- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
[IEEE 2019 IEEE International Conference on Electron Devices and Solid-State Circuits (EDSSC) - Xi'an, China (2019.6.12-2019.6.14)] 2019 IEEE International Conference on Electron Devices and Solid-State Circuits (EDSSC) - Simulation and analysis of p-ZnSiP <sub/>2</sub> /n-Si heterojunction solar cells
摘要： Ethnopharmacological relevance: Liu-Shen-Wan (LSW) is one of the popular over-the-counter drugs in Asia, which contains realgar (As4S4), used for the treatment of upper respiratory tract inflammation and skin infections. However, the safety and potential risk of this arsenic remain unknown. Aim of the study: The aim of this study was to determine total arsenic in tissue and investigate effects of regular dose and overdose LSW exposure on rat liver. Materials and methods: We used a target lipidomics approach to quantify inflammatory eicosanoids and employed ICP-MS to determine total arsenic in tissue. Results: The results showed that oral administration of 8 and 40 mg/kg LSW (1 and 5 fold human-equivalent dose) induced light changes of liver lipidomic profile in rats, which was associated with anti-inflammatory function of LSW. In our recent report, we observed that 41 and 134 mg/kg realgar (40 and 132 fold human-equivalent dose) stimulated rat liver inflammation through up-regulation of pro-inflammatory LOX-derived, CYP-derived HETEs and COX-derived PGs. However, we found that LSW in the form of drug combination, containing 41 and 134 mg/kg realger, could not stimulate these similar inflammatory responses in rats, although the liver total arsenic levels of the realger and LSW groups were same. Conclusion: The downregulation of pro-inflammatory showed that the LSW containing realger is safer than realger alone administrated to rats. These results suggested that Chinese medicines combination could reduce realgar-derived arsenic toxicity in rats.
关键词： Chinese medicine compatibility,Reducing toxicity,Liu Shen Wan,Realgar,Liver inflammation
更新于2025-09-11 14:15:04
-
Photobiomodulation for the treatment of retinal diseases: a review
摘要： Photobiomodulation (PBM), also known as low level laser therapy, has recently risen to the attention of the ophthalmology community as a promising new approach to treat a variety of retinal conditions including age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, Leber's hereditary optic neuropathy, amblyopia, methanol-induced retinal damage, and possibly others. This review evaluates the existing research pertaining to PBM applications in the retina, with a focus on the mechanisms of action and clinical outcomes. All available literature until April 2015 was reviewed using PubMed and the following keywords: 'photobiomodulation AND retina', 'low level light therapy AND retina', 'low level laser therapy AND retina', and 'FR/NIR therapy AND retina'. In addition, the relevant references listed within the papers identified through PubMed were incorporated. The literature supports the conclusion that the low-cost and non-invasive nature of PBM, coupled with the first promising clinical reports and the numerous preclinical-studies in animal models, make PBM well-poised to become an important player in the treatment of a wide range of retinal disorders. Nevertheless, large-scale clinical trials will be necessary to establish the PBM therapeutic ranges for the various retinal diseases, as well as to gain a deeper understanding of its mechanisms of action.
关键词： low level laser therapy,age-related macular degeneration,retinopathy of prematurity,photobiomodulation,retinal degeneration,amblyopia,far-red to near-infrared,methanol toxicity,retinitis pigmentosa
更新于2025-09-10 09:29:36
-
A multi-institutional retrospective study of carbon-ion radiotherapy for non-squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon-Ion Radiation Oncology Study Group study 1402 HN
摘要： Background: This multi‐institutional retrospective study focused on the clinical outcome of carbon‐ion radiotherapy (C‐ion RT) for non‐squamous cell malignant tumors of the nasopharynx. Methods: The Japan Carbon‐ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non‐squamous cell malignant tumors of the nasopharynx treated with C‐ion RT at four institutions in Japan. Results: Twenty‐nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies. Twenty‐six of the 43 patients (61%) had T4 tumors. The most common dose‐fractionation schedule was 64 Gy (relative biological effectiveness) in 16 fractions. The median follow‐up period was 30 months. The 2‐year local control (LC) and overall survival (OS) rates were 88% and 84%, respectively. For late toxicity, one patient developed grade 4 optic nerve disorder and two developed grade 5 pharyngeal hemorrhage. Actual incidence of grade 3 or higher late adverse events was 19%, and included cranial nerve dysfunction, jaw bone necrosis, central nervous system necrosis, and ear inflammation. Conclusions: C‐ion RT provided good LC and OS rates with acceptable toxicity for treatment of non‐squamous cell malignant tumors of the nasopharynx.
关键词： overall survival,carbon‐ion radiotherapy,non‐squamous cell malignant tumors of the nasopharynx,local control,toxicity
更新于2025-09-10 09:29:36
-
Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model
摘要： Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real‐time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)‐Pc in SHSy5Y neuroblastoma cells. We have established the non‐toxic concentration range of Ga(III)‐Pc, a compound which shows a high intracellular accumulation, with perinuclear distribution in confocal microscopy. By choosing Ga(III)Pc non‐toxic dose, we performed in vitro experimental PDT hampering cellular proliferation. Our proposed Ga(III)‐Pc could complete a future PS panel for neuroblastoma alternate therapy.
