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- 摘要
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- 实验方案
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Optical Coherence Tomography as an Oral Cancer Screening Adjunct in a Low Resource Settings
摘要： Oral cancer is the sixth most common cancer worldwide, predominantly seen in low and middle-income countries (LMIC). Two thirds of all cases are detected at a late stage when prognosis and treatment outcomes are poor. Oral lesions are commonly detected by visual inspection, followed by invasive surgical biopsy and time-consuming histopathological analysis. Optical coherence tomography (OCT), a minimally invasive tomographic imaging technology, can be used to non-invasively identify premalignant or malignant change in the oral mucosa. In this study, a mobile OCT imaging system was designed, constructed, and tested for its performance as a point-of-care oral diagnostic device in an LMIC. 20 patients with suspicious oral lesions and 10 healthy subjects were enrolled in this pilot study. Two-dimensional (2-D) OCT images as well as clinical examination data, risk habit history, and histopathology were collected. OCT images for healthy oral mucosa, dysplasia, and malignancy were evaluated in a blinded fashion by visual scoring and computed image processing techniques. It was found that the OCT image processing algorithm performed at or exceeded the performance of visual observer scoring of OCT images.
关键词： cancer,Image classification,optical coherence tomography,biomedical optical imaging,biomedical image processing
更新于2025-09-23 15:21:21
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[IEEE 2019 IEEE 4th International Conference on Integrated Circuits and Microsystems (ICICM) - Beijing, China (2019.10.25-2019.10.27)] 2019 IEEE 4th International Conference on Integrated Circuits and Microsystems (ICICM) - A Laser Modulation Driver in 130-nm CMOS Technology for Quantum Key Distribution System
摘要： The imaging of dysregulated cell-surface receptors (or biomarkers) is a potential means of identifying the presence of cancer with high sensitivity and specificity. However, due to heterogeneities in the expression of protein biomarkers in tumors, molecular imaging technologies should ideally be capable of visualizing a multiplexed panel of cancer biomarkers. Recently, surface-enhanced Raman-scattering (SERS) nanoparticles (NPs) have attracted wide interest due to their potential for sensitive and multiplexed biomarker detection. In this review, we focus on the most recent advances in tumor imaging using SERS-coded NPs. A brief introduction of the structure and optical properties of SERS NPs is provided, followed by a detailed discussion of key imaging issues such as the administration of NPs in tissue (topical versus systemic), the optical configuration and imaging approach of Raman imaging systems, spectral demultiplexing methods for quantifying NP concentrations, and the disambiguation of specific versus nonspecific sources of contrast through ratiometric imaging of targeted and untargeted (control) NP pairs. Finally, future challenges and directions are briefly outlined.
关键词： molecular imaging,fiberoptic probes,Biomarkers,cancer detection,nanomedicine,tumors,Raman spectroscopy,biomedical optical imaging
更新于2025-09-19 17:13:59
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[IEEE 2019 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech) - St. Petersburg, Russia (2019.10.17-2019.10.18)] 2019 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech) - Optimization of Spectral Characteristics of the Controlled Color-Dynamic Surgical Light Source for Visualization of Organs and Tissues of Laboratory Animals
摘要： Modern LED light sources have many advantages for operational lighting. They make it possible to choose the optimal type of lighting for the surgeon during operations on certain organs and systems. The study was aimed at experimental selection of lighting parameters for various organs in vivo in normal and pathological conditions using a controlled color-dynamic LED lamp. The results showed that specific spectral parameters of lighting are necessary for certain types of organs and tissues; color and light balance adjusting improves the contrast visualization of individual tissues relative to each other. This work is the initial stage of creation of a special atlas of light source parameters for visualization of organs and tissues during surgical interventions with the use of controlled color-dynamic surgical light source.
关键词： contrast visualization of biological tissues,controlled semiconductor light sources,LEDs,surgical lighting,biomedical optical imaging,color dynamic parameters
更新于2025-09-12 10:27:22