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Latent fingermark detection using functionalised silicon oxide nanoparticles: Method optimisation and evaluation
摘要： The application of nanoparticles for latent fingermark detection has been reported in the literature over the past two decades. One of the nanoparticles that shows promise to become a routine technique is functionalised silicon oxide nanoparticles (SiO2 NPs). In a recent optimisation of the technique, the use of carboxyl-functionalised SiO2 NPs doped with luminescent ruthenium complex was proposed as a breakthrough for latent fingermark detection. In this study, the aforementioned functionalised SiO2 NPs were extensively evaluated. Modification and optimisation of the original detection parameters were performed to enhance detection quality and improve applicability. Various detection parameters were evaluated and assessed. A lower concentration of the functionalised nanoparticles used in the colloidal dispersion was determined to offer improved detection effectiveness. A combination of increased bath temperature and reduced immersion time was found to produce good overall results. A set of modified detection parameters was suggested for the use of the functionalised SiO2 NPs to detect latent fingermarks. Performance of the modified detection parameters was compared against that of the published detection method. Comparison experiments were carried out on fingermark specimens deposited on aluminium foil, transparent polypropylene plastic and green polyethylene plastic. Three donors (weak, average and strong) and two age intervals (ten days and three months) were considered in the comparison study. Evaluation of the results suggested that the overall performance of the modified method for latent fingermark detection was superior to that obtained using the previously published detection parameters.
关键词： Bath temperature,Detection effectiveness,Method modification,Colloidal,Surface functionalisation,Luminescence technique
更新于2025-11-19 16:46:39
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Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation
摘要： Quantum dots (QDs) are promising nanomaterials due to their unique photophysical properties. For them to be useful in biological applications, the particle surface generally needs to be conjugated to biological molecules, such as antibodies. In this study, we screened CdTe/CdS QD-binding peptides from a phage display library as linkers for simple and bio-friendly QD modification. Among five QD-binding peptide candidates, a series of truncated peptides designed from two high-affinity peptides were subjected to an array-based binding assay with QDs to assess their functional core sequences and characteristics. Linking these isolated, shortened peptides (PWSLNR and SGVYK) with an antibody-binding peptide (NKFRGKYK) created dual-functional peptides that are capable of QD surface functionalisation by antibodies. Consequently, the dual-functional peptides could mediate anti-CD9 antibody functionalisation onto CdTe/CdS QD surface; CD9 protein imaging of cancer cells was also demonstrated. Our proposed peptides offer an effective vehicle for QD surface functionalisation in biological applications.
关键词： surface functionalisation,Quantum dots,bioimaging,peptides,CdTe/CdS,phage display,antibody conjugation
更新于2025-09-23 15:19:57
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Graphene-Oxide and Hydrogel Coated FBG-Based pH Sensor for Biomedical Applications
摘要： A hydrogel coated fibre grating-based pH sensor for biomedical applications has been realised, where Graphene Oxide (GO) had been used to enhance the bonding between the coating and the fibre. Two methods of deposition of GO were analysed i.e., evaporation and co-electroplating. The paper concludes that the system of GO evaporated on the fibre + the hydrogel has a sensitivity much higher, (6.1 ± 0.5) pm/pH, than the system of Cu and GO co-electroplated + the hydrogel, (1.9 ± 0.1) pm/pH, for a pH range between 2 to 10. The other conclusion is that the first system has a less coating bonding energy with the optical fibre whereas the second system has a stronger bonding energy, with better durability.
关键词： FBG,surface functionalisation,pH,sensing,fibre optic,biomedical application,roughness,graphene oxide,wettability,GO
更新于2025-09-04 15:30:14