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Magnetic iron oxide nanoparticles/10-hydroxy camptothecin co-loaded nanogel for enhanced photothermal-chemo therapy
摘要： Iron oxide nanoparticle is a promising nano-biomaterial for treating iron deficiency, or as drug carriers and contrast agent as well as stimulator to elicit ROS generation. However, because of their intrinsic structure, therapeutic agents are hard to be loaded by them alone. Nanogel is a promising candidate for co-loading of iron oxide and therapeutic drug, due to its network structure and permeability. In this study, we use pre-prepared nanogel as surfactant to co-load hydrophobic magnetic nanoparticles (MNPs) and anti-cancer drug (10-hydroxy camptothecin, HCPT) to construct MNPs/HCPT-nanogel for cancer diagnosis and therapy. By in vitro and in vivo evaluation, we reveal that the obtained MNPs/HCPT-nanogel are stable in aqueous environment and can be served as drug delivery system to efficiently inhibit the tumor growth as well as MRI contrast agent for MR imaging. The introduction of MNPs elicits the generation of ROS with the presence of macrophage, which can further inhibit the growth of cancer cell. Furthermore, the introduction of extra-magnetic field can further enhance the enrichment of MNPs/HCPT-nanogel in the tumor site, which further improves the chemotherapeutic outcome. Besides, the obtained MNP/HCPT-nanogel can be used as nanocarrier for photothermal therapy for its absorption at NIR region. With the combination of PTT and chemotherapy, not only can the growth primary tumor be inhibited, but also the metastasis can be alleviated. It demonstrates that the MNP/HCPT-nanogel can be served as a promising candidate for cancer PTT/chemotherapy to inhibit tumor growth and alleviate metastasis.
关键词： Cancer diagnosis,Biomaterials,Photothermal therapy,Nanogel,Magnetic nanoparticle,10-Hydroxy camptothecin
更新于2025-09-10 09:29:36
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Fluorescence-Guided Cancer Diagnosis and Surgery by a Zero Cross-Talk Ratiometric Near-Infrared γ-Glutamytranspeptidase Fluorescent Probe
摘要： The ability to early detect cancer in an accurate and rapid fashion is of critical importance for cancer diagnosis and accurate resection in surgery. γ-Glutamyltranspeptidase (GGT) is overexpressed in several human cancers while keeps low expression in normal microenvironment, and thus recognized as an important cancer biomarker. To date, rational design of a zero cross-talk ratiometric near-infrared (NIR) GGT fluorescent probe for efficiently cancer diagnosis in various biological samples is still a big challenge. In this work, a zero cross-talk ratiometric NIR GGT fluorescent probe named Cy-GSH is developed. Cy-GSH shows highly sensitive to GGT, which is desired for cancer early diagnosis. Upon additional GGT, a large emission shift from 805 nm to 640 nm is observed, which is suitable for visualizing deeply located cancer in vivo. In addition, successful monitoring GGT activity in bloods, cells, tissues and in vivo, makes Cy-GSH possess great potentials for the clinical cancer early diagnosis. Furthermore, accurate visualizing tumors and metastases in mouse models illuminates that the probe may be a convenient tool for fluorescence-guided cancer surgery. To our knowledge, this is the first report to describe the strategy of a zero cross-talk ratiometric NIR GGT fluorescent probe for cancer early diagnosis and fluorescence-guided surgery.
关键词： fluorescent probe,γ-Glutamyltranspeptidase,GGT,cancer diagnosis,fluorescence-guided surgery
更新于2025-09-04 15:30:14