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In Nano, Volume 12, Issue 10
摘要： Vaccines have proven to be increasingly powerful in fighting and preventing cancer. For vaccines to be effective, the efficient delivery of antigens and immunomodulators to lymph nodes is critical. There, these agents aid in the maturation and activation processes for antigen presenting cells (APCs). Microneedles offer an attractive way to deliver vaccines through the skin, avoiding unnecessary pain while also accessing resident APCs in the skin. Among various types of microneedles, those that dissolve offer advantages such as ease of preparation and improved safety. However, dissolving microneedles are typically prepared using water-soluble sugars or polymers to facilitate rapid dissolution in intradermal fluid, compositions that complicate the incorporation of poorly water-soluble vaccine components.
关键词： cancer,vaccines,lymph nodes,immunomodulators,microneedles
更新于2025-09-23 15:21:01
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Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory
摘要： Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic immuno photothermal nanotherapy (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model.
关键词： gold nanostars,cancer immunology,immunotherapy,cancer vaccines,photothermal therapy,glioblastoma
更新于2025-09-12 10:27:22