- 标题
- 摘要
- 关键词
- 实验方案
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Handbook of Bioelectronics (Directly Interfacing Electronics and Biological Systems) || CMOS nanowire biosensing systems
摘要： Lowering the costs of healthcare and increasing its accessibility is a critical need of today’s society. Miniaturized electronic sensors are a possible way to both improve healthcare and lower the cost of medical diagnostics. Their small size and portability can lead to integration into personalized diagnostics tools and emergency care. In addition, faster, smaller and more efficient sensors can greatly impact chemical and biological safety.
关键词： biosensing,CMOS,nanowire,diagnostics,healthcare
更新于2025-09-04 15:30:14
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Quantifying single-cell secretion in real time using resonant hyperspectral imaging
摘要： Cell communication is primarily regulated by secreted proteins, whose inhomogeneous secretion often indicates physiological disorder. Parallel monitoring of innate protein-secretion kinetics from individual cells is thus crucial to unravel systemic malfunctions. Here, we report a label-free, high-throughput method for parallel, in vitro, and real-time analysis of specific single-cell signaling using hyperspectral photonic crystal resonant technology. Heterogeneity in physiological thrombopoietin expression from individual HepG2 liver cells in response to platelet desialylation was quantified demonstrating how mapping real-time protein secretion can provide a simple, yet powerful approach for studying complex physiological systems regulating protein production at single-cell resolution.
关键词： single-cell analysis,photonic biosensing,photonic crystal,label-free
更新于2025-09-04 15:30:14
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Highly Sensitive, Affordable, and Adaptable Refractive Index Sensing with Silicon‐Based Dielectric Metasurfaces
摘要： A sensing platform is presented that uses dielectric Huygens source metasurfaces to measure refractive index changes in a microfluidic channel with experimentally measured sensitivity of 323 nm RIU?1, a figure of merit (FOM) of 5.4, and a response of 8.2 (820%) change in transmittance per refractive index unit (T/RIU). Changes in the refractive index of liquids flown through the channel are measured by single-wavelength transmittance measurement, requiring only a simple light source and photodetector, significantly reducing device expense in comparison to state-of-the-art refractive index sensing technologies. A technoeconomic analysis predicts a device costing ≈$2400 that is capable of detecting refractive index changes of the order of 2*10?8. The metasurfaces utilized are low profile, scalable, and use materials and fabrication processes compatible with CMOS and other technologies making them suitable for device integration. The Huygens metasurface system, characterized by spectrally overlapping electric and magnetic dipole modes, offers a high degree of customizability. Interplay between the two resonances may be controlled via metasurface geometry, leading to tunability of device sensitivity and measurement range. Ultrahigh sensitivity of 350 nm RIU?1 with FOM of 219, corresponding to single-wavelength sensitivity of 360 RIU?1, is demonstrated computationally through use of antisymmetric resonances of a Huygens metasurface illuminated at small incidence angles.
关键词： metasurface,refractive index sensing,subwavelength structures,biosensing,nanophotonics
更新于2025-09-04 15:30:14