- 标题
- 摘要
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- 实验方案
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[IEEE 2019 IEEE 4th International Conference on Integrated Circuits and Microsystems (ICICM) - Beijing, China (2019.10.25-2019.10.27)] 2019 IEEE 4th International Conference on Integrated Circuits and Microsystems (ICICM) - A Laser Modulation Driver in 130-nm CMOS Technology for Quantum Key Distribution System
摘要： The imaging of dysregulated cell-surface receptors (or biomarkers) is a potential means of identifying the presence of cancer with high sensitivity and specificity. However, due to heterogeneities in the expression of protein biomarkers in tumors, molecular imaging technologies should ideally be capable of visualizing a multiplexed panel of cancer biomarkers. Recently, surface-enhanced Raman-scattering (SERS) nanoparticles (NPs) have attracted wide interest due to their potential for sensitive and multiplexed biomarker detection. In this review, we focus on the most recent advances in tumor imaging using SERS-coded NPs. A brief introduction of the structure and optical properties of SERS NPs is provided, followed by a detailed discussion of key imaging issues such as the administration of NPs in tissue (topical versus systemic), the optical configuration and imaging approach of Raman imaging systems, spectral demultiplexing methods for quantifying NP concentrations, and the disambiguation of specific versus nonspecific sources of contrast through ratiometric imaging of targeted and untargeted (control) NP pairs. Finally, future challenges and directions are briefly outlined.
关键词： molecular imaging,fiberoptic probes,Biomarkers,cancer detection,nanomedicine,tumors,Raman spectroscopy,biomedical optical imaging
更新于2025-09-19 17:13:59
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[IEEE 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Chicago, IL, USA (2019.6.16-2019.6.21)] 2019 IEEE 46th Photovoltaic Specialists Conference (PVSC) - Elevating Low-Quality Silicon Wafers For High-Efficiency Silicon Heterojunction Solar Cell Applications
摘要： This paper relates to a genuine wrist pulse oximeter, which is a noninvasive medical device that can measure the pulse rate and oxygen saturation level in a person’s blood. The device is novel due to its innovative design. It is a new type of re?ective oximeter, which has a concave structure for housing the optical source and sensor. The neo-re?ective sensor module of the device is designed to send the sensor data to a nearby intelligent mobile phone using wireless data transmission. The pulse oximeter has been developed and calibrated, and the calibration curve was analyzed. The innovative design of this pulse oximeter would enable the user to wear the low-cost device on one wrist continuously throughout the day, without the inconvenience of a conventional ?nger pulse oximeter.
关键词： wrist oximeter,Biomedical sensor,blood oxygen saturation,re?ective oximetry,pulse oximetry
更新于2025-09-19 17:13:59
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Self-Assembled Polysaccharide–Diphenylalanine/Au Nanospheres for Photothermal Therapy and Photoacoustic Imaging
摘要： Gold-based nanomaterials have attracted extensive interest for potential application in photothermal therapy (PTT) owing to their distinctive properties including high photothermal transduction, biocompatibility, and low cytotoxicity. Herein, assembled gold nanoparticle architecture-based photothermal conversion agents were synthesized by using polysaccharides (alginate dialdehyde, ADA) as both the cross-linker to induce self-assembly of diphenylalanine (FF) and the reducer for in situ reduction of Au3+ ions into Au nanoparticles (Au NPs). The extinction spectrum of the obtained self-assembled ADA?FF/Au nanospheres was finely modulated into a near-infrared region by controlling the growth of Au NPs inside the assemblies. The strong plasmonic coupling effect of the assembled Au NPs also leads to high photothermal conversion (η = 40%) of the ADA?FF/Au nanospheres, hence presenting good performance in PTT and photoacoustic imaging. This synthesis technique is promising to construct nanomaterials with desired functions for potential biomedical application by self-assembly of various nanocrystals in situ.
