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Degradation of Ciprofloxacin and Inactivation of Ciprofloxacin Resistant E. Faecium during UV-LED (275 nm)/Chlorine Process
摘要： Ciprofloxacin and ciprofloxacin-resistant bacteria are emerging concerns that threaten public health due to the heavy use of antibiotics and the development of bacterial resistance in water environments. In this study, we examined an energy-efficient treatment driven by a UV-LED/chlorine reaction with UV-LED chip emitting UV275 nm to remove ciprofloxacin and ciprofloxacin-resistant bacteria in water. Ciprofloxacin degradation during the UV-LED/chlorine reaction followed pseudo-first-order kinetics, and the excessive chlorine dosage has a negative effect on ciprofloxacin removal. Alkaline pH showed the best efficiency for ciprofloxacin removal, and the reactive chlorine species (RCS) played a major role at alkaline pH values. The cleavages of piperazine, cyclopropyl, and quinolone moieties are considered as the principal degradation reactions in the UV-LED/chlorine reaction. Seven byproducts (m/z = 362.9262, 306.1246, 289.0995, 288.1504, 263.0825, 147.0657, and 1183.9977), two chlorinated compounds (chloroform and chlorate) and two anions (formate and nitrate ions) were observed as the identified byproducts. Toxicity of tentatively identified byproducts were estimated by using quantitative structure activity relationship (QSAR). The complete detoxification of D. magna was achieved when applying UV-LED/chlorine process into hospital wastewater containing CIP. The UV-LED/chlorine process showed the best disinfection ability of E. faecium compared to UV-LED photolysis, chlorination, and UV-LED/H2O2 reactions. A significantly lower EE/O value (6.63 × 10-2 kWh/m3/order) during the UV-LED/chlorine reaction was also observed. Our results indicate that the UV-LED/chlorine process can effectively degrade ciprofloxacin and inactivate ciprofloxacin-resistant bacteria.
关键词： toxicity,UV-LED,ciprofloxacin,byproducts,antibiotic-resistant bacteria,Chlorine
更新于2025-09-23 15:21:01
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A Synthetic Fluorescent Nanoplatform Based on Benzoxaborole for Broad-Spectrum Inhibition of Bacterial Adhesion to Host Cells
摘要： The rising prevalence of antibiotic-resistant bacteria pathogens has attracted increasing concern in the whole world. The anti-adhesion strategy without triggered bacterial resistance is currently considered a promising alternative to treat bacteria-induced infections. Here, we developed a novel bacteria-binding florescent polymeric nanoplatform for non-lethal anti-adhesion therapy of bacterial infections. This versatile platform will allow simultaneous bacterial agglutination and fluorescent reporting for both Gram-positive and Gram-negative bacteria by taking advantage of strong interaction between the benzoxaborole groups and diol moieties on bacterial surfaces. Furthermore, impressive performance of inhibiting biofilm formation was entirely shown in the generic cell-binding glues. The trapping nanoparticles were capable of taking invasive bacteria pathogens away from the infected host cells with negligible damage to neither bacterial nor host cells, which will not trigger drug resistance, indicating a far-reaching future of the potential application for anti-adhesion therapy of whole-bacterial infection diseases.
关键词： biofilm inhibition,fluorescent polymeric nanoplatform,anti-adhesion therapy,benzoxaborole,antibiotic-resistant bacteria
更新于2025-09-10 09:29:36