diagnosis was confirmed and the patient successfully treated.
关键词： Capitate,Proximal row carpectomy,Wrist,SPECT/CT,Hamate,Single-Photon Emission-Computed Tomography
更新于2025-09-23 15:21:01
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<p>Preparation and SPECT/CT Imaging of <sup>177</sup>Lu-Labeled Peptide Nucleic Acid (PNA) Targeting CITED1: Therapeutic Evaluation in Tumor-Bearing Nude Mice</p>
摘要： The expression of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is upregulated in papillary thyroid carcinoma (PTC) and mediates cell proliferation and migration. To facilitate early diagnosis and monitoring of recurrent or metastatic PTC, we designed 177Lu-labeled antisense peptide nucleic acid (PNA) targeting CITED1 mRNA to evaluate the therapeutic potential, while analyzing its distribution in nude mice and the characteristics with single-photon emission-computed tomography/computed tomography (SPECT/CT) imaging.
关键词： SPECT/CT imaging,antisense therapy,diagnosis and treatment integration,papillary thyroid carcinoma
更新于2025-09-19 17:13:59
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Cancer Theranostics || Multimodality Image-Guided Treatment
摘要： Recent advances in molecular biology and imaging technology with precision engineering have allowed in vivo imaging of anatomic structures at submillimeter ranges and pathologic processes at subnanomolar concentrations. Multimodality imaging is exemplified by the current practice of single photon emission computed tomography (SPECT-CT) and positron emission tomography computed tomography (PET-CT) [1]. Subcentimeter lesions on computed tomotraphy (CT) can be characterized by functional abnormalities identified on SPECT to enhance sensitivity of detecting radio-isotopes or PET, which routinely assess lesion glucose metabolism using F-18 FDG (fluorine-18 fluoro-2-fluorodeoxyglucose). Conversely, subcentimeter hypermetabolic lesions on SPECT or PET can be identified on CT to allow exact localization to guide various types of therapy including surgery, radiotherapy, and experimental therapies. Guided therapies target abnormal tissues, which often refer to, but are not limited to, neoplasms. For instance, drainage of an abdominal bacterial abcess may require scintigraphic confirmation of infection to determine the need of intervention and anatomic guidance from CT or magnetic resonance imaging (MRI) to access the lesion.
关键词： Cancer treatment,Radiotherapy,Multimodality imaging,PET-CT,SPECT-CT,Surgery,Image-guided therapy,Molecular imaging
更新于2025-09-10 09:29:36
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<sup>111</sup> In-DANBIRT <i>In Vivo</i> Molecular Imaging of Inflammatory Cells in Atherosclerosis
摘要： Atherosclerosis-related morbidity and mortality remain a global concern. Atherosclerotic disease follows a slow and silent progression, and the transition from early-stage lesions to vulnerable plaques remains difficult to diagnose. Inflammation is a key component of the development of atherosclerotic plaque and consequent life-threatening complications. This study assessed 111In-DANBIRT as an in vivo, noninvasive SPECT/CT imaging probe targeting an inflammatory marker, Lymphocyte Function Associated Antigen-1 (LFA-1), in atherosclerotic plaques. Methods. Selective binding of 111In-DANBIRT was assessed using Sprague-Dawley rats exposed to filtered air and ozone (1 ppm) by inhalation for 4 hours to induce a circulating leukocytosis and neutrophilia in peripheral blood. After 24 hours, whole blood was collected and incubated with radiolabeled DANBIRT (68Ga-DANBIRT and 111In-DANBIRT). Isolated cell component smeared slides using cytospin technique were stained with Wright-Giemsa stain. Apolipoprotein E-deficient (apoE?/?) mice were fed either a normal diet or a high-fat diet (HFD) for 8 weeks. Longitudinal SPECT/CT imaging was performed 3 hours after administration at baseline, 4, and 8 weeks of HFD diet, followed by tissue harvesting for biodistribution, serum lipid analysis, and histology. 3D autoradiography was performed in both groups 24 hours after administration of 111In-DANBIRT. Results. Increased specific uptake of radiolabeled DANBIRT by neutrophils in the ozone-exposed group was evidenced by the acute immune response due to 4-hour ozone exposure. Molecular imaging performed at 3 hours using SPECT/CT imaging evidenced an exponential longitudinal increase in 111In-DANBIRT uptake in atherosclerosis lesions in HFD-fed mice compared to normal-diet-fed mice. Such results were consistent with increased immune response to vascular injury in cardiovascular and also immune tissues, correlated by 24 hours after administration of 3D autoradiography. Histologic analysis confirmed atherosclerotic disease progression with an increased vascular lesion area in HFD-fed mice compared to normal-diet-fed mice. Conclusion. 111In-DANBIRT is a promising molecular imaging probe to assess inflammation in evolving atheroma and atherosclerotic plaque.
关键词： Molecular imaging,Atherosclerosis,Inflammation,SPECT/CT,111In-DANBIRT,LFA-1
更新于2025-09-08 09:54:20