关键词： toxicity,gallium(III),photosensitizer,proliferation,tumour,photodynamic therapy,neuroblastoma,viability
更新于2025-09-10 09:29:36
-
Cytotoxic and Membrane Cholesterol Effects of Ultraviolet Irradiation and Zinc Oxide Nanoparticles on Chinese Hamster Ovary Cells
摘要： Zinc Oxide (ZnO) nanoparticles are suspected to produce toxic effects toward mammalian cells; however, discrepancies in the extent of this effect have been reported between different cell lines. Simultaneously, high levels of ultraviolet (UV-C) radiation can have carcinogenic effects. The mechanism of this effect is also not well understood. Due to similarities in phenotype morphology after cell exposure to ZnO nanoparticles and UV-C irradiation, we emit the hypothesis that the toxicity of both these factors is related to damage of cellular membranes and affect their sterol content. Wild-type Chinese Hamster Ovary (CHO-K1) cells were exposed to ZnO nanoparticles or UV-C radiation. The amount of absorbed ZnO was determined by UV-visible spectroscopy and the changes in sterol pro?les were evaluated by gas chromatography. Cell viability after both treatments was determined by microscopy. Comparing morphology results suggested similarities in toxicology events induced by ZnO nanoparticles and UV exposure. UV-C exposure for 360 min disrupts the sterol metabolic pathway by increasing the concentration of cholesterol by 21.6-fold. This increase in cholesterol production supports the hypothesis that UV irradiation has direct consequences in initiating sterol modi?cations in the cell membrane.
关键词： ZnO,cholesterol,toxicity,sterol content,UV-radiation
更新于2025-09-09 09:28:46
-
Transient liver toxicity as a result of the oral administration of 5-aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer
摘要： The clinical benefit of PDD-assisted TURBT with 5-ALA is evident from several studies.1–3 We carried out a phase III study of this new diagnostic technique in Japan using a preoperative oral administration of 20 mg/kg 5-ALA.2 On the basis of the reported high diagnostic accuracy and good safety profile, oral 5-ALA has been approved as an intraoperative diagnostic drug in Japan since December 2017. The toxicity induced by 5-ALA is reported to be low, because 5-ALA is a non-fluorescent natural amino acid produced by the mitochondria in animals and plants.3,4 However, 5-ALA administered into the body is predominantly incorporated by the liver, kidney, muscle and malignant tumor tissue, and metabolized to protoporphyrin IX in a heme synthetic pathway.5,6 Administration of 5-ALA is associated with a potential risk of liver toxicity as a result of the substantial accumulation of its metabolites.6,7 Although evidence regarding its liver toxicity has been reported in Europe and the USA, such data are significantly lacking for Japanese patients. In the present study, we systematically evaluated liver parameter reactions in patients with bladder cancer who underwent 5-ALA-mediated PDD-TURBT to recommend the routine surveillance required in the regular clinical setting.
关键词： liver toxicity,5-aminolevulinic acid,photodynamic diagnosis,bladder cancer
更新于2025-09-09 09:28:46
-
Stability and Microbial Toxicity of HfO <sub/>2</sub> and ZrO <sub/>2</sub> Nanoparticles for Photolithography
摘要： HfO2 and ZrO2 nanoparticles (NPs) have gained attention as components of photoresists for next-generation photolithography. Coating of these NPs with organic ligands has been shown to increase their efficiency in photolithography. This study evaluated the microbial toxicity of HfO2 and ZrO2 NPs coated with benzoate, isobutyrate, or methacrylate towards heterotrophic aerobes, methanogens, and the bioluminescent bacterium, Aliivibrio fischeri. The stability of NPs in the media was assessed as a function of zeta potential, particle size distribution, and leaching analyses. NP dispersions were unstable in all bioassay media, resulting in particle aggregation and settling. Leaching tests showed that dissolution of the organic ligands from the NPs varied widely depending on the nanomaterial and medium considered. The NPs were harmless to aerobic heterotrophs and methanogens at high concentrations (800-1200 mg L-1). In contrast, they displayed low to moderate toxicity to A. fischeri (50% inhibition at 286-1372 mg L-1), with benzoate-coated NPs causing the highest inhibition. Further analyses confirmed that the inhibition observed in assays with A. fischeri should be attributed to the coated NPs rather than to the dissolved organic ligands. Overall, the NP photoresists tested in this study are unlikely to exert acute microbial toxicity at environmentally relevant concentrations (sub-ppm levels).
