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A novel coumarin-based fluorescent probe for sensitive detection of copper(II) in wine
摘要： A novel coumarin-based fluorescent probe (probe 1) for the detection of copper(II) was developed. The fluorescence intensity of probe 1 showed a linear relationship with the concentration of copper(II) in the range 0–16 μM (0–1.02 mg/L) and the limit of detection was 62 nM (3.94 μg/L). The luminescence of probe 1 at the maximum allowable amounts of copper(II) in wine and water could be observed with the naked eye under a 365-nm ultraviolet lamp. Moreover, probe 1 was successfully used for the qualitative and quantitative detection of copper(II) in wine.
关键词： fluorescent probe,red wine,Copper(II)
更新于2025-09-19 17:15:36
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Direct and Rapid Multi-Element Analysis of Wine Samples in Their Natural Liquid State by Laser Ablation ICPMS
摘要： A simple and rapid method using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) for direct multi-element analysis of wine samples without any sample pretreatment is described. Bestowed to its micro-sample consumption, the proposed method offers advantages of direct multi-element analysis in wine samples with high ethanol (1%–20%) and salt contents, insignificant carbon deposits, reduced matrix effects, and better analytical performance. External calibration using either solid reference material NIST 610 glass or aqueous standard solutions in combination with indium internal standard provides accurate results. This calibration strategy offers a solution to the lack of a multi-element certified wine reference material for matrix-matched calibration. Twenty elements (Li, B, Mg, Al, V, Mn, Co, Cu, Zn, Rb, Sr, Y, Cs, Ba, La, Ce, Pr, Nd, Pb, and U) were determined in wine samples. The proposed method was validated by a comparison to the conventional solution nebulization ICPMS method, with satisfying results. The detection limits for these elements were 0.01–1 ng mL-1. The proposed method has a great potential for multi-element analysis in other beverages.
关键词： Direct analysis,ICPMS,Multi-element analysis,Laser ablation,Wine
更新于2025-09-19 17:13:59
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Immediate post‐irradiation dermoscopic vascular changes versus purpura as a therapeutic endpoint in pulsed‐dye laser treatment of port wine stains
摘要： Pulsed-dye laser (PDL) is the treatment of choice for port wine stain (PWS), and the development of purpura is considered a therapeutic endpoint. Changes in PWS vasculature observed by dermoscopy immediately after laser irradiation have been suggested to predict the minimal effective fluence. The current study aimed at comparing these changes with purpura as a therapeutic endpoint. Fifty-six PWS patients, randomized into two groups, received five monthly PDL sessions (595 nm and 10 mm spot size). At the first visit, patients received multiple gradually increasing test irradiations. Patients in the first group were treated with the lowest dose that resulted in 24-hr-lasting purpura, while patients in the second group were treated with the lowest dose that resulted in vessel disappearance observed by dermoscope. No statistically significant differences were observed between the two groups (the dermoscopic and the purpuric) regarding mean average improvement (42.4 and 37.32%, respectively, p = .32), grade of improvement (p = .44), and the rate of side effects (0 and 13.79%, respectively, p = .13). In conclusion, the immediate post-irradiation vessel disappearance (detected by dermoscope) is comparable, in safety and efficacy, to purpura as a therapeutic endpoint and maybe more time-saving and more accepted cosmetically.
关键词： pulsed-dye laser,port wine stain,dermoscopy
更新于2025-09-19 17:13:59
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Retrospective study of photodynamic therapy for pulsed dye lasera??resistant porta??wine stains
摘要： Pulsed dye laser-resistant port-wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser-resistant cervicofacial port-wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532-nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port-wine stain lesions were evaluated according to the L*a*b* color coordinate system, then the values of color changes (DE) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median DE decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2-month follow up (P < 0.001). The median blanching rate of port-wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (>50% color blanching). Adverse events were minimal, transient and self-limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser-resistant port-wine stains.