关键词： self-assembly,photoacoustic imaging,photothermal therapy,biomedical application,gold-based nanomaterials
更新于2025-09-16 10:30:52
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Light-controlled two-dimensional TiO <sub/>2</sub> plate micromotors
摘要： In this work, UV light-controlled two-dimensional (2D) TiO2 plate micromotors are demonstrated for the first time. The 2D TiO2 micromotors are produced by the well-known anodic oxidation method in combination with a cracking and separation process. When the motor is placed in H2O2 aqueous solution under UV irradiation, oxygen bubbles are generated in the holes of the TiO2 membrane. The 2D micromotor thus moves upon O2 bubbles under its own weight. In contrast to bubble-propelled micromotors, which require an addition of surfactants to chemical fuels, the 2D micromotor is capable of moving in aqueous H2O2 solution without surfactants. Moreover, speed of the 2D TiO2 micromotor can be controlled by the intensity of the UV light. Such surfactant-free micromotors and their facile fabrication hold considerable promise for diverse practical applications in the biomedical and energy fields, for example, and in new materials.
关键词： two-dimensional TiO2 plate micromotors,UV light-controlled,anodic oxidation method,energy fields,surfactant-free,biomedical applications
更新于2025-09-16 10:30:52
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[IEEE 2019 International Workshop on Electromagnetics: Applications and Student Innovation Competition (iWEM) - Qingdao, China (2019.9.18-2019.9.20)] 2019 International Workshop on Electromagnetics: Applications and Student Innovation Competition (iWEM) - A Miniaturized Coplanar Waveguide-fed Antenna for Implantable Application at ISM Band
摘要： This paper proposes a novel implantable antenna design for biomedical applications. The antenna is designed to operate at 2.45 GHz, which is a common frequency for biomedical telemetry. The proposed antenna has a small size of 10 mm × 10 mm × 1.27 mm and is printed on a Rogers RO3210 substrate. The antenna is fed by a 50 Ω coaxial probe and is designed to be implanted in the human body. The performance of the antenna is evaluated in terms of return loss, radiation pattern, and specific absorption rate (SAR). The results show that the proposed antenna has a good impedance matching and radiation performance, and the SAR values are within the safety limits.
关键词： Specific absorption rate,Implantable antenna,Rogers RO3210,Biomedical telemetry,2.45 GHz
更新于2025-09-16 10:30:52
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Revisiting the cytotoxicity of quantum dots: an in-depth overview
摘要： Recently, medical research has been shifting its focus to nanomedicine and nanotherapeutics in the pursuit of drug development research. Quantum dots (QDs) are a critical class of nanomaterials due to their unique properties, which include optical, electronic, and engineered biocompatibility in physiological environments. These properties have made QDs an attractive biomedical resource such that they have found application as both in vitro labeling and in vivo theranostic (therapy-diagnostic) agents. Considerable research has been conducted exploring the suitability of QDs in theranostic applications, but the cytotoxicity of QDs remains an obstacle. Several types of QDs have been investigated over the past decades, which may be suitable for use in biomedical applications if the barrier of cytotoxicity can be resolved. This review attempts to report and analyze the cytotoxicity of the major QDs along with relevant related aspects.
关键词： Theranostic agents,Quantum dots,Biocompatibility,Cytotoxicity,Biomedical applications
更新于2025-09-16 10:30:52
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A Further Analysis on Ti6Al4V Lattice Structures Manufactured by Selective Laser Melting
摘要： Mechanical and architectural features play an important role in designing biomedical devices. The use of materials (i.e., Ti6Al4V) with Young’s modulus higher than those of natural tissues generally cause stress shielding e?ects, bone atrophy, and implant loosening. However, porous devices may be designed to reduce the implant sti?ness and, consequently, to improve its stability by promoting tissue ingrowth. If porosity increases, mass transport properties, which are crucial for cell behavior and tissue in-growth, increase, whereas mechanical properties decrease. As reported in the literature, it is always possible to tailor mass transport and mechanical properties of additively manufactured structures by varying the architectural features, as well as pore shape and size. Even though many studies have already been made on di?erent porous structures with controlled morphology, the aim of current study was to provide only a further analysis on Ti6Al4V lattice structures manufactured by selective laser melting. Experimental and theoretical analyses also demonstrated the possibility to vary the architectural features, pore size, and geometry, without dramatically altering the mechanical performance of the structure.