关键词： stability,photolithography,HfO2,ZrO2,nanoparticles,microbial toxicity,leaching
更新于2025-09-09 09:28:46
-
Respective construction of Type-II and direct Z-scheme heterostructure by selectively depositing CdS on {001} and {101} facets of TiO2 nanosheet with CDots modification: A comprehensive comparison
摘要： Directional deposition has always been a focus issue in the construction of specific heterostructure. Herein, for the first time, we have demonstrated that the CdS could be selectively deposited on {001} or {101} facets of TiO2 nanosheet, and two different charge transfer processes were formed. First, the selective deposition of CdS on {001} facets of TiO2 nanosheet ({001}TiO2/CdS) would form the Type-II heterostructure, which seriously weakened the redox ability of {001}TiO2/CdS and directly resulted in the low photocatalytic performance (4-Chlorophenol (4-CP), 61.92% in 40 min) and serious photocorrosion of CdS. In contrary, the selective deposition of CdS on {101} facets of TiO2 nanosheet ({101}TiO2/CdS) could construct direct Z-scheme heterostructure with significantly increased photocatalytic 4-CP degradation efficiency (96.12%), much higher than pristine TiO2 nanosheet (87.21%). The hybrids were further modified by carbon nanodots (CDots) ({101}TiO2/CdS/CDots) to enhance photocatalytic performance (99.84%). The obtained direct Z-scheme {101}TiO2/CdS/CDots showed excellent stability and anti-photocorrosion ability. The synergistic effect between TiO2 nanosheet, CdS and CDots was expounded through characterization analyses, and the photocatalytic reaction mechanism was proposed in detail. Toxicity assessment authenticated good biocompatibility and low cytotoxicity of {101}TiO2/CdS/CDots. Our discovery was expected to drive great advances in the use of TiO2 nanosheet for environmental remediation.
关键词： Toxicity,Selective CdS deposition,Z-scheme heterostructure,TiO2 nanosheet,Anti-photocorrosion
更新于2025-09-09 09:28:46
-
Nanotechnology in Water and Wastewater Treatment || Photocatalytic Decolorization of Two Remazol Dyes Using TiO2 Impregnated Pumice Composite as Catalyst
摘要： This study, as a first attempt, aimed to evaluate photocatalytic decolorization of of two remazol dyes (blue and red) using TiO2 impregnated pumice composite catalyst. The SEM-EDX analysis showed that TiO2 nanoparticules were mostly impregnated on the pores of pumice with a ratio of 1.60% Ti. A 97.8% and 97.6% of color removal was achieved for RB and RR at pH 3, respectively, whereas those color removal percentages decreased to 57.4% and 53.9%, respectively, at pH 11 after 2 hours illumination. The color removal efficiencies of 97.8%, 82.7%, and 75.3% for RB dye and of 97.6%, 85.3%, and 84.0% for RR dye were observed after first, second, and third cycles reuse of the synthesized catalyst. Toxicity of photocatalytic treated samples of both dyes decreased below 50% after 90 and 120 minutes irradiation when they were diluted at 75%. This result indicate there is an urgent need to prolong the irradiation time and/or for increasing catalyst dose to completely remove toxicity in the undiluted samples.
关键词： TiO2 impregnated pumice composite,Remazol dyes,Photocatalytic decolorization,Toxicity,UV-A illumination
更新于2025-09-09 09:28:46
-
In vitro and In vivo evaluation of green-hydrothermal synthesized ZnO nanoparticles
摘要： ZnO nanoparticles synthesized using Gallic acid isolated from Phyllanthus emblica aqueous extract that designated as Pe ZnO, was subjected for structural and morphological characterization. For in vitro cyto-toxicity assessment of Pe ZnO, Hemolytic assay and Cell Counting Kit assay (CCK 8) on balb 3T3 fibroblasts were conducted while silkworm Bombyx mori larvae were used for in vivo bio-toxicity assay. In dentistry, clinically advocated ZnO (presented as D ZnO) of ~2 μm size was used as control. Characterization results revealed that Pe ZnO is highly crystalline with hexagonal wurtzite structure and morphologically spherical with an average size of 38 nm as confirmed by X-ray diffraction, electron microscopy and dynamic light scattering techniques. Haemolysis assay at all the tested concentrations exhibit that, lysis of Red Blood Cells by Pe ZnO remained well within toxicity limit of 3% whereas D ZnO showed ~5.2% hemolysis. Interestingly, Pe ZnO nanoparticles caused less than 36% growth inhibition of 3T3 cells at the highest concentration (2 μL) against 44% by D ZnO. Notably, in vivo study showed 26.67 and 96.67% death of the larvae at highest concentration 0.032 mg/mL of Pe ZnO and D ZnO respectively indicating Pe ZnO is less toxic than commercially available ZnO. Thus, we proved that green hydrothermally synthesized ZnO (PeZnO) is highly biocompatible and therefore propose to consider as potent compound for further evaluation using mammalian models followed by clinical trials.
关键词： Hydrothermal,3T3 fibroblasts,Green synthesis,ZnO,Bombyx mori,toxicity,Hemolysis
更新于2025-09-04 15:30:14