关键词： pulsed dye laser,pulsed dye laser resistance,treatment efficacy,photodynamic therapy,port-wine stain
更新于2025-09-19 17:13:59
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Facial Hypertrophic Port-Wine Stain Treatment Combining Large Spot 532 nm Laser, High-Intensity Focused Ultrasound and Traction Threads
摘要： Vascular lasers are the gold standard treatment for treating facial capillary malformations commonly known as port-wine stains (PWSs). However, up to 65% of them are associated with significant soft tissue hypertrophy that cannot be satisfactorily addressed using vascular lasers. The authors report a 40-year-old Caucasian woman with a large PWS of the mid and lower face and neck. It was unilateral and associated with significant hypertrophy of the affected face that resulted in significant asymmetry. Both face and neck had been previously treated with several sessions of different vascular lasers: 'small spot' potassium titanyl phosphate (532 nm) laser, intense pulsed light devices, and pulsed-dye laser (PDL). Pulsed-dye laser produced partial improvement of lesional color and was associated with minor scarring on her neck. Every previous treatment was stopped after several sessions when no further improvement was achievable. The authors initiated treatment with large spot, short pulse 532 nm laser with contact cooling (ExcelV; Cutera, Inc., Brisabane, CA; fluence 9–10 J/cm2, pulse duration 6 milliseconds, 8-mm spot on the cheek and 7–9 J/cm2, 6–7 milliseconds, 9-mm spot on the neck) every 4 weeks for the vascular component of her PWS. After 6 sessions, the authors obtained 34.61% improvement in lesional color and area, measured with objective 3-dimensional digital photography as described previously. To improve soft tissue hypertrophy and facial asymmetry, high-intensity focused ultrasound (HIFU) treatment was introduced (Ultraformer III; Classys, Inc., Seoul, Republic of Korea). The authors used 3 transducers working at the depths of 4.5, 3.0, and 1.5 mm, with energies 0.7, 0.6, and 0.4 J, respectively. A total of 600 lines were utilized in 2 sessions of 300 each with 2-week intervals. After 6 months, repositioning of hypertrophic cheek skin was performed with poly-L-lactic acid traction threads (Silhuette-Soft; Sinclair Pharma Ltd., Chester, United Kingdom). The authors used 2 threads with 12 cones (6 on each side) in 'V' shape fashion from 2 entry points in preauricular area and achieved immediate (data not shown) and delayed satisfactory results (Figure 1). The patient reported greater satisfaction from improved facial asymmetry than from color modification.
关键词： Traction Threads,High-Intensity Focused Ultrasound,Facial Hypertrophic Port-Wine Stain,532 nm Laser
更新于2025-09-16 10:30:52
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Harper's Textbook of Pediatric Dermatology || Laser Therapy
摘要： The pulsed dye laser has revolutionized the treatment of vascular anomalies. More recently, the multiplex laser, a combination of pulsed dye and Nd:YAG, has been shown to be beneficial for recalcitrant port wine stains and other conditions. In addition to their use in treating port wine stains, lasers have also an important role in treating a number of childhood pigmentary disorders. These are primarily congenital naevi such as café‐au‐lait macules, naevus of Ito and some blue lesions. Laser treatment is based on selective thermal destruction or damage to a targeted chromophore located in the skin, either that of blood, melanin or tissue water. Lasers have been shown to successfully treat vascular and pigmented lesions and also remove unwanted hair. They can also be used to remove verrucous lesions such as angiofibromas and epidermal naevi through vaporization.
关键词： pulsed dye laser,vascular anomalies,verrucous lesions,port wine stains,hair removal,selective photothermolysis,pigmentary disorders
更新于2025-09-16 10:30:52
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Vascular and Pigmented Lesions of Phacomatosis Pigmentovascularis Treated With a Combination of Long-Pulsed, Q-Switched Laser, and Picosecond Lasers
摘要： Phacomatosis pigmentovascularis (PPV) is a rare congenital condition characterized by the coexistence of port-wine stains (PWS) and various melanocytic lesions. Treatment should be considered, given the often extensive lesions and social impact. Of the approximate 250 reported cases of PPV, only 5 cases discuss treatment options. Laser therapy is widely used and successful in treating the individual lesions often seen in PPV. However, the collision of these red and brown pigments of different depths in the dermis, often on a background of darker skin, makes treatment of these lesions challenging. This case, and a review of 4 PPV treatment cases, highlights the success of combination laser treatment and addresses factors including age and choice of anesthesia that will optimize results.