关键词： selective laser melting,lattice structures,Ti6Al4V,biomedical devices,mechanical properties
更新于2025-09-12 10:27:22
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Simulation and in vivo investigation of LED-NIR Gaussian beam profile
摘要： Near infrared spectroscopy is an optical imaging technique which offers a non-invasive, portable, and low-cost method for continuously measuring the oxygenation of tissues. In particular, it can provide the brain activation through measuring the blood oxygenation and blood volume in the cortex. Understanding and then improving the spatial and depth sensitivity of near infrared spectroscopy measurements to brain tissue are essential for designing experiments as well as interpreting research findings. In this study, we investigate the effect of applying two common light beam profiles including Uniform and Gaussian on the penetration depth of an LED-based near infrared spectroscopy. In this regard, two Gaussian profiles were produced by adjusting plano-convex and bi-convex lenses and the Uniform profile was provided by applying a flat lens. Two experiments were conducted in this study. First, a simulation experiment was carried out based on scanning the intra space of a liquid phantom by using static and pulsating absorbers to compare the penetration depth of the configurations applied on the LED-based near infrared spectroscopy with that of a laser-based near infrared spectroscopy. Second, to show the feasibility of the best proposed configuration applied, an in vivo experiment of stress assessment has been performed and its results have been compared with that results obtained by laser one. The results showed that the LED-based near infrared spectroscopy equipped with bi-convex lens provides a penetration depth and hence quality measurements of near infrared spectroscopy and its extracted heart rate variability signals as well as laser-based near infrared spectroscopy especially in the application of stress assessment.
关键词： Biomedical optic,instrumentation,stress assessment,near infrared spectroscopy,optical sensors
更新于2025-09-12 10:27:22
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[IEEE 2019 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech) - St. Petersburg, Russia (2019.10.17-2019.10.18)] 2019 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech) - Optimization of Spectral Characteristics of the Controlled Color-Dynamic Surgical Light Source for Visualization of Organs and Tissues of Laboratory Animals
摘要： Modern LED light sources have many advantages for operational lighting. They make it possible to choose the optimal type of lighting for the surgeon during operations on certain organs and systems. The study was aimed at experimental selection of lighting parameters for various organs in vivo in normal and pathological conditions using a controlled color-dynamic LED lamp. The results showed that specific spectral parameters of lighting are necessary for certain types of organs and tissues; color and light balance adjusting improves the contrast visualization of individual tissues relative to each other. This work is the initial stage of creation of a special atlas of light source parameters for visualization of organs and tissues during surgical interventions with the use of controlled color-dynamic surgical light source.
关键词： contrast visualization of biological tissues,controlled semiconductor light sources,LEDs,surgical lighting,biomedical optical imaging,color dynamic parameters
更新于2025-09-12 10:27:22
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Optimization of Laser Shock Peening For Titanium
摘要： Present competitive world is looking for Components with high strength and fatigue resistance finding their applications in aerospace, turbine parts and especially bio-medical devices with high bio-compatibility. Advanced engineering techniques are required to produce parts of higher complexities and desirable surface qualities. Laser peening stood first in a row of all various surface treatments of metallic component. A Fundamental purpose of nobility of the nearby variations in residual stress that happen inside the processed region, that are sensitive to processing variables and not effectively measured tentatively. The rule of residual .stress .is important .in guaranteeing .the nobility of engineering segments and Laser. Shock. Peening (LSP) process .can be utilized to great impact to present the gainful compressive residual . stress .levels as required. It is, nonetheless, hard to utilize ordinary laser . peening .rule .frameworks to set up the perfect peening .state that . will bring about the best .execution. This .paper.. results .from .a study .to optimize the .laser .peening .parameters . for a typical . titanium.. ND- YAG laser equipment was taken for the experimental work and statistical Taguchi technique was .used .to bound .the number .of experiments .necessary .for optimization .to be feasible.
关键词： Fatigue life,Taguchi Technique,Biomedical applications,Laser peening
更新于2025-09-12 10:27:22