关键词： melanocytic lesions,Phacomatosis pigmentovascularis,port-wine stains,PPV,laser therapy
更新于2025-09-12 10:27:22
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Treatment of port wine stains with 595-nm pulsed dye laser in 27 pediatric patients: A prospective study in the Iranian population
摘要： Port wine stain (PWS) is a congenital vascular malformation, which is visible at the birth as the red patches, mostly on the face and neck. Previous studies have shown good efficacy and safety of 595-nm pulsed dye laser (PDL). Here, we have conducted a prospective study to assess the efficacy and safety profile of pediatrics with PWS, treated with 595-nm PDL. Twenty-seven patients (10 males and 17 females) with the mean age of 5.7 ± 2.8 (range 1–13) years old were included in the study. Following 6.2 (range 4–10) sessions of treatment, 70.74 ± 18.5% of improvement was detected three months after the final session. Fourteen (51.8%) patients achieved a higher than 75% of improvement; nine (33.4%) patients experienced 50%-75% improvement; four (14.8%) patients experienced a less than 50% improvement. V1 involvement and a marked improvement within the first five sessions found to be good prognostic factors. Regarding age, sex, skin type, color and size of the PWS, no significant association with therapeutic response were detected. Blister and crust, atrophic macules, and hyperpigmentation were noted in six (22.2%), one (3.7%), and one (3.7%), respectively. In conclusion, 595-nm PDL looks an effective and relatively safe therapeutic approach in the treatment of Iranian pediatric PWS patients.
关键词： Port wine stain,pediatric,pulsed dye laser
更新于2025-09-12 10:27:22
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The influence of morphological distribution of melanin on parameter selection in laser thermotherapy for vascular skin diseases
摘要： Port wine stains (PWSs) are congenital vascular malformations that progressively darken and thicken with age. Currently, laser therapy is the most effective way in clinical management of PWS. It is known that skin pigmentation (melanin content) affects the radiant exposure that can be safely applied to treat PWS. However, the effect of melanin distribution in the epidermis on the maximum safe radiant exposure has not been studied previously. In this study, 10 different morphological distributions of melanin were proposed according to the formation and migration characteristics of melanin, and the two-scale heat transfer model was employed to investigate the influence of melanin distribution on the threshold radiant exposure of epidermis and blood vessels. The results show that melanin distributions do have a strong effect on laser parameter selection. When uniform melanin distribution is assumed, the threshold radiant exposure to damage a typical PWS blood vessel (50 μm diameter) is 8.62 J/cm2 lower than that to injure epidermis. The optimal pulse duration is 1–5 ms for a typical PWS blood vessel of 50 μm when melanin distribution is taken into consideration. PWS blood vessels covered by non-uniformly distributed melanin are more likely to have poor response to laser treatment.
关键词： Port wine stains,Melanin distribution,Two-scale model,Cryogen spray cooling,Laser treatment
更新于2025-09-12 10:27:22
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Efficacy of 577‐nm Pro‐Yellow laser in port wine stain treatment
摘要： A port-wine stain (PWS) is a congenital capillary malformation that is seen in 0.3–0.5% of newborns. Although many types of lasers have been used to treat PWSs, few studies have investigated the efficacy of 577-nm Pro-Yellow lasers. The aim of this study was to establish the efficacy of Pro-Yellow lasers in PWS treatment. In total, 26 patients, comprising 15 females (57.7%) and 11 males (42.3%) with a mean age of 24.7 ± 11.8 (range 1–50) years were included in the study. All were treated with a 577-nm Pro-Yellow laser at 4-week intervals, 3–10 times. The sessions initially used scan mode and a fluence dose of 24 J/cm2 per session, on average. The mean dose was increased by 4 J/cm each session and the maximum dose administered was 44 J/cm2. A mean regression of 68.8 ± 13.9% in the size of the lesions over 5.23 ± 2.7 sessions was observed. There was no statistically significant difference between the female and male patients when they were compared in terms of the number of treatment sessions (p = .789) and treatment success (p = .39). These case series demonstrate that the Pro-Yellow laser is a safe and well-tolerated treatment for PWSs. However, deep-seated lesions required more treatment sessions and it was observed that clinically the lesions did not completely disappear.
关键词： Pro Yellow laser,577 nm laser,laser treatment,port-wine stain
更新于2025-09-11 14:15:04